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Current Understanding on the Metabolism of Neutrophils

  • Jae-Han Jeon (Department of Internal Medicine, School of Medicine, Kyungpook National University) ;
  • Chang-Won, Hong (Kyungpook National University Hospital, Bio-Medical Research Institute) ;
  • Eun Young Kim (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University) ;
  • Jae Man Lee (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University)
  • Received : 2020.10.27
  • Accepted : 2020.12.13
  • Published : 2020.12.31
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Abstract

Neutrophils are innate immune cells that constitute the first line of defense against invading pathogens. Due to this characteristic, they are exposed to diverse immunological environments wherein sources for nutrients are often limited. Recent advances in the field of immunometabolism revealed that neutrophils utilize diverse metabolic pathways in response to immunological challenges. In particular, neutrophils adopt specific metabolic pathways for modulating their effector functions in contrast to other immune cells, which undergo metabolic reprogramming to ensure differentiation into distinct cell subtypes. Therefore, neutrophils utilize different metabolic pathways not only to fulfill their energy requirements, but also to support specialized effector functions, such as neutrophil extracellular trap formation, ROS generation, chemotaxis, and degranulation. In this review, we discuss the basic metabolic pathways used by neutrophils and how these metabolic alterations play a critical role in their effector functions.

Keywords

Acknowledgement

This work was supported by the Biomedical Research Institute Grant, Kyungpook National University Hospital (2018) and by a grant of the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant No. HI15C0001).

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