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The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches

  • Received : 2020.03.02
  • Accepted : 2020.05.09
  • Published : 2020.06.30
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Abstract

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.

Keywords

Acknowledgement

We thank Sang-Hoon Kim and Aryeong Choi for their useful and constructive suggestions on this review. This work was supported by the National Research Foundation of Korea (NRF) funded by Ministry of Education, Science and Technology (NRF-2019R1A6A1A03031807).

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