The Korean journal of internal medicine

  • 제35권2호
  • /
  • Pages.369-382
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  • 2020
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지
DOI QR코드

DOI QR Code

Effects of cigarette smoking on blood lipids in Korean men: Cardiovascular and Metabolic Diseases Etiology Research Center cohort

  • Kim, Soo Kyoung (Department of Public Health, Yonsei University Graduate School) ;
  • Kim, Hyeon Chang (Department of Public Health, Yonsei University Graduate School) ;
  • Shim, Jee-Seon (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Kim, Dae Jung (Department of Endocrinology and Metabolism, Ajou University School of Medicine)
  • 투고 : 2019.04.19
  • 심사 : 2019.08.27
  • 발행 : 2020.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Cigarette smoking and abnormal blood lipids are major risk factors for cardiovascular disease. The results of previous studies on the relationship between cigarette smoking and dyslipidemia are controversial. In the present study, we investigated the independent association between cigarette smoking and blood lipid levels in a male Korean population. Methods: A total of 1,932 men aged from 30 to 64 years old participated in the Cardiovascular and Metabolic Diseases Etiology Research Center cohort study. Smoking history was obtained by in-person interviews. In all regression models, measurements of triglyceride levels were log-transformed. Results: Triglyceride levels were higher in current smokers than in never-smokers (median: 149 mg/dL vs. 115 mg/dL, p < 0.001) even after adjusting age, body mass index, alcohol intake, systolic blood pressure, fasting glucose, physical activity, and nutrition intake (β = 0.14, p < 0.001). We further divided people into heavy and light smokers using 20 pack-years as the cut-off. Higher triglyceride were found in current heavy smokers (β = 0.18, p < 0.001), current light smokers (β = 0.13, p < 0.001), as well as in past heavy smokers (β = 0.08, p = 0.037), as compared to never-smokers. Moreover, significantly lower high-density lipoprotein cholesterol (HDL-C) were observed in current heavy smokers (β = -2.27 mg/dL, p = 0.009). Conclusions: Cigarette smoking is associated with higher triglyceride in Korean men, with the most dramatic effect seen in current smokers with a smoking history of more than 20 pack-years. HDL-C were also lower in current smokers with more than 20 pack-years.

키워드

과제정보

This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant no. HI13C0715).

참고문헌

  1. Grundy SM, Becker D, Clark LT, et al. Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda (MD): National Institutes of Health, 2002:1-28.
  2. McGill HC Jr, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol 1997;17:95-106. https://doi.org/10.1161/01.ATV.17.1.95
  3. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA 1986;256:2835-2838. https://doi.org/10.1001/jama.1986.03380200073024
  4. Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation 1992;85:37-45. https://doi.org/10.1161/01.CIR.85.1.37
  5. Kannel WB. Some lessons in cardiovascular epidemiology from Framingham. Am J Cardiol 1976;37:269-282. https://doi.org/10.1016/0002-9149(76)90323-4
  6. Hammond EC, Horn D. Landmark article March 15, 1958: Smoking an d death rates: report on forty-four months of follow-up of 187,783 men. By E. Cuyler Hammond and Daniel Horn. JAMA 1984;251:2840-2853. https://doi.org/10.1001/jama.1984.03340450056029
  7. Pasupathi P, Rao YY, Farook J, Saravanan G, Bakthavathsalam G. Effect of cigarette smoking on lipids and oxidative stress biomarkers in patients with acute myocardial infarction. Res J Med Med Sci 2009;4:151-159.
  8. Garrison RJ, Kannel WB, Feinleib M, Castelli WP, McNamara PM, Padgett SJ. Cigarette smoking and HDL cholesterol: the Framingham offspring study. Atherosclerosis 1978;30:17-25. https://doi.org/10.1016/0021-9150(78)90149-1
  9. Freeman DJ, Griffin BA, Murray E, et al. Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. Eur J Clin Invest 1993;23:630-640. https://doi.org/10.1111/j.1365-2362.1993.tb00724.x
  10. Ludicke F, Magnette J, Baker G, Weitkunat R. A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers. Biomarkers 2015;20:411-421. https://doi.org/10.3109/1354750X.2015.1096303
  11. The Korean Society of Lipid and Atherosclerosis. Dyslipidemia Fact Sheets in Korea, 2018. Seoul (KR): The Korean Society of Lipid and Atherosclerosis, 2018.
  12. Organization for Economic Cooperation and Development. Health at a Glance 2017 [Internet]. Paris (FR): OECD, c2019 [cited 2019 Nov 14]. Available from: https://doi.org/10.1787/health_glance-2017-en.
  13. Shim JS, Song BM, Lee JH, et al. Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment. Epidemiol Health 2017;39:e2017016. https://doi.org/10.4178/epih.e2017016
  14. Office of the Surgeon General; Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report Of The Surgeon General. Rockville (MD): Centers for Disease Control & Prevention, 2010.
  15. Hughes JR, Peters EN, Naud S. Relapse to smoking after 1 year of abstinence: a meta-analysis. Addict Behav 2008;33:1516-1520. https://doi.org/10.1016/j.addbeh.2008.05.012
  16. Pastorino U, Bellomi M, Landoni C, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003;362:593-597. https://doi.org/10.1016/S0140-6736(03)14188-8
  17. Hassan MM, Phan A, Li D, Dagohoy CG, Leary C, Yao JC. Risk factors associated with neuroendocrine tumors: a U.S.-based case-control study. Int J Cancer 2008;123:867-873. https://doi.org/10.1002/ijc.23529
  18. Anandha Lakshmi S, Lakshmanan A, Ganesh Kumar P, Saravanan A. Effect of intensity of cigarette smoking on haematological and lipid parameters. J Clin Diagn Res 2014;8:BC11- BC13.
  19. Neumann T, Rasmussen M, Heitmann BL, Tonnesen H. Gold standard program for heavy smokers in a real-life setting. Int J Environ Res Public Health 2013;10:4186-4199. https://doi.org/10.3390/ijerph10094186
  20. Kweon S, Kim Y, Jang MJ, et al. Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 2014;43:69-77. https://doi.org/10.1093/ije/dyt228
  21. IPAQ Research Committee. Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ)-short and long forms [Internet]. IPAQ, 2019 [cited 2019 Nov 14]. Available from: http://www.ipaq.ki.se.
  22. Oh JY, Yang YJ, Kim BS, Kang JH. Validity and reliability of Korean version of International Physical Activity Questionnaire (IPAQ) short form. J Korean Acad Fam Med 2007;28:532-541.
  23. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502. https://doi.org/10.1093/clinchem/18.6.499
  24. Lenth RV. Least-squares means: the R package lsmeans. J Stat Softw 2016;69:1-33. https://doi.org/10.18637/jss.v069.i01
  25. Billimoria JD, Pozner H, Metselaar B, Best FW, James DC. Effect of cigarette smoking on lipids, lipoproteins, blood coagulation, fibrinolysis and cellular components of human blood. Atherosclerosis 1975;21:61-76. https://doi.org/10.1016/0021-9150(75)90094-5
  26. Lee MH, Ahn SV, Hur NW, Choi DP, Kim HC, Suh I. Gender differences in the association between smoking and dyslipidemia: 2005 Korean National Health and Nutrition Examination Survey. Clin Chim Acta 2011;412:1600-1605. https://doi.org/10.1016/j.cca.2011.05.013
  27. Sharma SB, Dwivedi S, Prabhu KM, Singh G, Kumar N, Lal MK. Coronary risk variables in young asymptomatic smokers. Indian J Med Res 2005;122:205-210.
  28. Brischetto CS, Connor WE, Connor SL, Matarazzo JD. Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families: enhancement of hyperlipidemia and depression of high-density lipoprotein. Am J Cardiol 1983;52:675-680. https://doi.org/10.1016/0002-9149(83)90396-X
  29. Taylor KG, Carter TJ, Valente AJ, Wright AD, Smith JH, Matthews KA. Sex differences in the relationships between obesity, alcohol consumption and cigarette smoking and serum lipid and apolipoprotein concentrations in a normal population. Atherosclerosis 1981;38:11-18. https://doi.org/10.1016/0021-9150(81)90098-8
  30. Axelsen M, Eliasson B, Joheim E, Lenner RA, Taskinen MR, Smith U. Lipid intolerance in smokers. J Intern Med 1995;237:449-455. https://doi.org/10.1111/j.1365-2796.1995.tb00869.x
  31. Hautanen A, Adlercreutz H. Hyperinsulinaemia, dyslipidaemia and exaggerated adrenal androgen response to adrenocorticotropin in male smokers. Diabetologia 1993;36:1275-1281. https://doi.org/10.1007/BF00400805
  32. Kuzuya M, Ando F, Iguchi A, Shimokata H. Effect of smoking habit on age-related changes in serum lipids: a cross-sectional and longitudinal analysis in a large Japanese cohort. Atherosclerosis 2006;185:183-190. https://doi.org/10.1016/j.atherosclerosis.2005.05.040
  33. Meenakshisundaram R, Rajendiran C, Thirumalaikolundusubramanian P. Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India. Tob Induc Dis 2010;8:11. https://doi.org/10.1186/1617-9625-8-11
  34. Kume A, Kume T, Masuda K, Shibuya F, Yamazaki H. Dose-dependent effects of cigarette smoke on blood biomarkers in healthy Japanese volunteers: observations from smoking and non-smoking. J Health Sci 2009;55:259-264. https://doi.org/10.1248/jhs.55.259
  35. Yoon C, Goh E, Park SM, Cho B. Effects of smoking cessation and weight gain on cardiovascular disease risk factors in Asian male population. Atherosclerosis 2010;208:275-279. https://doi.org/10.1016/j.atherosclerosis.2009.07.024
  36. Moriguchi EH, Fusegawa Y, Tamachi H, Goto Y. Effects of smoking on HDL subfractions in myocardial infarction patients: effects on lecithin-cholesterol acyltransferase and hepatic lipase. Clin Chim Acta 1991;195:139-143. https://doi.org/10.1016/0009-8981(91)90134-X
  37. McCall MR, van den Berg JJ, Kuypers FA, et al. Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk. Arterioscler Thromb 1994;14:248-253. https://doi.org/10.1161/01.ATV.14.2.248
  38. Craig WY, Palomaki GE, Haddow JE. Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data. BMJ 1989;298:784-788. https://doi.org/10.1136/bmj.298.6676.784
  39. Contaldo F, D'Arrigo E, Carandente V, et al. Short-term effects of moderate alcohol consumption on lipid metabolism and energy balance in normal men. Metabolism 1989;38:166-171. https://doi.org/10.1016/0026-0495(89)90257-6
  40. Crouse JR, Grundy SM. Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. J Lipid Res 1984;25:486-496. https://doi.org/10.1016/S0022-2275(20)37800-7
  41. Vriz O, Nesbitt S, Krause L, Majahalme S, Lu H, Julius S. Smoking is associated with higher cardiovascular risk in young women than in men: the Tecumseh Blood Pressure Study. J Hypertens 1997;15:127-134. https://doi.org/10.1097/00004872-199715020-00002
  42. Namekata T, Moore DE, Suzuki K, et al. Biological and lifestyle factors, and lipid and lipoprotein levels among Japanese Americans in Seattle and Japanese men in Japan. Int J Epidemiol 1997;26:1203-1213. https://doi.org/10.1093/ije/26.6.1203
  43. Ma Y, Li Y, Chiriboga DE, et al. Association between carbohydrate intake and serum lipids. J Am Coll Nutr 2006;25:155-163. https://doi.org/10.1080/07315724.2006.10719527
  44. Foster GD, Wyatt HR, Hill JO, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003;348:2082-2090. https://doi.org/10.1056/NEJMoa022207
  45. Merchant AT, Anand SS, Kelemen LE, et al. Carbohydrate intake and HDL in a multiethnic population. Am J Clin Nutr 2007;85:225-230. https://doi.org/10.1093/ajcn/85.1.225
  46. Song S, Lee JE, Song WO, Paik HY, Song Y. Carbohydrate intake and refined-grain consumption are associated with metabolic syndrome in the Korean adult population. J Acad Nutr Diet 2014;114:54-62. https://doi.org/10.1016/j.jand.2013.08.025
  47. Jung SJ, Kim MG, Park TS, Kim YG, Song WO, Chae SW. Rice-based Korean meals (bibimbap and kimbap) have lower glycemic responses and postprandial-triglyceride effects than energy-matched Western meals. J Ethn Foods 2015;2:154-161. https://doi.org/10.1016/j.jef.2015.11.002
  48. Choi H, Song S, Kim J, et al. High carbohydrate intake was inversely associated with high-density lipoprotein cholesterol among Korean adults. Nutr Res 2012;32:100-106. https://doi.org/10.1016/j.nutres.2011.12.013
  49. Freedman DS, Srinivasan SR, Shear CL, et al. Cigarette smoking initiation and longitudinal changes in serum lipids and lipoproteins in early adulthood: the Bogalusa Heart Study. Am J Epidemiol 1986;124:207-219. https://doi.org/10.1093/oxfordjournals.aje.a114379
  50. Chelland Campbell S, Moffatt RJ, Stamford BA. Smoking and smoking cessation: the relationship between cardiovascular disease and lipoprotein metabolism: a review. Atherosclerosis 2008;201:225-235. https://doi.org/10.1016/j.atherosclerosis.2008.04.046
  51. Gepner AD, Piper ME, Johnson HM, Fiore MC, Baker TB, Stein JH. Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial. Am Heart J 2011;161:145-151. https://doi.org/10.1016/j.ahj.2010.09.023
  52. Freeman DJ, Caslake MJ, Griffin BA, et al. The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma. Eur J Clin Invest 1998;28:584-591. https://doi.org/10.1046/j.1365-2362.1998.00328.x
  53. Tverdal A, Thelle D, Stensvold I, Leren P, Bjartveit K. Mortality in relation to smoking history: 13 years' follow-up of 68,000 Norwegian men and women 35-49 years. J Clin Epidemiol 1993;46:475-487. https://doi.org/10.1016/0895-4356(93)90025-V
  54. Celermajer DS, Adams MR, Clarkson P, et al. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 1996;334:150-154. https://doi.org/10.1056/NEJM199601183340303
  55. He J, Vupputuri S, Allen K, Prerost MR, Hughes J, Whelton PK. Passive smoking and the risk of coronary heart disease: a meta-analysis of epidemiologic studies. N Engl J Med 1999;340:920-926. https://doi.org/10.1056/NEJM199903253401204
  56. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998;81:7B-12B. https://doi.org/10.1016/S0002-9149(98)00031-9
  57. Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007;115:450-458. https://doi.org/10.1161/CIRCULATIONAHA.106.637793

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