대한두개안면성형외과학회지 (Archives of Craniofacial Surgery)

  • 제21권4호
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  • Pages.211-218
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  • 2020
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  • 2287-1152(pISSN)
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  • 2287-5603(eISSN)
대한두개안면성형외과학회 (Korean Cleft Palate-Craniofacial Association)
권호 표지
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Fat grafts enriched with adipose-derived stem cells

  • Hong, Ki Yong (Department of Plastic and Reconstructive Surgery, Dongguk University Ilsan Hospital)
  • 투고 : 2020.07.09
  • 심사 : 2020.07.22
  • 발행 : 2020.08.20
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초록

Autologous fat grafts are widely used in soft-tissue augmentation and reconstruction. To reduce the unpredictability of fat grafts and to improve their long-term survival, cell-assisted lipotransfer (CAL) was introduced. In this alternative method, autologous fat is mixed and grafted with stromal vascular fraction cells or adipose-derived stem/stromal cells (ASCs). In regenerative medicine, ASCs exhibit excellent therapeutic potential and are also simple to harvest. Although the efficacy of CAL has been demonstrated in experimental and clinical research, studies on its safety in terms of oncologic risk have reported inconclusive results. In order to establish CAL as a viable stem cell therapeutic approach, it will be necessary to demonstrate its oncologic safety in basic and clinical studies. Doing so could transform the paradigm of clinical strategy and practice for the treatment of a wide variety of diseases.

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참고문헌

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