Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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Fabrication and Characterization of Gastrodia elata-loaded Particles for Increased Moisture Stability

수분 안정성 향상을 위한 천마 추출물 함유 분말의 제조 및 평가

  • Jung, Jae Hwan (Department of Pharmaceutical Engineering, Dankook University) ;
  • Jin, Sung Giu (Department of Pharmaceutical Engineering, Dankook University)
  • 정재환 (단국대학교 제약공학과) ;
  • 진성규 (단국대학교 제약공학과)
  • Received : 2020.06.05
  • Accepted : 2020.06.16
  • Published : 2020.06.28
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Abstract

To develop Gastrodia elata (GE)-loaded particles for herbal extract dosage forms, various GE-loaded particles containing dextrin, isomalt, maltodextrin, and silicon dioxide as solidifying carriers in the GE water extract are prepared using the spray drying method. Their physical properties are evaluated using the repose angle, Hausner ratio, Carr's index, weight increase rate at 40℃/75% RH condition, and scanning electron microscopy (SEM). Particles made of dextrin improve the fluidity, compressibility, and water stability. In addition, 2% silicon dioxide increases the fluidity and moisture stability. The best flowability and compressibility of GE-loaded particles are observed with TP, dextrin, and silicon dioxide amounts in the ratio of 6/4/0.2 (34.29 ± 2.86°, 1.48 ± 0.03, and 38.29 ± 2.39%, repose angle, Hausner Ratio, and Carr's index, respectively) and moisture stability with a 2% weight increase rate for 14 h at 40℃/75% RH condition. Therefore, our results suggest that the particles prepared by the spray drying method with dextrin and 2% silicon dioxide can be used as powerful particles to improve the flowability, compressibility, and moisture stability of GE.

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References

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