Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Comparing the Therapeutic Effects of Aloe vera and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial

  • Panahi, Yunes (Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences) ;
  • Rastgar, Nassim (Department of Pharmaceutics, Faculty of Pharmacy, Pharmaceutical Science Branch, Islamic Azad University) ;
  • Zamani, Ali (Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences) ;
  • Sahebkar, Amirhossein (Halal Research Center of IRI, FDA)
  • Received : 2018.03.28
  • Accepted : 2020.08.28
  • Published : 2020.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Atopic dermatitis (AD) is a prevalent and chronic, pruritic inflammatory skin condition that can influence all age groups. AD is associated with a poor health-related quality of life. This randomized clinical trial was performed to compare the effectiveness of Olivederma (combination of aloe vera and virgin olive oil) or betamethasone regarding disease severity, quality of life, serum IgE and eosinophil count. Methods: Thirty-six AD patients were randomly allocated to topical Olivederma or betamethasone, and were followed for 6 weeks. Results: Total SCORAD severity scores showed significant decrease in both groups, while it was more prominent in Olivederma group (64.5% improvement in Olivederma vs. 13.5% improvement in Betamethasone, p-value < 0.001). Quality of life (DLQI questionnaire) of AD patients was significantly improved after 6 weeks treatment with Betamethasone (22.3%, p < 0.001) and Olivederma (60.7%, p-value < 0.001). Olivederma group showed a significantly lower DLQI score in comparison with Betamethasone treated patients after 6 weeks of therapy (p < 0.001). Improvements in eosinophil count and serum IgE was observed. Conclusion: In summary, this study shows that Olivederma is superior to topical Betamethasone after 6 weeks of therapy with regard to disease severity, quality of life and eosinophil count.

Keywords

References

  1. Bae JM, Choi YY, Park CO, Chung KY, Lee KH. Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2013;132(1):110-7. https://doi.org/10.1016/j.jaci.2013.02.044
  2. Kiebert G, Sorensen SV, Revicki D, Fagan SC, Doyle JJ, Cohen J, et al. Atopic dermatitis is associated with a decrement in healthrelated quality of life. Int J Dermatol. 2002;41(3):151-8. https://doi.org/10.1046/j.1365-4362.2002.01436.x
  3. Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116-32. https://doi.org/10.1016/j.jaad.2014.03.023
  4. Hoare C, Li Wan Po A, Williams H. Systematic review of treatments for atopic eczema. Health Technol Assess. 2000;4(37):1-191.
  5. Callen J, Chamlin S, Eichenfield LF, Ellis C, Girardi M, Goldfarb M, et al. A systematic review of the safety of topical therapies for atopic dermatitis. Br J Dermatol. 2007;156(2):203-21. https://doi.org/10.1111/j.1365-2133.2006.07538.x
  6. Verallo-Rowell VM, Dillague KM, Syah-Tjundawan BS. Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis. 2008;19(6):308-15. https://doi.org/10.2310/6620.2008.08052
  7. Vazquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 1996;55(1):69-75. https://doi.org/10.1016/S0378-8741(96)01476-6
  8. Williams HC, Burney PG, Hay RJ, Archer CB, Shipley MJ, Hunter JJ, et al. The U.K. working party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131(3):383-96. https://doi.org/10.1111/j.1365-2133.1994.tb08530.x
  9. Schallreuter K, Levenig C, Berger J. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186(1):23-31. https://doi.org/10.1159/000247298
  10. Atiba A, Ueno H, Uzuka Y. The effect of aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats. J Vet Med Sci. 2011;73(5):583-9. https://doi.org/10.1292/jvms.10-0438
  11. Chithra P, Sajithlal GB, Chandrakasan G. Influence of aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol. 1998;59(3):195-201. https://doi.org/10.1016/S0378-8741(97)00124-4
  12. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol. 1998;59(3):179-86. https://doi.org/10.1016/S0378-8741(97)00112-8
  13. Jafarzadeh H, Arabi M, Najafi N, Ahadi AM. Effect of aloe vera gel on TGF-${\beta}$ gene expression in incisional skin wound in BALB/c mice. J Gorgan Univ Med Sci. 2014;16(3):16-23.
  14. Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of aloe vera used for burn wound healing: a systematic review. Burns. 2007;33(6):713-8. https://doi.org/10.1016/j.burns.2006.10.384
  15. Molazem Z, Mohseni F, Younesi M, Keshavarzi S. Aloe vera gel and cesarean wound healing; a randomized controlled clinical trial. Glob J Health Sci. 2014;7(1):203-9. https://doi.org/10.5539/gjhs.v7n1p203
  16. Takzare N, Hosseini MJ, Hasanzadeh G, Mortazavi H, Takzare A, Habibi P. Influence of Aloe Vera gel on dermal wound healing process in rat. Toxicol Mech Methods. 2009;19(1):73-7. https://doi.org/10.1080/15376510802442444
  17. Takzaree N, Hassanzadeh G, Rouini MR, Keshtkar A, Manayi A, Haajiakhondi A. Histological study of wound repair with topical aloe vera gel in rat. Tehran Univ Med J. 2015;73(9):660-7.
  18. Visuthikosol V, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai. 1995;78(8):403-9.
  19. Yadav KCH, Kumar JR, Basha SI, Deshmukh GR, Gujjula R, Santhamma B. Wound healing activity of topical application of aloe vera gel in experimental animal models. Int J Pharm Bio Sci. 2012;3(2):63-72.
  20. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebocontrolled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19(3):326-31. https://doi.org/10.1111/j.1468-3083.2004.01186.x
  21. Viola P, Viola M. Virgin olive oil as a fundamental nutritional component and skin protector. Clin Dermatol. 2009;27(2):159-65. https://doi.org/10.1016/j.clindermatol.2008.01.008
  22. Clendenning WE, Clack WE, Ogawa M, Ishizaka K. Serum IgE studies in atopic dermatitis. J Invest Dermatol. 1973;61(4):233-6. https://doi.org/10.1111/1523-1747.ep12676481
  23. Johnson EE, Irons JS, Patterson R, Roberts M. Serum IgE concentration in atopic dermatitis. Relationship to severity of disease and presence of atopic respiratory disease. J Allergy Clin Immunol. 1974;54(2):94-9. https://doi.org/10.1016/0091-6749(74)90037-2
  24. Uehara M, Izukura R, Sawai T. Blood eosinophilia in atopic dermatitis. Clin Exp Dermatol. 1990;15(4):264-6. https://doi.org/10.1111/j.1365-2230.1990.tb02086.x