Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Persicaria senticosa Ameliorates Imiquimod-induced Psoriasis-like Skin Lesions in Mice via Suppression of IL-6/STAT3 Expression and Proliferation of Keratinocytes

  • Received : 2019.10.17
  • Accepted : 2019.12.13
  • Published : 2020.06.30
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Abstract

Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% - 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques on the skin with typical long-lasting red, itchy, and scaly lesions. In this study, we aimed to elucidate the anti-psoriatic effect of the methanolic extract of Persicaria senticosa (PS), a bioactive edible plant extract used in traditional medicine, using a mouse model of imiquimod (IMQ)-induced psoriasis. The daily topical application of IMQ could induce human psoriasis-like lesion. The extract ameliorated IMQ-induced psoriasis. Furthermore, hematoxylin and eosin staining and the Psoriasis Area and Severity Index (PASI) scores indicated that topical application of PS led to an improvement in erythema, scaling, and thickness scores of the mouse dorsal skin and a considerable decrease in the epidermal thickness of the ear and dorsal skin in the IMQ-induced psoriatic mouse model. We also studied the effect of PS on the proliferation of keratinocytes using HaCaT cells. The extract inhibited cell proliferation and IL-6 and pSTAT3 expression induced by M5 cocktail (comprising interleukin [IL]-1α, IL-17A, IL-22, oncostatin M, and tumor necrosis factor-α) in HaCaT cells. Thus, PS might serve as a potential therapeutic agent for the treatment of psoriasis.

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References

  1. Nograles, K. E.; Davidovici, B.; Krueger, J. G. Semin. Cutan. Med. Surg. 2010, 29, 3-9. https://doi.org/10.1016/j.sder.2010.03.001
  2. Zhou, Q.; Mrowietz, U.; Rostami-Yazdi, M. Free Radic. Biol. Med. 2009, 47, 891-905. https://doi.org/10.1016/j.freeradbiomed.2009.06.033
  3. Nestle, F. O.; Kaplan, D. H.; Barker, J. N. Engl. J. Med. 2009, 361, 496-509. https://doi.org/10.1056/NEJMra0804595
  4. Langley, R. G. B.; Krueger, G. G.; Griffiths, C. E. M. Ann. Rheum. Dis. 2005, 64, ii18- ii 23.
  5. van Vollenhoven, R. F. Ann. Rheum. Dis. 2007, 66, 849-851. https://doi.org/10.1136/ard.2007.069872
  6. Gniadecki, R.; Bang, B.; Bryld, L. E.; Iversen, L.; Lasthein, S.; Skov, L. Br. J. Dermatol. 2015, 172, 244-252. https://doi.org/10.1111/bjd.13343
  7. Gottlieb, A. B.; Armstrong, A. W. J. Rheumatol. 2013, 40, 1428-1433. https://doi.org/10.3899/jrheum.130456
  8. Kastelan, M.; Prpic -Massari, L.; Brajac, I. Acta Dermatovenerol. Croat. 2009, 17, 182-186.
  9. Park, B.; Jo, K.; Lee, T. G.; Hyun, S. W.; Kim, J. S.; Kim, C. S. Nutrients 2019, 11, 2792-2809. https://doi.org/10.3390/nu11112792
  10. Li, Q.; Fu, X.; Ge, X.; Tao, F.; Huang, P.; Ge, M.; Jin, H. Front. Oncol. 2019, 9, 578-593. https://doi.org/10.3389/fonc.2019.00578
  11. van der Fits, L.; Mourits, S.; Voerman, J. S. A.; Kant, M.; Boon, L.; Laman, J. D.; Cornelissen, F.; Mus, A. M.; Florencia, E.; Prens, E. P.; Lubberts, E. J. Immunol. 2009, 182, 5836-5845. https://doi.org/10.4049/jimmunol.0802999
  12. Nadeem, A.; Al-Harbi, N. O.; Al-Harbi, M. M.; El-Sherbeeny, A. M.; Ahmad, S. F.; Siddiqui, N.; Ansari, M. A.; Zoheir, K. M. A.; Attia, S. M.; Al-Hosaini, K. A.; Al-Sharary, S. D. Pharmacol. Res. 2015, 99, 248-257. https://doi.org/10.1016/j.phrs.2015.06.001
  13. Ueyama, A.; Yamamoto, M.; Tsujii, K.; Furue, Y.; Imura, C.; Shichijo, M.; Yasui, K. J. Dermatol. 2014, 41, 135-143. https://doi.org/10.1111/1346-8138.12367
  14. Guilloteau, K.; Paris, I.; Pedretti, N.; Boniface, K.; Juchaux, F.; Huguier, V.; Guillet, G.; Bernard, F. X.; Lecron, J. C.; Morel, F. J. Immunol. 2010, 184, 5263-5270. https://doi.org/10.4049/jimmunol.0902464
  15. Sun, J.; Han, J.; Zhao, Y.; Zhu, Q.; Hu, J. Int. Immunopharmacol. 2012, 13, 170-174. https://doi.org/10.1016/j.intimp.2012.03.025
  16. Ronpirin, C.; Tencomnao, T. Genet. Mol. Res. 2012, 11, 412-420. https://doi.org/10.4238/2012.February.17.3
  17. Miyoshi, K.; Takaishi, M.; Nakajima, K.; Ikeda, M.; Kanda, T.; Tarutani, M.; Iiyama, T.; Asao, N.; DiGiovanni, J.; Sano, S. J. Invest. Dermatol. 2011, 131, 108-117. https://doi.org/10.1038/jid.2010.255
  18. Lowes, M. A.; Bowcock, A. M.; Krueger, J. G. Nature 2007, 445, 866-873. https://doi.org/10.1038/nature05663
  19. Alappatt, C.; Johnson, C. A.; Clay, K. L.; Travers, J. B. Arch. Dermatol. Res. 2000, 292, 256-259. https://doi.org/10.1007/s004030050483
  20. Grone, A. Vet. Immunol. Immunopathol. 2002, 88, 1-12. https://doi.org/10.1016/S0165-2427(02)00136-8
  21. Grossman, R. M.; Krueger, J.; Yourish, D.; Granelli-Piperno, A.; Murphy, D. P.; May, L. T.; Kupper, T. S.; Sehgal, P. B.; Gottlieb, A. B. Proc. Natl. Acad. Sci. U S A 1989, 86, 6367-6371. https://doi.org/10.1073/pnas.86.16.6367
  22. Kupper, T. S.; Min, K.; Sehgal, P.; Mizutani, H.; Birchall, N.; Ray, A.; May, L. Ann. N. Y. Acad. Sci. 1989, 557, 454-464. https://doi.org/10.1111/j.1749-6632.1989.tb24038.x
  23. Taniguchi, K.; Arima, K.; Masuoka, M.; Ohta, S.; Shiraishi, H.; Ontsuka, K.; Suzuki, S.; Inamitsu, M.; Yamamoto, K. I.; Simmons, O.; Toda, S.; Conway, S. J.; Hamasaki, Y.; Izuhara, K. J. Invest. Dermatol. 2014, 134, 1295-1304. https://doi.org/10.1038/jid.2013.500
  24. Wang, Y.; van Boxel-Dezaire, A. H. H.; Cheon, H.; Yang, J.; Stark, G. R. Proc. Natl. Acad. Sci. U S A 2013, 110, 16975-16980. https://doi.org/10.1073/pnas.1315862110
  25. Izumi-Nagai, K.; Nagai, N.; Ozawa, Y.; Mihara, M.; Ohsugi, Y.; Kurihara, T.; Koto, T.; Satofuka, S.; Inoue, M.; Tsubota, K.; Okano, H.; Oike, Y.; Ishida, S. Am. J. Pathol. 2007, 170, 2149-2158. https://doi.org/10.2353/ajpath.2007.061018
  26. Hirano, T.; Ishihara, K.; Hibi, M. Oncogene 2000, 19, 2548-2556. https://doi.org/10.1038/sj/onc/1203551
  27. Orecchia, V.; Regis, G.; Tassone, B.; Valenti, C.; Avalle, L.; Saoncella, S.; Calautti, E.; Poli, V. Exp. Dermatol. 2015, 24, 29-34. https://doi.org/10.1111/exd.12585
  28. Sano, S.; Chan, K. S.; Carbajal, S.; Clifford, J.; Peavey, M.; Kiguchi, K.; Itami, S.; Nickoloff, B. J.; DiGiovanni, J. Nat. Med. 2005, 11, 43-49. https://doi.org/10.1038/nm1162
  29. Kim, S. Y.; Won, D. H.; Park, S. N. Kor. J. Microbiol. Biotechnol. 2010, 38, 278-282.
  30. El-Hawary, S. A.; Sokkar, N. M.; Ali, Z. Y.; Yehia, M. M. J. Food Sci. 2011, 76, C1195-C1202. https://doi.org/10.1111/j.1750-3841.2011.02370.x
  31. Prakash Mishra, A.; Sharifi-Rad, M.; Shariati, M. A.; Mabkhot, Y. N.; Al-Showiman, S. S.; Rauf, A.; Salehi, B.; Zupunski, M.; Sharifi-Rad, M.; Gusain, P.; Sharifi-Rad, J.; Suleria, H. A. R.; Iriti, M. Cell. Mol. Biol. 2018, 64, 27-34. https://doi.org/10.14715/cmb/2018.64.8.5