Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Antioxidant and Anti-inflammatory Activities of Tetragonia tetragonoides Water Extract

번행초 추출물의 항산화 및 항염증 효과

  • Kong, Ji Hyun (School of Korean Medicine, Pusan National University) ;
  • Lee, Ki Yeon (School of Korean Medicine, Pusan National University) ;
  • Rho, Dae Hyun (School of Korean Medicine, Pusan National University) ;
  • Lee, Jang-Cheon (School of Korean Medicine, Pusan National University) ;
  • An, Won Gun (School of Korean Medicine, Pusan National University) ;
  • Lee, Boo-Kyun (School of Korean Medicine, Pusan National University)
  • 공지현 (부산대학교 한의학전문대학원) ;
  • 이기연 (부산대학교 한의학전문대학원) ;
  • 노대현 (부산대학교 한의학전문대학원) ;
  • 이장천 (부산대학교 한의학전문대학원) ;
  • 안원근 (부산대학교 한의학전문대학원) ;
  • 이부균 (부산대학교 한의학전문대학원)
  • Received : 2020.04.27
  • Accepted : 2020.05.25
  • Published : 2020.05.31
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Abstract

Objectives : Tetragonia tetragonioides is one of the traditional herbal medicines that can be used to protect the stomach and treat cancer. However, its mechanism of overcoming gastrointestinal disorders is unclear. In this study, we investigated antioxidant and anti-inflammatory effects of Tetragonia tetragonioides Water Extract (TTWE) on RAW264.7 cells. Methods : The cell viability by TTWE was measured by using MTT assay. The free radical scavenging ability and cytokine production were analyzed by using ELISA Kit. SPSS version 25 was used for statistical analysis. Results : According to the results of this study, the cell viability measurement of TTWE significantly affected the cell viability. The radical scavenging ability of TTWE showed the highest effect compared to the positive control group when the concentration was 3.1-12.5 ㎍/ml, and significantly inhibited NO production induced by LPS. In addition, the inhibitory effect of TTWE on the production of IL-6 and TNF-α induced by LPS was significant at both TTWE concentrations of 12.5 ㎍/ml [p <0.01 (IL-6), p <0.05 (TNF-α)]. Conclusion : In conclusion, it is suggested that the antioxidant function of Tetragonia tetragonioides Water Extract could be used to prevent and treat inflammatory diseases.

Keywords

References

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