한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제30권2호
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  • Pages.196-204
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  • 2020
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  • 2384-132X(pISSN)
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  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지
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만성폐쇄성폐질환을 동반한 이직광부에서 혈장 총 Peroxide 및 산화스트레스 지수 수준에 미치는 영향요인

Influencing Factors of Plasma Levels of Total Peroxide and Oxidative Stress Index in Retired Miners with Chronic Obstructive Pulmonary Disease

  • 이종성 (근로복지공단 직업환경연구원) ;
  • 신재훈 (근로복지공단 직업환경연구원) ;
  • 백진이 (근로복지공단 직업환경연구원) ;
  • 정지영 (동아대학교 의약생명공학과) ;
  • 최병순 (근로복지공단 직업환경연구원)
  • Lee, Jong Seong (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Shin, Jae Hoon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Baek, Jin Ee (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Jeong, Ji Yeong (Department of Medical Biotechnology, Dong-A University) ;
  • Choi, Byung-Soon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service)
  • 투고 : 2020.05.11
  • 심사 : 2020.06.21
  • 발행 : 2020.06.30
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초록

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Increasing oxidative stress associated with COPD. The aim of this study was to evaluate the influencing factors of biomarkers for oxidative stress in retired miners with COPD. Methods: The levels of total peroxide(TPx), total antioxidant capacity(TAC), and oxidative stress index(TPx/TAC ratio, OSI) in plasma as biomarkers for oxidative stress, serum C-reactive protein(CRP) as a biomarker for inflammation, and general characteristics were measured in 93 male subjects with COPD. COPD was defined as post bronchodilator FEV1/FVC<0.7 by spirometry. Results: Mean levels of TPx(p=0.013), TAC(p=0.010), OSI(p=0.040), and CRP(p=0.024) were higher in current smokers. Levels of TPx(β=0.445, p<0.001), TAC(β=0.490, p<0.001), and OSI(β=0.351, p<0.001) were related to CRP levels, and CRP levels were related to %FEV1 predicted(β=-0.295, p=0.003) and current smoking(β=0.214, p=0.032). Conclusions: These results suggest that oxidative stress was related to inflammation, and inflammation were related to decreasing %FEV1 predicted and current smoking in retired miners with COPD.

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