Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases

  • Dasheng Li (Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital)) ;
  • Dawei Wang (Institute of Advanced Research) ;
  • Jianping Dong (Department of Infection, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital)) ;
  • Nana Wang (Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital)) ;
  • He Huang (Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital)) ;
  • Haiwang Xu (Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital)) ;
  • Chen Xia (Institute of Advanced Research)
  • Received : 2020.02.19
  • Accepted : 2020.02.25
  • Published : 2020.04.01
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Abstract

The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.

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References

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