Pediatric Infection and Vaccine

  • 제27권2호
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  • Pages.140-146
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  • 2020
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  • 2384-1079(pISSN)
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  • 2384-1087(eISSN)
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)
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인도에서 귀국한 가족에서 발생한 심한 고혈당 동반 소아 뎅기열 1례

A Pediatric Case of Dengue Fever with Extreme Hyperglycemia Developed in a Family Who Returned from India

  • 김준영 (한림대학교 의과대학 한림대학교성심병원 소아청소년과) ;
  • 김한울 (한림대학교 의과대학 한림대학교성심병원 소아청소년과)
  • Kim, Joon Young (Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Han Wool (Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • 투고 : 2019.08.19
  • 심사 : 2019.11.01
  • 발행 : 2020.08.25
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초록

뎅기열은 풍토성을 가지며 주로 열대 및 아열대지역에서 많이 발생하는 질환이고 우리나라는 발병 지역은 아니다. 발열, 발진, 두통 등의 비특이적 증상을 보이는 해외에서 돌아온 여행자를 만나는 경우 해외유입감염병을 의심해야 한다. 지속되는 구토, 복통, 출혈 경향, 간효소수치 상승, 단백뇨 등은 뎅기열에서 심한 뎅기열로의 진행의 위험인자로 알려져 있다. 심각한 고혈당은 다양한 급성 질환에서 나쁜 예후와 관련이 있고 당뇨병 등 고혈당으로 증상이 나타날 수 있는 기저질환이 동반된 경우는 심각한 뎅기열로의 진행과도 관련이 있다고 알려져 있다. 저자들은 인도에서 귀국한 청소년에서 발생한 심한 고혈당을 동반한 뎅기열을 경험하였다. 이와 함께 한국에서 보고된 소아 뎅기열 증례들을 고찰하여 보고하는 바이다.

Dengue fever (DF) is endemic throughout tropical and subtropical regions; however, it is not endemic in Korea. Imported infectious diseases should be suspected when encountering returned travelers with non-specific symptoms such as fever, rash, and headache. Persistent vomiting, abdominal pain, hemorrhagic tendency, hepatic enzyme abnormalities, and proteinuria are risk factors for the development of severe DF in a patient with DF. Severe hyperglycemia is also known to be related to poor prognosis in acute illness, and with certain underlying diseases that present with hyperglycemia, such as diabetes, it is related to the progression of severe DF. We report a DF case with severe hyperglycemia in an adolescent returning from India. Pediatric DF cases reported in Korea were also reviewed.

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참고문헌

  1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature 2013;496:504-7. https://doi.org/10.1038/nature12060
  2. Country Office for India, World Health Organization. National guidelines for clinical management of dengue fever [Internet]. New Delhi: WHO Country Office for India; 2015 [cited 2016 Jun 14]. Available from: https://apps.who.int/iris/handle/10665/208893.
  3. Korea Centers for Disease Control and Prevention. Infectious diseases web-statistics system [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; 2019 [cited 2019 Aug 14]. Available from: http://www.cdc.go.kr/npt/.
  4. Choi SH, Kim YJ, Shin JH, Yoo KH, Sung KW, Koo HH. International travel of Korean children and dengue fever: a single institutional analysis. Korean J Pediatr 2010;53:701-4. https://doi.org/10.3345/kjp.2010.53.6.107
  5. Choi HH, Park JA, Kim JS, Hur YJ, Song MS, Hwang TG, et al. A case of an imported dengue hemorrhagic fever with spontaneous bleeding: case report and review of the literature. Korean J Pediatr Infect Dis 2011;18:207-11. https://doi.org/10.14776/kjpid.2011.18.2.207
  6. Oh MA, Shim JW, Kim DS, Jung HL, Park MS, Shim JY. Two pediatric cases of dengue fever imported from Philippines. Korean J Pediatr Infect Dis 2013;20:98-104. https://doi.org/10.14776/kjpid.2013.20.2.98
  7. Lee SM, Lee HY, Hwang JH, Kim DS, Ahn JG. A pediatric case of dengue fever due to dengue virus-1 with severe thrombocytopenia. Korean J Fam Pract 2018;8:468-72. https://doi.org/10.21215/kjfp.2018.8.3.468
  8. Chang JY, Chung UK, Yoon SH, Kim KH, Choi HJ. Two cases of dengue fever due to dengue virus-1 developed in a family. Ewha Med J 2013;36:S1-4. https://doi.org/10.12771/emj.2013.36.S.S1
  9. Zhang H, Zhou YP, Peng HJ, Zhang XH, Zhou FY, Liu ZH, et al. Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis. Biomed Res Int 2014;2014:359308. https://doi.org/10.1155/2014/359308
  10. Lee IK, Hsieh CJ, Lee CT, Liu JW. Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity. J Microbiol Immunol Infect 2020;53:69-78. https://doi.org/10.1016/j.jmii.2017.12.005
  11. Weiss SL, Alexander J, Agus MS. Extreme stress hyperglycemia during acute illness in a pediatric emergency department. Pediatr Emerg Care 2010;26:626-32. https://doi.org/10.1097/PEC.0b013e3181ef0488
  12. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003;78:1471-8. https://doi.org/10.4065/78.12.1471
  13. Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni V. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004;5:329-36. https://doi.org/10.1097/01.pcc.0000128607.68261.7c
  14. Wintergerst KA, Buckingham B, Gandrud L, Wong BJ, Kache S, Wilson DM. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006;118:173-9. https://doi.org/10.1542/peds.2005-1819
  15. Dalugama C, Gawarammana IB. Dengue hemorrhagic fever complicated with transient diabetic ketoacidosis: a case report. J Med Case Rep 2017;11:302. https://doi.org/10.1186/s13256-017-1476-z
  16. Bravo L, Roque VG, Brett J, Dizon R, L'Azou M. Epidemiology of dengue disease in the Philippines (2000-2011): a systematic literature review. PLoS Negl Trop Dis 2014;8:e3027. https://doi.org/10.1371/journal.pntd.0003027
  17. Yung CF, Lee KS, Thein TL, Tan LK, Gan VC, Wong JGX, et al. Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, singapore. Am J Trop Med Hyg 2015;92:999-1005. https://doi.org/10.4269/ajtmh.14-0628
  18. Halsey ES, Marks MA, Gotuzzo E, Fiestas V, Suarez L, Vargas J, et al. Correlation of serotype-specific dengue virus infection with clinical manifestations. PLoS Negl Trop Dis 2012;6:e1638. https://doi.org/10.1371/journal.pntd.0001638
  19. Korea Centers for Disease Control and Prevention. Detection of dengue virus gene from mosquito collected in Incheon via mosquito surveillance program: for press release [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; 2019 [cited 2019 Jul 25]. Available from: http://www.cdc.go.kr/board.es?mid=a20501000000&bid=0015&act=view&list_no=364502.
  20. Lee H, Kim JE, Lee S, Lee CH. Potential effects of climate change on dengue transmission dynamics in Korea. PLoS One 2018;13:e0199205. https://doi.org/10.1371/journal.pone.0199205