참고문헌
- Agamova KA, Starinskii VV, Nevskaia EA, Gladunova ZD, Nikitina NI. 1987. [The role of cytological studies in evaluating the severity of dysplasia during prophylactic gynecological examinations (cooperative study)]. Vopr. Onkol. 33:53-57. Russian.
- Asahina K, Zhou B, Pu WT, Tsukamoto H. 2011. Septum transversum- derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53:983-995. https://doi.org/10.1002/hep.24119
- Bin WT, Ma LM, Xu Q, Shi XL. 2012. Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action. World J. Gastroenterol. 18:309-322. https://doi.org/10.3748/wjg.v18.i4.309
- Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, Schwabe RF, Hillman EM, Piantedosi R, Libien J. 2009. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim. Biophys. Acta 1791:467-473. https://doi.org/10.1016/j.bbalip.2008.11.001
- Bleriot C and Ginhoux F. 2019. Understanding the heterogeneity of resident liver macrophages. Front. Immunol. 10:2694. https://doi.org/10.3389/fimmu.2019.02694
- Cassiman D, Denef C, Desmet VJ, Roskams T. 2001. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 33:148-158. https://doi.org/10.1053/jhep.2001.20793
- Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. 2002. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J. Hepatol. 36:200-209.
- Chan KM, Fu YH, Wu TJ, Hsu PY, Lee WC. 2013. Hepatic stellate cells promote the differentiation of embryonic stem cellderived definitive endodermal cells into hepatic progenitor cells. Hepatol. Res. 43:648-657. https://doi.org/10.1111/j.1872-034X.2012.01110.x
- De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. 2007. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132:1937-1946. https://doi.org/10.1053/j.gastro.2007.02.033
- Deleve LD, Wang X, Guo Y. 2008. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology 48:920-930. https://doi.org/10.1002/hep.22351
- Friedman SL. 2008. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 88:125-172. https://doi.org/10.1152/physrev.00013.2007
- Gard AL, White FP, Dutton GR. 1985. Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver. J. Neuroimmunol. 8:359-375. https://doi.org/10.1016/S0165-5728(85)80073-4
- Glassner A, Eisenhardt M, Kramer B, Korner C, Coenen M, Sauerbruch T, Spengler U, Nattermann J. 2012. NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasLand NKG2D-dependent manner. Lab. Invest. 92:967-977. https://doi.org/10.1038/labinvest.2012.54
- Greenbaum LE and Wells RG. 2011. The role of stem cells in liver repair and fibrosis. Int. J. Biochem. Cell Biol. 43:222-229. https://doi.org/10.1016/j.biocel.2009.11.006
- Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, Czaja MJ, Friedman SL. 2012. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142:938-946. https://doi.org/10.1053/j.gastro.2011.12.044
- Higashi T, Friedman SL, Hoshida Y. 2017. Hepatic stellate cells as key target in liver fibrosis. Adv. Drug Deliv. Rev. 121:27-42. https://doi.org/10.1016/j.addr.2017.05.007
- Hwang JH, Yuk SH, Lee JH, Lyoo WS, Ghil SH, Lee SS, Khang IG, Paik SY, Lee JY. 2004. Isolation of muscle derived stem cells from rat and its smooth muscle differentiation [corrected]. Mol. Cells 17:57-61.
- Jensen KJ, Alpini G, Glaser S. 2013. Hepatic nervous system and neurobiology of the liver. Compr. Physiol. 3:655-665. https://doi.org/10.1002/cphy.c120018
- Jeong WI, Park O, Gao B. 2008. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 134:248-258. https://doi.org/10.1053/j.gastro.2007.09.034
-
Jeong WI, Park O, Suh YG, Byun JS, Park SY, Choi E, Kim JK, Ko H, Wang H, Miller AM, Gao B. 2011. Suppression of innate immunity (natural killer cell/interferon-
${\gamma}$ ) in the advanced stages of liver fibrosis in mice. Hepatology 53:1342-1351. https://doi.org/10.1002/hep.24190 - Kato M, Kato K, Goodman DS. 1984. Immunocytochemical studies on the localization of plasma and of cellular retinolbinding proteins and of transthyretin (prealbumin) in rat liver and kidney. J. Cell Biol. 98:1696-1704. https://doi.org/10.1083/jcb.98.5.1696
- Khomich O, Ivanov AV, Bartosch B. 2019. Metabolic hallmarks of hepatic stellate cells in liver fibrosis. Cells 9:24. https://doi.org/10.3390/cells9010024
- Kiassov AP, Van Eyken P, van Pelt JF, Depla E, Fevery J, Desmet VJ, Yap SH. 1995. Desmin expressing nonhematopoietic liver cells during rat liver development: an immunohistochemical and morphometric study. Differentiation 59:253-258. https://doi.org/10.1046/j.1432-0436.1995.5940253.x
- Kisseleva T and Brenner DA. 2006. Hepatic stellate cells and the reversal of fibrosis. J. Gastroenterol. Hepatol. 21 Suppl 3:S84-S87. https://doi.org/10.1111/j.1440-1746.2006.04584.x
- Kolios G, Valatas V, Kouroumalis E. 2006. Role of Kupffer cells in the pathogenesis of liver disease. World J. Gastroenterol. 12:7413-7420. https://doi.org/10.3748/wjg.v12.i46.7413
- Kristensen DB, Kawada N, Imamura K, Miyamoto Y, Tateno C, Seki S, Kuroki T, Yoshizato K. 2000. Proteome analysis of rat hepatic stellate cells. Hepatology 32:268-277. https://doi.org/10.1053/jhep.2000.9322
- Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. 2008. Senescence of activated stellate cells limits liver fibrosis. Cell 134:657-667. https://doi.org/10.1016/j.cell.2008.06.049
- Kurokawa T, Zheng YW, Ohkohchi N. 2016. Novel functions of platelets in the liver. J. Gastroenterol. Hepatol. 31:745-751. https://doi.org/10.1111/jgh.13244
- Levy MT, McCaughan GW, Abbott CA, Park JE, Cunningham AM, Muller E, Rettig WJ, Gorrell MD. 1999. Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis. Hepatology 29:1768-1778. https://doi.org/10.1002/hep.510290631
- Levy MT, McCaughan GW, Marinos G, Gorrell MD. 2002. Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. Liver 22:93-101. https://doi.org/10.1034/j.1600-0676.2002.01503.x
- Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M, Karaca G, Xie G, Guy CD, Bohinc B, Lindblom KR, Johnson E, Kornbluth S, Diehl AM. 2015. Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. Gut 64:1148-1157. https://doi.org/10.1136/gutjnl-2014-307362
- Martufi M, Good RB, Rapiteanu R, Schmidt T, Patili E, Tvermosegaard K, New M, Nanthakumar CB, Betts J, Blanchard AD, Maratou K. 2019. Single-step, high-efficiency CRISPRCas9 genome editing in primary human disease-derived fibroblasts. CRISPR J. 2:31-40. https://doi.org/10.1089/crispr.2018.0047
- Mehal WZ, Iredale J, Friedman SL. 2011. Scraping fibrosis: expressway to the core of fibrosis. Nat. Med. 17:552-553. https://doi.org/10.1038/nm0511-552
- Nakatani K, Seki S, Kawada N, Kobayashi K, Kaneda K. 1996. Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver. Cell Tissue Res. 283:159-165. https://doi.org/10.1007/s004410050524
- Novo E, Busletta C, Bonzo LV, Povero D, Paternostro C, Mareschi K, Ferrero I, David E, Bertolani C, Caligiuri A, Cannito S, Tamagno E, Compagnone A, Colombatto S, Marra F, Fagioli F, Pinzani M, Parola M. 2011. Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells. J. Hepatol. 54:964-974. https://doi.org/10.1016/j.jhep.2010.09.022
- Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS, Ibraghimov A. 2005. Attenuated liver fibrosis in the absence of B cells. J. Clin. Invest. 115:3072-3082. https://doi.org/10.1172/JCI24798
- Nowatari T, Murata S, Fukunaga K, Ohkohchi N. 2014. Role of platelets in chronic liver disease and acute liver injury. Hepatol. Res. 44:165-172. https://doi.org/10.1111/hepr.12205
- Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM. 2004. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 53:438-445. https://doi.org/10.1136/gut.2003.026658
- Park O, Jeong WI, Wang L, Wang H, Lian ZX, Gershwin ME, Gao B. 2009. Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49:1683-1694. https://doi.org/10.1002/hep.22813
- Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, Jang MK, Guenther ND, Mederacke I, Friedman R, Dragomir AC, Aloman C, Schwabe RF. 2013. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology 58:1461-1473. https://doi.org/10.1002/hep.26429
- Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP. 2012. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Natl. Acad. Sci. U. S. A. 109:E3186-E3195. https://doi.org/10.1073/pnas.1119964109
- Roskams T, Cassiman D, De Vos R, Libbrecht L. 2004. Neuroregulation of the neuroendocrine compartment of the liver. Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 280:910-923.
- Schmitt-Graff A, Kruger S, Bochard F, Gabbiani G, Denk H. 1991. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am. J. Pathol. 138:1233-1242.
- Senoo H, Mezaki Y, Fujiwara M. 2017. The stellate cell system (vitamin A-storing cell system). Anat. Sci. Int. 92:387-455. https://doi.org/10.1007/s12565-017-0395-9
- Shang L, Hosseini M, Liu X, Kisseleva T, Brenner DA. 2018. Human hepatic stellate cell isolation and characterization. J. Gastroenterol. 53:6-17. https://doi.org/10.1007/s00535-017-1404-4
- Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ. 2003. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37:87-95. https://doi.org/10.1053/jhep.2003.50002
- Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T. 2012. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 142:152-164.e10. https://doi.org/10.1053/j.gastro.2011.09.049
- Thoen LF, Guimarães EL, Dolle L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA. 2011. A role for autophagy during hepatic stellate cell activation. J. Hepatol. 55:1353-1360. https://doi.org/10.1016/j.jhep.2011.07.010
- Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Okada Y, Kurihara C, Irie R, Yokoyama H, Shimamura K, Usui S, Ebinuma H, Saito H, Watanabe C, Komoto S, Kawaguchi A, Nagao S, Sugiyama K, Hokari R, Kanai T, Miura S, Hibi T. 2014. Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 59:154-169. https://doi.org/10.1002/hep.26604
- Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J. 2000. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am. J. Pathol. 156:1235-1243. https://doi.org/10.1016/S0002-9440(10)64994-2
- Tsuchida T, Friedman SL. 2017. Mechanisms of hepatic stellate cell activation. Nat. Rev. Gastroenterol. Hepatol. 14:397-411. https://doi.org/10.1038/nrgastro.2017.38
- van Til NP, Markusic DM, van der Rijt R, Kunne C, Hiralall JK, Vreeling H, Frederiks WM, Oude-Elferink RP, Seppen J. 2005. Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes. Mol. Ther. 11:26-34. https://doi.org/10.1016/j.ymthe.2004.09.012
- Vaughn BP, Robson SC, Longhi MS. 2014. Purinergic signaling in liver disease. Dig. Dis. 32:516-524. https://doi.org/10.1159/000360498
- Wang H and Yin S. 2015. Natural killer T cells in liver injury, inflammation and cancer. Expert Rev. Gastroenterol. Hepatol. 9:1077-1085. https://doi.org/10.1586/17474124.2015.1056738
- Weiskirchen R and Tacke. 2014. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg. Nutr. 3:344-363. https://doi.org/10.3978/j.issn.2304-3881.2014.11.03
- Wiegard C, Frenzel C, Herkel J, Kallen KJ, Schmitt E, Lohse AW. 2005. Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells. Hepatology 42:193-199. https://doi.org/10.1002/hep.20756
- Yokoi Y, Namihisa T, Kuroda H, Komatsu I, Miyazaki A, Watanabe S, Usui K. 1984. Immunocytochemical detection of desmin in fat-storing cells (Ito cells). Hepatology 4:709-714. https://doi.org/10.1002/hep.1840040425