Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Short- and long-term outcomes of very low birth weight infants in Korea: Korean Neonatal Network update in 2019

  • Lee, Jang Hoon (Department of Pediatrics, Ajou University School of Medicine) ;
  • Youn, YoungAh (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Chang, Yun Sil (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2019.07.15
  • Accepted : 2019.12.11
  • Published : 2020.08.15
Download PDF
⟨ Previous Next ⟩

Abstract

Korea currently has the world's lowest birth rate but a rapidly inreasing number of preterm infants. The Korean Neonatal Network (KNN), launched by the Korean Society of Neonatology under the support of Korea Centers for Disease Control, has collected population-based data for very low birth weight infants (VLBWIs) born in Korea since 2013. In terms of the short-term outcomes of VLBWIs born from 2013 to 2016 registered in the KNN, the survival rate of all VLBWIs was 86%. Respiratory distress syndrome and bronchopulmonary dysplasia were observed in 78% and 30% of all VLBWIs, respectively. Necrotizing enterocolitis occurred in 7%, while 8% of the VLBWIs needed therapy for retinopathy of prematurity in the neonatal intensive care unit (NICU). Sepsis occurred in 21% during their NICU stay. Intraventricular hemorrhage (grade ≥III) was diagnosed in 10%. In terms of the long-term outcomes for VLBWIs born from 2013 to 2014 registered in the KNN, the post-discharge mortality rate was approximately 1.2%-1.5%, mainly owing to their underlying illness. Nearly half of the VLBWIs were readmitted to the hospital at least once in their first 1-2 years of life, mostly as a result of respiratory diseases. The overall prevalence of cerebral palsy was 6.2%-6.6% in Korea. Bilateral blindness was reported in 0.2%-0.3% of VLBWIs, while bilateral hearing loss was found in 0.8%-1.9%. Since its establishment, the KNN has published annual reports and papers that facilitate the improvement of VLBWI outcome and the formulation of essential healthcare policies in Korea.

Keywords

References

  1. Statistic Korea. Monthly, quarterly, and annual population trends (birth, death, marriage, divorce statistics) [Internet]. Daejeon (Korea): Statistic Korea; 2019 [cited 2019 Jun 7]. Available from: http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1B8000G&vw_cd=MT_ZTITLE&list_d=A2&seqNo=&lang_mode=ko&language=kor&obj_var_id=&itm_id=& conn_path=MT_ZTITLE.
  2. Moon JY, Hahn WH, Shim KS, Chang JY, Bae CW. Changes of maternal age distribution in live births and incidence of low birth weight infants in advanced maternal age group in Korea. Korean J Perinatol 2011;22:30-6.
  3. Birth according to birth weight http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1B80A03&vw_cd=MT_ZTITLE&list_id=A21&seqNo=&lang_mode=ko&language=kor&obj_var_id=&itm_id=&conn_path=MT_ZTITLE Updated 2018-08-22, Accessed June 7, 2019
  4. Chung JH, Phibbs CS, Boscardin WJ, Kominski GF, Ortega AN, Needleman J. The effect of neonatal intensive care level and hospital volume on mortality of very low birth weight infants. Med Care 2010;48:635-44. https://doi.org/10.1097/MLR.0b013e3181dbe887
  5. Chang YS, Park HY, Park WS. The Korean Neonatal Network: an overview. J Korean Med Sci 2015;30(Suppl 1):S3-11. https://doi.org/10.3346/jkms.2015.30.S1.S3
  6. The Executive Committee of Korean Neonatal Network. 2017 Korean Neonatal Network annual report. Cheongju (Korea): Korean Centers for Disease Control and Prevention, 2018.
  7. Korean Neonatal Network. Status of registration in Korean Neonatal Network [Internet]. Seoul (Korea): Korean Neonatal Network; 2019 [cited 2019 Jun 7]. Available from: http://www.knn.or.kr/.
  8. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015;385:430-40. https://doi.org/10.1016/S0140-6736(14)61698-6
  9. Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008;371:261-9. https://doi.org/10.1016/S0140-6736(08)60136-1
  10. Lee JH, Noh OK, Chang YS. Neonatal outcomes of very low birth weight infants in Korean Neonatal Network from 2013 to 2016. J Korean Med Sci 2019;34:e40. https://doi.org/10.3346/jkms.2019.34.e40
  11. Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. Lancet 2006;367:1421-31. https://doi.org/10.1016/S0140-6736(06)68615-7
  12. Majnemer A, Riley P, Shevell M, Birnbaum R, Greenstone H, Coates AL. Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors. Dev Med Child Neurol 2000;42:53-60. https://doi.org/10.1017/S001216220000013X
  13. Van Marter LJ. Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med 2009;14:358-66. https://doi.org/10.1016/j.siny.2009.08.007
  14. Jo HS, Cho KH, Cho SI, Song ES, Kim BI. Recent changes in the incidence of bronchopulmonary dysplasia among very-low-birth-weight infants in Korea. J Korean Med Sci 2015;30(Suppl 1):S81-7. https://doi.org/10.3346/jkms.2015.30.S1.S81
  15. Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, et al. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: results of the EPIPAGE-2 cohort study. JAMA Pediatr 2015;169:230-8. https://doi.org/10.1001/jamapediatrics.2014.3351
  16. Isayama T, Lee SK, Mori R, Kusuda S, Fujimura M, Ye XY, et al. Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan. Pediatrics 2012;130:e957-65. https://doi.org/10.1542/peds.2012-0336
  17. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126:443-56. https://doi.org/10.1542/peds.2009-2959
  18. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA 2015;314:1039-51. https://doi.org/10.1001/jama.2015.10244
  19. The Executive Committee of Korean Neonatal Network. 2013 Korean Neonatal Network annual report. Cheongju (Korea): Korean Centers for Disease Control and Prevention, 2014.
  20. The Executive Committee of Korean Neonatal Network. 2014 Korean Neonatal Network annual report. Cheongju: Korean Centers for Disease Control and Prevention, 2015.
  21. Youn Y, Lee SM, Hwang JH, Cho SJ, Kim EK, Kim EA. National registry data from Korean Neonatal Network: two-year outcomes of Korean very low birth weight infants born in 2013-2014. J Korean Med Sci 2018;33:e309. https://doi.org/10.3346/jkms.2018.33.e309
  22. Saigal S, den Ouden L, Wolke D, Hoult L, Paneth N, Streiner DL, et al. School-age outcomes in children who were extremely low birth weight from four international population-based cohorts. Pediatrics 2003;112:943-50. https://doi.org/10.1542/peds.112.4.943
  23. Anderson P, Doyle LW; Victorian Infant Collaborative Study Group. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA 2003;289:3264-72. https://doi.org/10.1001/jama.289.24.3264
  24. Breslau N, Chilcoat HD. Psychiatric sequelae of low birth weight at 11 years of age. Biol Psychiatry 2000;47:1005-11. https://doi.org/10.1016/S0006-3223(99)00312-1

Cited by

  1. Predictive Model for Motor Developmental Delay in Preterm Infants by Using Recurrent Neural Network vol.31, pp.4, 2020, https://doi.org/10.14734/pn.2020.31.4.209
  2. Physiologic Changes during Sponge Bathing in Premature Infants vol.18, pp.5, 2021, https://doi.org/10.3390/ijerph18052467
  3. Current Status of Traditional Korean Medicine Services in Public Sector: A Study for Integrating Traditional Korean Medicine into Community Care System vol.9, pp.5, 2020, https://doi.org/10.3390/healthcare9050493
  4. Retinopathy of Prematurity and Hearing Impairment in Infants Born with Very-Low-Birth-Weight: Analysis of a Korean Neonatal Network Database vol.10, pp.20, 2020, https://doi.org/10.3390/jcm10204781
  5. Nationwide incidence and treatment pattern of retinopathy of prematurity in South Korea using the 2007–2018 national health insurance claims data vol.11, pp.1, 2020, https://doi.org/10.1038/s41598-021-80989-z