The Journal of the Society of Stroke on Korean Medicine (대한중풍순환신경학회지)

The Society of Stroke on Korean Medicine (대한중풍순환신경학회)
권호 표지

A Case Report of Guillain-Barré Syndrome with Neutropenia Improved by Combined Korean Medicine Treatment

호중구 감소를 동반한 길랑바레 증후군에 대한 한의 복합 치료 증례보고 1례

  • Jung, Eun-sun (Department of Circulatory Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Yoo, Ho-ryong (Department of Circulatory Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Kim, Yoon-sik (Department of Circulatory Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Seol, In-chan
  • 정은선 (대전대학교 한의과대학 심계내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 심계내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 심계내과학교실) ;
  • 설인찬 (대전대학교 대전한방병원)
  • Published : 2020.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

■ Objectives This study reports a case of improvement in a patient with neutropenia after Guillain-Barré treatment through combined Korean medicine treatment. ■ Methods This patient was hospitalized for 22 days and was treated by herbal medicine, electroacupuncture, and physical therapy. Symptom improvement was evaluated through periodic clinical pathology examination, manual muscle test(MMT), yanagihara scale, and numeric rastic sclae(NRS). ■ Results The clinical symptoms and absolute neutrophil counts of this Guillain-Barré patient improved after the combined Korean medicine therapy treatment. ■ Conclusion This study suggests that Korean Medicine can be effective in reducing Guillain-Barre syndrome symptoms and improving intravenous immunogloubulin induced neutropenia, but more research is required to confirm these results.

본 증례보고는 GBS를 진단받고 IVIg치료 후 호중구 감소증이 동반된 환자를 위증(痿證)으로 변증하여 한약, 침구치료, 물리치료를 통해 환자의 증상 호전을 보였기에 보고하는 바이다.

Keywords

References

  1. Yuki N, Hartung H-P. Guillain-Barre syndrome. N Engl J Med. 2012;366(24):2294-304. https://doi.org/10.1056/NEJMra1114525
  2. Willison HJ, Jacobs BC, Van Doorn PA. Guillain-barre syndrome. Lancet. 2016;388 (10045):717-27. https://doi.org/10.1016/S0140-6736(16)00339-1
  3. Park SM, Cho SW. A Case of Combined Korean Medicine Treatment for Recurrent Limb Weakness after Guillain-Barre Syndrome Improvement: Case Report. J Korean Med Rehabil. 2019;29(4):135-42.
  4. Hwang DG, Park SM, Kim EJ, et al. Case Report of Patients Diagnosed with Guillain-Barre Syndrome Improved by Traditional Korean Medical Treatment. J Int Korean Med. 2016;37(2):305-14.
  5. Lee YR, Kim, HS Choi, et al. A Case Report of Patient with Guillain-Barre Syndrome Complaining of Fatigue and Tingling Improved by Korean Medicine Treatment. J Int Korean Med. 2017;38(5):719-26. https://doi.org/10.22246/jikm.2017.38.5.719
  6. Lee HS, Kim DR, Shim SS, et al. A Case Report on a Patient with Guillain-Barre Syndrome Complaining of Quadriplegia and Paresthesia, Which Improved after Korean Medicine Treatment. J Int Korean Med. 2019;40(6):1210-18. https://doi.org/10.22246/jikm.2019.40.6.1210
  7. Tatjana PS , Martina GS, Martin P. Reliability and validity of the Medical Research Council MRC) scale and a modified scale for testing muscle strength in patients with radial palsy. J Rehabil Med. 2008;40(8):665-71. https://doi.org/10.2340/16501977-0235
  8. Kwon HY, Cho TS, Son IS, et al. The Evaluation of Improvement of Bell's Palsy by Yanagihara's System. Journal of Acupuncture Research 2002:19(1):118-26.
  9. Jasti AK, Selmi C, Sarmiento-Monroy JC, et al. Guillain-Barre syndrome: causes, immunopathogenic mechanisms and treatment. Expert review of clinical immunology. 2016;12(11):1175-89. https://doi.org/10.1080/1744666X.2016.1193006
  10. Guo Y, Tian X, Wang X, et al., Adverse effects of immunoglobulin therapy. Front immunol. 2018;9:1299. https://doi.org/10.3389/fimmu.2018.01299
  11. Matsuda M, Hosoda W, SekijimaY, et al. Neutropenia as a complication of high-dose intravenous immunoglobulin therapy in adult patients with neuroimmunologic disorders. Clin neuropharmacol. 2003;26(6):306-11. https://doi.org/10.1097/00002826-200311000-00009
  12. von Gunten S, Simon HU. Natural anti-Siglec auto antibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg). Autoimmunity reviews. 2008;7(6):453-56. https://doi.org/10.1016/j.autrev.2008.03.015
  13. Altznauer F, von Gunten S, Spath P, et al. Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations. J Allergy Clin Immunol. 2003;112(6):1185-90. https://doi.org/10.1016/j.jaci.2003.09.045
  14. Kim HJ, Lee EJ, Chang GT, et al. A Literature Study on Treatment of Guillain-Barre Syndrome Based on Traditional Chinese Medicine Journals. J Pediatr Korean Med. 2015;29(3):21-31. https://doi.org/10.7778/jpkm.2015.29.3.021
  15. Kasper DL, Fauci AS, Longo DL, et al. Harrison's priciples of Internal Medicine. 19th edition. Seoul:MIC. 2017:453-7.
  16. US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Published May 28, 2009(v4.03: June 14, 2010).
  17. Kim MS, Jumg YJ, Hong SH. Clinical effectiveness of traditional herbal medicine in the treatment of chemotherapy-induced leukopenia: a systematic review and meta-analysis of randomized clinical trials. J Int Korean Med. 2018;39(4):520-49. https://doi.org/10.22246/jikm.2018.39.4.520
  18. Ko SG, Jung YS, Bu SA, et al. A Bibliographical Study of Chinese Medical Journals regarding the Treatment of Leucopenia, Occurred after Radiotherapy and Chemotherapy Treatment of Cancer Patients. J Int Korean Med. 2002;23(1):117-22.
  19. Jung HK, Hyeon KS. Analysis of Biological Experiment on Immunoactivity of Sipjeondabo-tang. Physiol Pathol Korean Med. 2012;26(5):641-9.