Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

A rare case of bovine tuberculosis caused by Mycobacterium bovis in a domestic rabbit

  • Roh, Su Gwon (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Jang, Yun-Ho (Bacterial Disease Division, Animal and Plant Quarantine Agency) ;
  • Kim, Jongho (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Lee, Kyunghyun (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • So, Byungjae (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Choi, Eun-Jin (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency)
  • Received : 2019.12.12
  • Accepted : 2020.03.16
  • Published : 2020.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

A 12-month-old domestic rabbit died suddenly without specific clinical signs. Gross examination revealed irregular yellowish hepatic nodules with pus in the submandibular muscles, lungs, uterus, and small intestines. Histopathological examination of the liver showed granulomatous inflammation with acid-fast-positive bacteria. Mycobacterium bovis SB1040 was identified by polymerase chain reaction and spoligotyping, and Pasteurella multocida was isolated from the multiple lesions. This report demonstrates the pathological features of rare bovine tuberculosis (bTB) in a domestic rabbit, the first case in the Republic of Korea. To ensure public safety, we recommend routine monitoring of rabbits to control the incidence of bTB.

Keywords

References

  1. Delahay RJ, De Leeuw AN, Barlow AM, Clifton-hadley RS, Cheeseman CL. The status of Mycobacterium bovis infection in UK wild mammals: a review. Vet J 2002;164:90-105. https://doi.org/10.1053/tvjl.2001.0667
  2. Lee H, Kim JM, Jang Y, Lee K, Baek K, Lee B, Kim HY, Lee MH, Ryoo S, Bae YC, Choi EJ, So B. Bovine tuberculosis in an Asian small-clawed otter (Aonyx cinerea) in the Republic of Korea. J Vet Diagn Invest 2015;27:651-655. https://doi.org/10.1177/1040638715600198
  3. Verna AK, Tiwari R, Chakraborty S, Neha, Saminathan M, Dhama K, Singh SV. Insights into bovine tuberculosis (bTB), various approaches for its diagnosis, control and its public health concerns: an update. Asian J Anim Vet Adv 2014;9:323-344. https://doi.org/10.3923/ajava.2014.323.344
  4. Fitzgerald SD, Kaneene JB. Wildlife reservoirs of bovine tuberculosis worldwide: hosts, pathology, surveillance, and control. Vet Pathol 2013;50:488-499. https://doi.org/10.1177/0300985812467472
  5. Jeong J, Lee K, Choi EJ, Kim HY, Sohn JH, So B, Jung JY. Meningoencephalitis and pneumonia caused by Pasteurella multocida in rabbits. Korean J Vet Res 2018;58:61-64. https://doi.org/10.14405/kjvr.2018.58.1.61
  6. Taylor GM, Worth DR, Palmer S, Jahans K, Hewinson RG. Rapid detection of Mycobacterium bovis DNA in cattle lymph nodes with visible lesions using PCR. BMC Vet Res 2007;3:12. https://doi.org/10.1186/1746-6148-3-12
  7. Yeboah-Manu D, Yates MD, Wilson SM. Application of a simple multiplex PCR to aid in routine work of the mycobacterium reference laboratory. J Clin Microbiol 2001;39:4166-4168. https://doi.org/10.1128/JCM.39.11.4166-4168.2001
  8. Jang Y, Ryoo S, Lee H, Kim N, Lee H, Park SY, Song WS, Kim JT, Lee HS, Kim JM. Isolation of Mycobacterium bovis from free-ranging wildlife in South Korea. J Wildl Dis 2017;53:181-185. https://doi.org/10.7589/2015-11-295
  9. Kim J, Kim JW, O h SI, So B , Kim WI, Kim HY. Characterisation of Pasteurella multocida isolates from pigs with pneumonia in Korea. BMC Vet Res 2019;15:119. https://doi.org/10.1186/s12917-019-1861-5
  10. Townsend KM, Frost AJ, Lee CW, Papadimitriou JM, Dawkins HJ. Development of PCR assays for species- and type-specific identification of Pasteurella multocida isolates. J Clin Microbiol 1998;36:1096-1100. https://doi.org/10.1128/JCM.36.4.1096-1100.1998
  11. Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, Kuijper S, Bunschoten A, Molhuizen H, Shaw R, Goyal M, van Embden J. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol 1997;35:907-914. https://doi.org/10.1128/jcm.35.4.907-914.1997
  12. Smith NH, Upton P. Naming spoligotype patterns for the RD9-deleted lineage of the Mycobacterium tuberculosis complex; www.Mbovis.org. Infect Genet Evol 2012;12:873-876. https://doi.org/10.1016/j.meegid.2011.08.002
  13. Barthold SW, Griffey SM, Percy DH. Rabbit. In: Barthold SW, Griffey SM, Percy DH (eds.). Pathology of laboratory rodents and rabbits. 4th ed. pp. 282. Wiley-Blackwell, New Jersey, 2016.
  14. Calvete C, Estrada R, Villafuerte R, Osacar JJ, Lucientes J. Epidemiology of viral haemorrhagic disease and myxomatosis in a free-living population of wild rabbits. Vet Rec 2002;150:776-782. https://doi.org/10.1136/vr.150.25.776
  15. Allen GM. Other animals as sources of TB [tuberculosis] infection. In: Jackson R (ed.). Proceedings of a Symposium on Tuberculosis. New Zealand Veterinary Association; Foundation for Continuing Education, Palmerston North, pp. 197-201, 1991.