Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Influence of subclinical hypothyroidism on metabolic parameters in obese children and adolescents

  • Kara, Ozlem (Department of Pediatric Endocrinology, Bursa Yuksek Ihtisas Training and Research Hospital)
  • 투고 : 2019.12.10
  • 심사 : 2020.01.30
  • 발행 : 2020.03.15
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초록

Background: Subclinical hypothyroidism (SH) is a common condition in obese children. However, its effect on glucose and lipid metabolism in obese children remains controversial. Purpose: The present study aimed to investigate the association between SH and metabolic parameters. Methods: A total of 215 obese children and adolescents aged 6-18 years were included in this retrospective cross-sectional study. The patients' anthropometric measurements such as thyrotropin (TSH), free thyroxine (fT4), fasting plasma glucose, and insulin levels, as well as homeostasis model assessment for insulin resistance (HOMA-IR) index, and lipid profiles were evaluated. The patients were allocated to the SH group (fT4 normal, TSH 5-10 mIU/L) (n=77) or the control group (fT4 normal, TSH<5 mIU/L) (n=138). The glucose and lipid metabolisms of the 2 groups were compared. Results: SH was identified in 77 of 215 patients (36%). Mean body mass index was similar in both groups. The mean serum insulin, HOMA-IR, and triglyceride (TG) levels were higher and the mean high-density lipoprotein cholesterol level was lower in the SH group than in the control group (P=0.007, P=0.004, P=0.01, and P=0.02, respectively). A positive correlation was observed between TSH level and insulin level, HOMA-IR, and TG level. Conclusion: SH was identified in some of the obese children and adolescents. A clear association was observed between SH, insulin resistance, and dyslipidemia in obese children.

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참고문헌

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피인용 문헌

  1. Oxidative DNA damage and subclinical hypothyroidism in children with obesity vol.69, 2020, https://doi.org/10.1186/s43054-021-00063-1