A case study of gait disturbance on early stage MSA-C treated with Korean Medicine

보행장애를 호소하는 초기 다계통 위축증(MSA-C) 환자 한의 치험 1례

  • Choi, Jeong-Woo (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Seo-Young (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Ha-Ri (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jeon, Gyu-Ri (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Cho, Seung-Yeon (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Seong-Uk (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Jung-Mi (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ko, Chang-Nam (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 최정우 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 김서영 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 김하리 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 전규리 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 조승연 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박성욱 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박정미 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 고창남 (경희대학교 대학원 한방순환신경내과학교실)
  • Published : 2020.12.01

Abstract

■ Objectives The purpose of this case is to report the effectiveness of Korean medicine in the treatment of early stage multiple system atrophy-cerebellar ataxia(MSA-C) ■ Methods The patient was treated with acupuncture, bee venom, and herbal medicine. The clinical symptoms was assessed using unified multiple system atrophy rating scale(UMSARS) and 20M gait time and steps. ■ Results After treatment, UMSARS score and 20M gait time and steps showed improvement. ■ Conclusion This study suggested that Korean medical treatment could be an effective option for treating early stage MSA-C.

Keywords

References

  1. Quinn N. Multiple system atrophy - the nature of the beast. J Neurol Neurosurg Psychiatry. 1989. Suppl:78-89
  2. Schrag A, Ben-Shlomo Y, Quinn NP. Prevalence of progressive supranuclear palsy and multiple system atrophy: a crosssectional study. Lancet. 1999;354:1771-5 https://doi.org/10.1016/S0140-6736(99)04137-9
  3. Rey MV, Perez-Lloret S, Pavy-Le Traon A, et al. A cross-sectional study on drug use in multiple system atrophy. CNS Drugs. 2014;28:483-490 https://doi.org/10.1007/s40263-014-0159-1
  4. Kim SY, Choi JW, Jeong HS, et al. A Case of Multiple System Atrophy with Antecollis and Gait Disturbance Treated with Korean Medicine. J Int Korean Med. 2019;40(5):851-864 https://doi.org/10.22246/jikm.2019.40.5.851
  5. Cho JH, Lim BR, Jeong TS, et al. A Case Report of a Multiple System Atrophy-C Patient Treated by Korean Medicine. J Int Korean Med. 2018;39(5):1042-1051 https://doi.org/10.22246/jikm.2018.39.5.1042
  6. Jung MH, Son JH, Cho JH, et al. A Case Study of Multiple System Atrophy Patient with Diplopia Using Korean Medical Treatment. J Int Korean Med. 2017;38(2):246-251 https://doi.org/10.22246/jikm.2017.38.2.246
  7. Woo SJ, Baek KM, Jang WS. A Case Report of Multiple System Atrophy in a Cerebellar Ataxia Patient Suffering from Gait Disturbance Treated with Korean Medicine. J Int Korean Med. 2016;37(5):806-814 https://doi.org/10.22246/jikm.2016.37.5.806
  8. Wenning GK, Tison F, Seppi K, et al. Development and validation of the Unified Multiple system atrophy rating scale(UMSARS). Movement Disorders. 2004;19:1391-1402 https://doi.org/10.1002/mds.20255
  9. Wenning GK, Geser F, Krismer F, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol. 2013;12:264-274 https://doi.org/10.1016/S1474-4422(12)70327-7
  10. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71:670-676 https://doi.org/10.1212/01.wnl.0000324625.00404.15
  11. Yu H, Yuan X, Liu L, et al. Treatment of multiple system atrophy - the past, present and future. Am J Clin Exp Immunol. 2018;7(5):88-94
  12. Zheng W, Ren S, Zhang H, et al. Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study. Front Neurosci. 2019;31(13):777 https://doi.org/10.3389/fnins.2019.00777
  13. Wang F, Jia SW. Effect of acupuncture on regional cerebral blood flow and cerebral functional activity evaluated with single-photon emission computed tomography. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(6):340-3
  14. Ding N, Jiang J, Xu A, et al. Manual Acupuncture Regulates Behavior and Cerebral Blood Flow in the SAMP8 Mouse Model of Alzheimer's Disease. Front. Neurosci. 2018;13:37 https://doi.org/10.3389/fnins.2019.00037
  15. Park SJ, Lee HY, Yoon TH, et al. Effect of Scolopendrid Calculus Bovis-Fel Uris-Moschus Bee Venom and Sweet Bee Venom on Regional Cerebral Blood Flow after Pharmacopuncture to GV16 Pungbu and GB20 Pungji in Rat. J Pharmacopuncture. 2012;15(4):25-31 https://doi.org/10.3831/KPI.2012.15.014
  16. 송일병, 홍남두, 김남재 등. 生藥 複合 製劑의藥效 硏究(第27報) - 淸血降氣湯의 藥效에 관한 實驗的 硏究. 생약학회지. 1986;17(2):113-22
  17. Krismer F, Seppi K, Wenning GK, et al. Minimally clinically important decline in the parkinsonian variant of multiple system atrophy. Movement Disorders 2016;31(10):1577-1581 https://doi.org/10.1002/mds.26743