Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Pathological characteristics on porcine enteritis associated with porcine circovirus type 2 in Jeju

제주지역의 돼지 써코바이러스 2형 관련 장염에 대한 병리학적 특징

  • Mun, Seong-Hwan (Jeju Self-Governing Provincial Veterinary Research Institute) ;
  • Yang, Hyoung-Seok (Jeju Self-Governing Provincial Veterinary Research Institute) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 문성환 (제주특별자치도 동물위생시험소) ;
  • 양형석 (제주특별자치도 동물위생시험소) ;
  • 김재훈 (제주대학교 수의과대학 및 수의과학연구소)
  • Received : 2020.05.21
  • Accepted : 2020.07.16
  • Published : 2020.09.30
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Abstract

From 2006 to 2009, 50 pigs suspected of enteritis associated with porcine circovirus type 2 (PCV-2) (EAPC) were collected. Gross and histopathologic examinations and immunohistochemistry (IHC) were performed on the small intestine of 50 pigs. The pigs with EAPC were concentrated in grower pigs (68%), and diarrhea (84%) was the most common clinical sign. Grossly, the walls of the small intestine were thickened, and mesenteric lymph nodes were enlarged. The histopathologic features in the small intestine with EAPC were characterized by lymphoid depletion, histiocytic infiltration, and formation of basophilic grape-like inclusion bodies and multinucleated giant cells in gut-associated lymphatic tissue (GALT) and lamina propria. According to IHC, PCV-2 antigens were more intense and distributed widely in GALT (98%) than lamina propria (82%) of the small intestine. Co-infection with other enteric pathogens was detected in 26 pigs (52%). Twenty-four pigs (48%) were confirmed to be a PCV-2 single infection. Collectively, infected PCV-2 in the small intestine may induce an immunosuppressive status of individuals and then allow secondary co-infections in the digestive system. This study shows that PCV-2 can induce diarrhea and enteric lesions in pigs without a co-infection of other enteric pathogens.

Keywords

References

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