References
- Tsuyuki S, Fukui S, Watanabe A, Akune S, Tanabe M, Yoshida K. Delphinidin induces autolysosome as well as autophagosome formation and delphinidin-induced autophagy exerts a cell protective role. J Biochem Mol Toxicol. 2012;26:445-453. https://doi.org/10.1002/jbt.21443
- Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL. Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod. 1999;62:294-296. https://doi.org/10.1021/np980501m
- Kim B, Lee SG, Park YK, Ku CS, Pham TX, Wegner CJ, Yang Y, Koo SI, Chun OK, Lee JY. Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in dietinduced obesity mice. Nutr Res Pract. 2016;10:494-500. https://doi.org/10.4162/nrp.2016.10.5.494
- Kasten-Pisula U, Windhorst S, Dahm-Daphi J, Mayr G, Dikomey E. Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. Radiother Oncol. 2007;83:296-303. https://doi.org/10.1016/j.radonc.2007.04.024
- Bump EA, Hoffman SJ, Foye WO. Radiosensitizers and radioprotective agents. In: Abraham DJ, editor. Burger's medicinal chemistry and drug discovery. 6th ed. Hoboken (NJ): Wiley; 2003. p.151-214.
- Nambiar D, Rajamani P, Singh RP. Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy. Mutat Res. 2011;728:139-157. https://doi.org/10.1016/j.mrrev.2011.07.005
-
Kim MH, Jeong YJ, Cho HJ, Hoe HS, Park KK, Park YY, Choi YH, Kim CH, Chang HW, Park YJ, Chung IK, Chang YC. Delphinidin inhibits angiogenesis through the suppression of HIF-
$1{\alpha}$ and VEGF expression in A549 lung cancer cells. Oncol Rep. 2017;37:777-784. https://doi.org/10.3892/or.2016.5296 - Jeong MH, Ko H, Jeon H, Sung GJ, Park SY, Jun WJ, Lee YH, Lee J, Lee SW, Yoon HG, Choi KC. Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells. Oncotarget. 2016;7:56767-56780. https://doi.org/10.18632/oncotarget.10790
- Chen J, Zhou J, Li F, Zhu Y, Zhang W, Yu X. [Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42:264-270. Chinese.
- Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42. https://doi.org/10.1016/j.cell.2007.12.018
- Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy. 2007;3:28-31. https://doi.org/10.4161/auto.3269
- Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy. 2006;2:85-90. https://doi.org/10.4161/auto.2.2.2463
- Bialik S, Dasari SK, Kimchi A. Autophagy-dependent cell death - where, how and why a cell eats itself to death. J Cell Sci. 2018;131:jcs215152. https://doi.org/10.1242/jcs.215152
- Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23:2891-2906. https://doi.org/10.1038/sj.onc.1207521
- Kim TH, Kim HS, Kang YJ, Yoon S, Lee J, Choi WS, Jung JH, Kim HS. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-410. https://doi.org/10.1016/j.bbagen.2014.11.007
- Mohammadpour R, Safarian S, Ejeian F, Sheikholya-Lavasani Z, Abdolmohammadi MH, Sheinabi N. Acetazolamide triggers death inducing autophagy in T-47D breast cancer cells. Cell Biol Int. 2014;38:228-238. https://doi.org/10.1002/cbin.10197
- Kulkarni YM, Kaushik V, Azad N, Wright C, Rojanasakul Y, O'Doherty G, Iyer AK. Autophagy-induced apoptosis in lung cancer cells by a novel digitoxin analog. J Cell Physiol. 2016;231:817-828. https://doi.org/10.1002/jcp.25129
- Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006;10:51-64. https://doi.org/10.1016/j.ccr.2006.06.001
- Liu L, Liao JZ, He XX, Li PY. The role of autophagy in hepatocellular carcinoma: friend or foe. Oncotarget. 2017;8:57707-57722. https://doi.org/10.18632/oncotarget.17202
- Feng R, Wang SY, Shi YH, Fan J, Yin XM. Delphinidin induces necrosis in hepatocellular carcinoma cells in the presence of 3-methyladenine, an autophagy inhibitor. J Agric Food Chem. 2010;58:3957-3964. https://doi.org/10.1021/jf9025458
- Lee DY, Park YJ, Hwang SC, Kim KD, Moon DK, Kim DH. Cytotoxic effects of delphinidin in human osteosarcoma cells. Acta Orthop Traumatol Turc. 2018;52:58-64. https://doi.org/10.1016/j.aott.2017.11.011
- Chen J, Zhu Y, Zhang W, Peng X, Zhou J, Li F, Han B, Liu X, Ou Y, Yu X. Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells. BMC Cancer. 2018;18:342. https://doi.org/10.1186/s12885-018-4231-y
- Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy. 2005;1:84-91. https://doi.org/10.4161/auto.1.2.1697
- Otomo C, Metlagel Z, Takaesu G, Otomo T. Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol. 2013;20:59-66. https://doi.org/10.1038/nsmb.2431
- Mizushima N. Transgenic models of autophagy. In: Deretic V, editor. Autophagy in immunity and infection: a novel immune effector. Weinheim: Wiley-VCH; 2006. p.55-67.
- Hafeez BB, Siddiqui IA, Asim M, Malik A, Afaq F, Adhami VM, Saleem M, Din M, Mukhtar H. A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling. Cancer Res. 2008;68:8564-8572. https://doi.org/10.1158/0008-5472.CAN-08-2232
- Crighton D, Wilkinson S, Ryan KM. DRAM links autophagy to p53 and programmed cell death. Autophagy. 2007;3:72-74. https://doi.org/10.4161/auto.3438
- Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 2006;126:121-134. https://doi.org/10.1016/j.cell.2006.05.034
- Wilkinson MG, Millar JB. Control of the eukaryotic cell cycle by MAP kinase signaling pathways. FASEB J. 2000;14:2147-2157. https://doi.org/10.1096/fj.00-0102rev
- Mizushima N. Autophagy: process and function. Genes Dev. 2007;21:2861-2873. https://doi.org/10.1101/gad.1599207
- Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res. 2014;74:647-651. https://doi.org/10.1158/0008-5472.CAN-13-2966
- Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, Wang X, He C, Pan H. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013;4:e838. https://doi.org/10.1038/cddis.2013.350
- Notte A, Leclere L, Michiels C. Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol. 2011;82:427-434. https://doi.org/10.1016/j.bcp.2011.06.015
- Liu Q, Wang JJ, Pan YC, Meng LF, Zhan X, Zheng QF. [Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer]. Ai Zheng. 2008;27:25-29. Chinese.
- Jiang ZF, Shao LJ, Wang WM, Yan XB, Liu RY. Decreased expression of Beclin-1 and LC3 in human lung cancer. Mol Biol Rep. 2012;39:259-267. https://doi.org/10.1007/s11033-011-0734-1
- Fu LL, Cheng Y, Liu B. Beclin-1: autophagic regulator and therapeutic target in cancer. Int J Biochem Cell Biol. 2013;45:921-924. https://doi.org/10.1016/j.biocel.2013.02.007
- Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C. Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer. Biomed Res Int. 2014;2014:462658. https://doi.org/10.1155/2014/462658
- Karagounis IV, Kalamida D, Mitrakas A, Pouliliou S, Liousia MV, Giatromanolaki A, Koukourakis MI. Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. Br J Cancer. 2016;115:312-321. https://doi.org/10.1038/bjc.2016.202
- Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol. 2006;65:423-432. https://doi.org/10.1097/01.jnen.0000229233.75253.be
- Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 2012;45:487-498. https://doi.org/10.1111/j.1365-2184.2012.00845.x
- Huang P, Han J, Hui L. MAPK signaling in inflammation-associated cancer development. Protein Cell. 2010;1:218-226. https://doi.org/10.1007/s13238-010-0019-9
- Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 2002;12:9-18. https://doi.org/10.1038/sj.cr.7290105
- Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012;92:689-737. https://doi.org/10.1152/physrev.00028.2011
- Reddy KB, Nabha SM, Atanaskova N. Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev. 2003;22:395-403. https://doi.org/10.1023/A:1023781114568
- Burotto M, Chiou VL, Lee JM, Kohn EC. The MAPK pathway across different malignancies: a new perspective. Cancer. 2014;120:3446-3456. https://doi.org/10.1002/cncr.28864
- Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, He C, Pan H. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 2014;344:174-179. https://doi.org/10.1016/j.canlet.2013.11.019
- Wong CH, Iskandar KB, Yadav SK, Hirpara JL, Loh T, Pervaiz S. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One. 2010;5:e9996. https://doi.org/10.1371/journal.pone.0009996
- Shajahan AN, Dobbin ZC, Hickman FE, Dakshanamurthy S, Clarke R. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). J Biol Chem. 2012;287:17682-17692. https://doi.org/10.1074/jbc.M111.304022
- Tian PG, Jiang ZX, Li JH, Zhou Z, Zhang QH. Spliced XBP1 promotes macrophage survival and autophagy by interacting with Beclin-1. Biochem Biophys Res Commun. 2015;463:518-523. https://doi.org/10.1016/j.bbrc.2015.05.061
Cited by
- The Hallmarks of Flavonoids in Cancer vol.26, pp.7, 2020, https://doi.org/10.3390/molecules26072029
- UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway vol.69, pp.5, 2020, https://doi.org/10.1136/jim-2020-001736
- Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives vol.22, pp.21, 2021, https://doi.org/10.3390/ijms222111500