Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Rapidly growing giant pilomatricoma in the right parotid region of a pregnant woman

  • Koh, In Suk (Department of Plastic and Reconstructive Surgery, Inje University Busan Paik Hospital, Inje University School of Medicine) ;
  • Cho, Hwa Jin (Department of Pathology, Inje University Busan Paik Hospital) ;
  • Kim, Jin Woo (Department of Plastic and Reconstructive Surgery, Inje University Busan Paik Hospital, Inje University School of Medicine)
  • Received : 2019.10.31
  • Accepted : 2020.03.20
  • Published : 2020.06.20
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Abstract

Pilomatricoma is a benign tumor arising from the primitive basal cells of the epidermis that differentiate into hair matrix cells. Mutations in the CTNNB1 gene, which encodes β-catenin (a protein involved in hair growth), play an etiological role in the development of pilomatricoma. A 34-year-old woman presenting with a mass in the right parotid region underwent an excisional biopsy. The mass was conclusively diagnosed as pilomatricoma. During pregnancy, the mass grew from 1 cm to 5 cm in diameter and was accompanied by pain and tenderness. The growth may have been facilitated by the increased production of estrogen and progesterone, which bind to receptors located in the outer root sheath cells of the hair follicles. No recurrence was observed during 6 months of follow-up.

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References

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