Journal of the Korean Orthopaedic Association (대한정형외과학회지)

Korean Orthopaedic Association (대한정형외과학회)
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Effect of Postoperative Parathyroid Hormone Administration on Osteoporotic Intertrochanteric Fractures of Females

골다공증성 대퇴 전자간 골절 여성 환자에서 수술 후 부갑상선 호르몬제제의 투여효과

  • Oh, Hyun Cheol (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital) ;
  • Yoo, Ju Hyung (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital) ;
  • Ha, Joong Won (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital) ;
  • Park, Yung (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital) ;
  • Park, Sang Hoon (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital) ;
  • Yoon, Han Kook (Department of Orthopedic Surgery, National Health Insurance Service Ilsan Hospital)
  • 오현철 (국민건강보험 일산병원 정형외과) ;
  • 유주형 (국민건강보험 일산병원 정형외과) ;
  • 하중원 (국민건강보험 일산병원 정형외과) ;
  • 박융 (국민건강보험 일산병원 정형외과) ;
  • 박상훈 (국민건강보험 일산병원 정형외과) ;
  • 윤한국 (국민건강보험 일산병원 정형외과)
  • Received : 2019.03.28
  • Accepted : 2019.09.30
  • Published : 2020.06.30
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Abstract

Purpose: This study examined the effects of the postoperative administration of parathyroid hormone (PTH) on fracture healing in intertrochanteric fractures accompanied by osteoporosis in elderly females. Materials and Methods: Female patients aged 65 years and more who underwent surgery after a diagnosis of intertrochanteric fractures and osteoporosis during the period from July 2013 to December 2017 were included as subjects. The subjects were divided into two groups: PTH-treated group and non-PTH-treated group. The formation time of the first callus, timing of the bridging callus, and time of bony union for both groups were evaluated. Results: In the PTH-treated group, the mean time of the first callus formation, average time of bridging callus, and the average time of bony union were 32, 58, 83 days, respectively, which were significantly shorter than that of the untreated group. Conclusion: PTH, a treatment for osteoporosis, promotes callus formation and the healing process. Therefore it will be helpful in intertrochanteric fractures accompanied by osteoporosis in elderly females.

목적: 고령 여성에서 대퇴부에 발생한 골다공증과 동반된 전자간 골절에서 수술 후에 부갑상선 호르몬 제제 투여 후 골절 치유에 대한 영향을 알아보고자 하였다. 대상 및 방법: 2013년 7월부터 2017년 12월까지 대퇴부 전자간 골절 및 골다공증을 진단 받은 후 수술을 시행한 65세 이상의 여자 환자에서 부갑상선 호르몬 제제를 투여한 군과 투여하지 않은 군을 대상으로 최초 가골의 형성 시기, 가골교로의 진행 시기 및 골유합 진행 시기를 조사하였다. 결과: 부갑상선 호르몬 투여군에서 최초 가골의 형성은 평균 32일, 가골교로의 진행은 평균 58일, 골유합이 된 시기는 평균 83일로 투약을 하지 않은 군에 비하여 통계적으로 의미 있게 기간이 단축된 소견을 보였다. 결론: 골다공증 치료제인 부갑상선 호르몬 제제는 고령의 여성에서 골다공증이 동반된 전자간 골절에서 가골의 형성 및 치유 과정을 촉진시킨다. 따라서 수술 후 이의 투여가 도움이 될 거라 생각된다.

Keywords

Acknowledgement

이 연구는 국민건강보험 일산병원의 연구비 지원으로 이루어졌음 (NHIMC2018CR014).

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