DOI QR코드

DOI QR Code

Multiple nonmelanocytic skin cancers in multiple regions

  • Han, Song Hyun (Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine) ;
  • Kim, Soon Heum (Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine) ;
  • Kim, Cheol Keun (Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine) ;
  • Jo, Dong In (Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine)
  • 투고 : 2020.02.24
  • 심사 : 2020.04.27
  • 발행 : 2020.06.20

초록

The most common forms of nonmelanocytic skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The growing incidence of skin cancer in the Republic of Korea has sparked increasing scientific interest in these types of tumors. In the case described herein, multiple NMSCs occurred asynchronously in various areas of the body in a single patient. A 67-year-old man presented with an ulcerative lesion on the right retro-auricle and multiple keratinized masses on the back and face. The right retro-auricular lesion was diagnosed as BCC, and the keratinized masses on the patient's back and face were diagnosed as SCC. He subsequently presented with numerous pigmented skin lesions on the forehead, temple, pre-auricle, neck, right forearm, right hand, and both thighs. One lesion on the neck was diagnosed as BCC, and five lesions on the right hand and forearm were diagnosed as SCC. The patient was also diagnosed with supraglottic SCC and external auditory canal SCC. An otolaryngologist performed radical excision of the primary SCC. Suspected skin cancer lesions observed on the face and both ears were diagnosed as SCC. Patients with multiple NMSCs are at an elevated risk for additional skin cancers, making periodic follow-up important; furthermore, all suspicious lesions should be biopsied.

키워드

참고문헌

  1. Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol 2015;151:1081-6. https://doi.org/10.1001/jamadermatol.2015.1187
  2. Motley R, Kersey P, Lawrence C; British Association of Dermatologists; British Association of Plastic Surgeons; Royal College of Radiologists, Faculty of Clinical Oncology. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 2002;146:18-25. https://doi.org/10.1046/j.0007-0963.2001.04615.x
  3. Veness MJ. High-risk cutaneous squamous cell carcinoma of the head and neck. J Biomed Biotechnol 2007;2007:80572. https://doi.org/10.1155/2007/80572
  4. Nakayama M, Tabuchi K, Nakamura Y, Hara A. Basal cell carcinoma of the head and neck. J Skin Cancer 2011;2011:496910.
  5. Chockalingam R, Downing C, Tyring SK. Cutaneous squamous cell carcinomas in organ transplant recipients. J Clin Med 2015;4:1229-39. https://doi.org/10.3390/jcm4061229
  6. Chuang TY, Popescu NA, Su WP, Chute CG. Squamous cell carcinoma: a population-based incidence study in Rochester, Minn. Arch Dermatol 1990;126:185-8. https://doi.org/10.1001/archderm.1990.01670260055010
  7. Kim DH, Ko HS, Jun YJ. Nonsyndromic multiple basal cell carcinomas. Arch Craniofac Surg 2017;18:191-6. https://doi.org/10.7181/acfs.2017.18.3.191
  8. Lorimer P, Milas Z. Cutaneous manifestations associated with malignancy of the head and neck. Semin Oncol 2016;43:353-8. https://doi.org/10.1053/j.seminoncol.2016.02.023
  9. Burton KA, Ashack KA, Khachemoune A. Cutaneous squamous cell carcinoma: a review of high-risk and metastatic disease. Am J Clin Dermatol 2016;17:491-508. https://doi.org/10.1007/s40257-016-0207-3
  10. Czarnecki D, Sutton T, Czarnecki C, Culjak G. A 10-year prospective study of patients with skin cancer. J Cutan Med Surg 2002;6:427-9. https://doi.org/10.1177/120347540200600503
  11. Levine DE, Karia PS, Schmults CD. Outcomes of patients with multiple cutaneous squamous cell carcinomas: a 10-year single-institution cohort study. JAMA Dermatol 2015;151:1220-5. https://doi.org/10.1001/jamadermatol.2015.1702
  12. Marcil I, Stern RS. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000;136:1524-30.
  13. Izuhara K, Yamaguchi Y, Ohta S, Nunomura S, Nanri Y, Azuma Y, et al. Squamous cell carcinoma antigen 2 (SCCA2, SERPINB4):an emerging biomarker for skin inflammatory diseases. Int J Mol Sci 2018;19:1102. https://doi.org/10.3390/ijms19041102
  14. Peller M, Katalinic A, Wollenberg B, Teudt IU, Meyer JE. Epidemiology of laryngeal carcinoma in Germany, 1998-2011. Eur Arch Otorhinolaryngol 2016;273:1481-7. https://doi.org/10.1007/s00405-016-3922-8
  15. Calhoun KH, Fulmer P, Weiss R, Hokanson JA. Distant metastases from head and neck squamous cell carcinomas. Laryngoscope 1994;104:1199-205.
  16. Trehan R, Pandey AK, Khosla D, Dimri K, Punia RS. Apropos of a case of cutaneous metastasis from laryngeal cancer with review of literature. J Cancer Res Ther 2015;11:655.
  17. Saini R, Sharma N, Pandey K, Puri KJ. Multiple skin cancers in a single patient: multiple pigmented Bowen's disease, giant basal cell carcinoma, squamous cell carcinoma. J Cancer Res Ther 2015;11:669.
  18. Moy RL. Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000;42(1 Pt 2):8-10. https://doi.org/10.1067/mjd.2000.103343

피인용 문헌

  1. Basal cell nevus syndrome with excessive basal cell carcinomas vol.22, pp.2, 2020, https://doi.org/10.7181/acfs.2021.00136