Review of Clinical Studies of Oral Herbal Medicine Treatment for Pediatric Chickenpox using CNKI Database - Focused on Chinese Randomized Controlled Trials after 2000s -

CNKI로 검색한 소아 수두의 한약 내복 치료에 대한 임상연구 동향 - 2000년대 이후 RCT 연구를 중심으로-

  • Choi, Jung Yoon (Department of Pediatrics, College of Korean Medicine, Dongguk University) ;
  • Kim, Jang Hyun (Department of Pediatrics, College of Korean Medicine, Dongguk University) ;
  • Min, Sang Yeon (Department of Pediatrics, College of Korean Medicine, Dongguk University)
  • 최정윤 (동국대학교 한의과대학 소아과교실) ;
  • 김장현 (동국대학교 한의과대학 소아과교실) ;
  • 민상연 (동국대학교 한의과대학 소아과교실)
  • Received : 2020.07.16
  • Accepted : 2020.08.24
  • Published : 2020.08.31


Objectives The purpose of this study is to analyze Chinese randomized controlled trials (RCTs), and to evaluate the effectiveness and safety of the oral herbal medicine treatment for pediatric chickenpox. Methods We searched RCTs after 2000s from the China National Knowledge Infrastructure (CNKI). Afterwards, the year of publication, demographic information, duration of chickenpox, intervention, treatment duration, outcome measure, results and adverse events were investigated and analyzed for this study. Results 21 RCTs out of 219 studies were collected and analyzed. Although each composition of the herbal medicine was different, they have common ingredients such as 清熱解毒, 散結消腫, 疏散風熱, 涼血解毒, 解表散風 in order to make efficacy of 清熱解毒, 散結消腫, 疏散風熱, 涼血解毒, 解表散風. The oral herbal medicine showed better efficacy and safety to improve clinical symptoms such as total efficacy, cure rate, antipyretic time, antipruritic time, scab time, anti-rash time, hospitalization period and herpes recovery time compared to the western medicine treatment. Conclusions These results show that the oral herbal medicine treatment on chickenpox in children may be more effective in reducing of clinical symptoms compared to the western medicine treatment.



  1. Centers for Disease Control and Prevention. Prevention of varicella: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR Recomm Rep. 1996;45(11):1-36.
  2. Kim JK, Lee HJ, Kim DH, Yoon MS. Original Artie: Comparison of Tzanck test and polymerase chain reaction in the diagnosis of herpes simplex virus and varicella zoster virus infections. Korean J Dermatol. 2011;49(5):422-7.
  3. Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, Martino MD, Ueno M, Brown WD, Terborg C, Gilden DH. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70(11):853-60.
  4. OH SH. Update in varicella vaccination. Korean J Pediatr. 2006;49(3):229-34
  5. Finger R, Hughes JP, Meade BJ, Pelletier AR, Palmer CT. Age-specific incidence of chickenpox. Public Health Rep. 1994;109(6):750.
  6. Kim SH, Kim JH, Oh JH , Hur JK, Kang JH, Koh DK. Post-exposure prophylaxis of varicella in family contact by oral acyclovir. Pediatr Infect Vaccine. 2002;9(1):61-6.
  7. Jung EK. Guidelines for managing infectious diseases for immunizations 2018. Cheongju: Center for Disease Control. 2018:89-95.
  8. Song XY. Efficacy of ambroxol hydrochloride in the treatment of neonatal infectious pneumonia. Chin Med Guide. 2013;3(11):659-60.
  9. Feder HM Jr., Goyal RK, Krause PJ. Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis : case report. Clin Infect Dis. 1995;20(6):1557-9.
  10. Kimberlin D, Powell D, Gruber W, Diaz P, Arvin A, Kumar M, Jacobs R, Dyke RD, Burchett S, Soong SJ, Lakeman A, Whitley R. Administration of oral acyclovir suppressive therapy after neonatal herpes simplex virus disease limited to the skin, eyes and mouth : results of a phase I/II trial. Pediatr Infect Dis J. 1996;15(3):247-54.
  11. Korean Institute of Oriental Medicine. Chickenpox [Internet]. patent office; 2007. Available from:
  12. Go NG, Choi HM, Lee YH, Jung JH, Ha JH. A clinical report on chicken pox scars treatment with Sae-ssack Therapy. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(2):146-54.
  13. Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Suh HS, Shin CM. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. 1st ed. Seoul: National Evidence-based Healthcare Collaborating Agency. 2011:65-92.
  14. Yu T. Clinical observation of 88 cases of varicella in newborns. Jilin Med. 2014; 35(31):7021-22.
  15. Tian LX, Wang JY. Observation on the curative effect of 50 cases of pediatric varicella treated with Qudou decoction by internal and external wash. J Hunan Normal Univ. 2008;5(2):62-3.
  16. Lee LQ, Wang JY, Chen HY. Observation of the curative effect of Tanshinone on children with chicken pox. Capital Med. 2005;12(16):42-3.
  17. Tian FX, Ren MC. Treatment of 64 cases of varicella in children with acne pimples combined with western medicine. Chin Community Doc. 2007;4(4):64.
  18. Zhao P, Chen YP. Lamei Jiedu decoction in the treatment of 62 cases of varicella in children with severe heat syndrome. Jiangsu J Tradit Chin Med. 2003;24(3):27-8.
  19. Tian ZX, Yi WF. Clinical observation on pediatric chickenpox treated by pediatric Soy Chingqingre granules and acyclovir. Chin Foreign Med Res. 2015;13(18):125-7.
  20. Zhang JP. Analysis of clinical efficacy and safety of acyclovir combined with Qingjietoubiao decoction in treating children with chickenpox. J Clin Ration Drug Use. 2014;7(12):135-6.
  21. Wang LY. The clinical efficacy of valacyclovir hydrochloride granules combined with Shuanghuanglian oral liquid in treating 86 cases of chickenpox in children. Chin J Clin New Med. 2018;11(3):276-9.
  22. Wang JY. The method and curative effect of treating and curing chickenpox with WujianHuichun Pills. Chin J Healthcare Med. 2015;17(3):233.
  23. Zhu J, Yang QP, Yu DH, Wang DY. Clinical observation on treatment of 43 cases of chickenpox with Yinqiao Ganlu Decoction. Pediatr Tradit Chin Med. 2009;5(3):31-3.
  24. Lin DW, Zhou L. Clinical observation on the treatment of varicella in children with addition and subtraction of Yinqiao powder. New J Tradit Chin Med. 2015;47(4):183-4.
  25. Zhao R. Clinical observation of YinqiaoJiedu decoction in treating pediatric varicella. J Pediatr Pharm. 2007;13(6):46-7.
  26. Luo XX. Efficacy and adverse reaction analysis of YinqiaoJiedu decoction on children with chickenpox. Everyone Health, 2020;27(4):98.
  27. Ren YM, Yao ZF. Study on the curative effect and side effects of YinqiaoJiedu decoction on children with chickenpox. Chin Med Mater. 2016;39(4):908-10.
  28. Luo Q. Observation of curative effect of YinhuaJiedu oral liquid on chickenpox. Clin Res Chin Med. 2013;5(18):74-6.
  29. Zhao HL, Liu JL. Self-made QingreJieduShubiao decoction for the treatment of 36 cases of children with chickenpox. Mod J Integr Tradit Chin West Med. 2006;15(16):2253
  30. Wu LY, Jiang SW, Wang YQ. Observation on the therapeutic effect of integrated traditional Chinese and western medicine on chickenpox. J Pract Tradit Chin Med. 2019;35(1):73-4.
  31. Shi CL, Zhu GJ. Clinical observation on 26 cases of chickenpox treated with integrated Chinese and western medicine. Herald Tradit Chin Med. 2013;19(8):29-31.
  32. Yuan SP, Dai JQ. Observation of curative effect of 30 cases of chickenpox treated by integrated traditional Chinese and western medicine. Pediatr Tradit Chin Med. 2007;3(6):25.
  33. Lin GS, Lin GY, Cai JW, Xie YX. Observation on the curative effect of Qingpo decoction on 45 cases of infantile chickenpox. Mod Chin Doc. 2009;47(34):134-135+143.
  34. Xie ZM. Kanggan granules for treating 40 cases of varicella in children. West Chin J Pharm. 2008;23(4):504.
  35. State Administration of Traditional Chinese Medicine of the People's Republic of China. Criteria of diagnosis and therapeutic effect of diseases and syndromes in traditional Chinese medicine. Nanjing: Nanjing University Press. 1994:83.
  36. Wang SC, He LL, Sun LP. Guidelines for clinical diagnosis and treatment of pediatrics in traditional Chinese medicine on chickenpox (revision). J Pediatr Tradit Chin Med. 2016;12(1):1-6.
  37. Hu YM. Zhu Futang Practical Pediatrics. 7th ed. Beijing: People's Medical Publishing House, 2002:746-9
  38. Cheng CF, He YH. Practical handbook of disease diagnosis and treatment. Hunan Science and Technology Press. 2006:539-40.
  39. Davies HD, McGeer A, Schwartz B, Green K, Cann D, Simor AE, Low DE. Invasive group A streptococcal infections in Ontario. N Engl J Med. 1996;335(8):547-54.
  40. Choi EH. Varicella vaccine. Hanyang Med Rev. 2008;28(3):30-6.
  41. AH Ross, E Lenchner, G Reitman. Modification of chickenpox in family contacts by administration of gamma globulin. N Engl J Med. 1962;267(8):369-76.
  42. Kim KB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yu SA, Lee SY, Lee JY, Chang GT, Jeong MJ, Chai JW, Cheon JH, Han YJ, Han JK. Hanbangsoacheongsonyeonuihak (sang). Seoul: Eui Sung Dang Publishing Co. 2015:30-33, 264-260.
  43. Alvarez D, Dieterich DT, Brau N, Moorehead L, Ball L, Sulkowski MS. Zidovudine use but not weight-based ribavirin dosing impacts anaemia during HCV treatment in HIV-infected persons. J Viral Hepat. 2006;13(10):683-9.
  44. Bani-Sadr F, Carrat F, Pol S, Hor R, Rosenthal E, Goujard C, Morand P, Lunel-Fabiani F, Salmon-Ceron D, Piroth L, Pialoux G, Bentata M, Cacoub P, Perronne C. Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy. J Acquir Immune Defic Syndr. 2005;40(1):47-52.
  45. Zuo WL, Wang P. Comparison of four inspection methods for fallopian tube patency. Chin J Obstet Gyneco. 1996;31(1):29-31.
  46. Wang JH. Chinese medicine treatment of chickenpox. Tianjin Pharm. 2006;18(4):74-5.
  47. Gao XM. Traditional Chinese medicine. Beijing: China Press of Traditional Chinese Medicine. 2006:110-32.