Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

  • Suh, Junghwan (Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine) ;
  • Choi, Han Saem (Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine) ;
  • Kwon, Ahreum (Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine) ;
  • Chae, Hyun Wook (Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine) ;
  • Kim, Ho-Seong (Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine)
  • Received : 2019.05.03
  • Accepted : 2019.12.01
  • Published : 2020.04.15
Download PDF
⟨ Previous Next ⟩

Abstract

Background: The incidence of precocious puberty has increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals including agricultural pesticides has been a subject of global study, but human data are lacking. Purpose: We investigated the relationship between agricultural pesticides and the development of precocious puberty. Methods: We enrolled 60 female subjects at Severance Children's Hospital from December 2015 to January 2017. Of them, 30 were diagnosed with precocious puberty, while the other 30 prepubertal girls were enrolled as normal controls. We investigated their clinical characteristics and analyzed the urinary levels of 320 different agricultural pesticides. Results: Agricultural pesticide was detected in one of 30 patients with precocious puberty (3.3%) versus 2 of 30 girls in the normal control group (3.3% vs. 6.7%, P=0.554). Dinotefuran, a neonicotinoid-class insecticide, was detected in the samples of all 3 positive subjects. Conclusion: Our results showed no relationship between agricultural pesticides and the development of precocious puberty. Larger sample sizes and robustly controlled variables are necessary to further investigate this topic.

Keywords

References

  1. Bergman A, Heindel J, Jobling S, Kidd K, Zoeller RTJTL. State-of-thescience of endocrine disrupting chemicals, 2012 2012:S3.
  2. Durmaz E, Asci A, Erkekoglu P, Akcurin S, Gumusel BK, Bircan I. Urinary bisphenol a levels in girls with idiopathic central precocious puberty. J Clin Res Pediatr Endocrinol 2014;6:16-21. https://doi.org/10.4274/Jcrpe.1220
  3. Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, et al. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect 2010;118:1039-46. https://doi.org/10.1289/ehp.0901690
  4. Lee SH, Kang SM, Choi MH, Lee J, Park MJ, Kim SH, et al. Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A. Reprod Toxicol 2014;44:1-6. https://doi.org/10.1016/j.reprotox.2013.03.008
  5. Chen CY, Chou YY, Wu YM, Lin CC, Lin SJ, Lee CC. Phthalates may promote female puberty by increasing kisspeptin activity. Hum Reprod 2013;28:2765-73. https://doi.org/10.1093/humrep/det325
  6. Wolff MS, Teitelbaum SL, McGovern K, Windham GC, Pinney SM, Galvez M, et al. Phthalate exposure and pubertal development in a longitudinal study of US girls. Hum Reprod 2014;29:1558-66. https://doi.org/10.1093/humrep/deu081
  7. Mouritsen A, Frederiksen H, Sorensen K, Aksglaede L, Hagen C, Skakkebaek NE, et al. Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period: associations with adrenal androgen levels and puberty. J Clin Endocrinol Metab 2013;98:3755-64. https://doi.org/10.1210/jc.2013-1284
  8. Ozen S, Goksen D, Darcan S. Agricultural pesticides and precocious puberty. Vitam Horm 2014;94:27-40. https://doi.org/10.1016/B978-0-12-800095-3.00002-X
  9. Nebesio TD, Pescovitz OH. The role of endocrine disruptors in pubertal development. In: Pescovitz OH, Walvoord EC, editors. When puberty is precocious: scientific and clinical aspects. Totowa (NJ): Humana Press Inc., 2007:425-42.
  10. Buck Louis GM, Gray LE Jr., Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, et al. Environmental factors and puberty timing: expert panel research needs. Pediatrics 2008;121 Suppl 3:S192-207. https://doi.org/10.1542/peds.1813E
  11. Jorgensen M, Vendelbo B, Skakkebaek NE, Leffers H. Assaying estrogenicity by quantitating the expression levels of endogenous estrogenregulated genes. Environ Health Perspect 2000;108:403-12. https://doi.org/10.1289/ehp.00108403
  12. Vinggaard AM, Nellemann C, Dalgaard M, Jorgensen EB, Andersen HR. Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz. Toxicol Sci 2002;69:344-53. https://doi.org/10.1093/toxsci/69.2.344
  13. Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, et al. Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. Environ Int 2014;73:135-42. https://doi.org/10.1016/j.envint.2014.06.020
  14. You M, Kang S, Park E, Lee M, Lee Y. Health authorities' and news media's responses to the 2017 pesticide detected eggs: evaluation and suggestions for better risk communication. Korean J Public Health 2017;54:21-33. https://doi.org/10.17262/KJPH.2017.12.54.2.21
  15. Kim JH, Yun S, Hwang SS, Shim JO, Chae HW, Lee YJ, et al. The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects. Korean J Pediatr 2018;61:135-49. https://doi.org/10.3345/kjp.2018.61.5.135
  16. Westland JL, Dorman FL. QuEChERS extraction of benzodiazepines in biological matrices. J Pharm Anal 2013;3:509-17. https://doi.org/10.1016/j.jpha.2013.04.004
  17. Lucini L, Molinari GP. Performance and matrix effect observed in QuEChERS extraction and tandem mass spectrometry analyses of pesticide residues in different target crops. J Chromatogr Sci 2011;49:709-14. https://doi.org/10.1093/chrsci/49.9.709
  18. Bang DY, Byeon SK, Moon MH. Rapid and simple extraction of lipids from blood plasma and urine for liquid chromatography-tandem mass spectrometry. J Chromatogr A 2014;1331:19-26. https://doi.org/10.1016/j.chroma.2014.01.024
  19. Rasier G, Toppari J, Parent AS, Bourguignon JP. Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data. Mol Cell Endocrinol 2006;254-255:187-201. https://doi.org/10.1016/j.mce.2006.04.002
  20. Ozen S, Darcan S, Bayindir P, Karasulu E, Simsek DG, Gurler T. Effects of pesticides used in agriculture on the development of precocious puberty. Environ Monit Assess 2012;184:4223-32. https://doi.org/10.1007/s10661-011-2257-6
  21. Deng F, Tao FB, Liu DY, Xu YY, Hao JH, Sun Y, et al. Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty. Eur J Endocrinol 2012;166:803-9. https://doi.org/10.1530/EJE-11-0876
  22. Wolff MS, Britton JA, Boguski L, Hochman S, Maloney N, Serra N, et al. Environmental exposures and puberty in inner-city girls. Environ Res 2008;107:393-400. https://doi.org/10.1016/j.envres.2008.03.006
  23. Bapayeva G, Issayeva R, Zhumadilova A, Nurkasimova R, Kulbayeva S, Tleuzhan R. Organochlorine pesticides and female puberty in South Kazakhstan. Reprod Toxicol 2016;65:67-75. https://doi.org/10.1016/j.reprotox.2016.06.017
  24. Van der Sluijs JP, Simon-Delso N, Goulson D, Maxim L, Bonmatin JM, Belzunces LP. Neonicotinoids, bee disorders and the sustainability of pollinator services. Curr Opin Environ Sustain 2013;5:293-305. https://doi.org/10.1016/j.cosust.2013.05.007
  25. Han W, Tian Y, Shen X. Human exposure to neonicotinoid insecticides and the evaluation of their potential toxicity: an overview. Chemosphere 2018;192:59-65. https://doi.org/10.1016/j.chemosphere.2017.10.149
  26. Kapoor U, Srivastava MK, Srivastava LP. Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats. Food Chem Toxicol 2011;49:3086-9. https://doi.org/10.1016/j.fct.2011.09.009
  27. Bal R, Naziroglu M, Turk G, Yilmaz O, Kuloglu T, Etem E, et al. Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats. Cell Biochem Funct 2012;30:492-9. https://doi.org/10.1002/cbf.2826
  28. Osaka A, Ueyama J, Kondo T, Nomura H, Sugiura Y, Saito I, et al. Exposure characterization of three major insecticide lines in urine of young children in Japan-neonicotinoids, organophosphates, and pyrethroids. Environ Res 2016;147:89-96. https://doi.org/10.1016/j.envres.2016.01.028
  29. Kavvalakis MP, Tzatzarakis MN, Theodoropoulou EP, Barbounis EG, Tsakalof AK, Tsatsakis AM. Development and application of LC- APCI-MS method for biomonitoring of animal and human exposure to imidacloprid. Chemosphere 2013;93:2612-20. https://doi.org/10.1016/j.chemosphere.2013.09.087

Cited by

  1. Diagnosis and Treatment of Central Precocious Puberty vol.44, pp.4, 2021, https://doi.org/10.12771/emj.2021.44.4.117