The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Review of Randomized Controlled Trials of Oriental Medicine for Recurrent Vulvovaginal Candidiasis

재발성 칸디다성 외음질염의 한약치료 효과에 관한 무작위 대조 연구 문헌고찰

  • Chae, Min-Soo (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Seung-Hyeok (Dept. of Korean Medicine Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Hwang, Deok-Sang (Dept. of Korean Medicine Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Jin-Moo (Dept. of Korean Medicine Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Chang-Hoon (Dept. of Korean Medicine Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Jang, Jun-Bock (Dept. of Korean Medicine Gynecology, College of Korean Medicine, Kyung Hee University)
  • 채민수 (경희대학교 대학원 임상한의학과) ;
  • 박승혁 (경희대학교 한의과대학 한방부인과교실) ;
  • 황덕상 (경희대학교 한의과대학 한방부인과교실) ;
  • 이진무 (경희대학교 한의과대학 한방부인과교실) ;
  • 이창훈 (경희대학교 한의과대학 한방부인과교실) ;
  • 장준복 (경희대학교 한의과대학 한방부인과교실)
  • Received : 2020.01.08
  • Accepted : 2020.05.29
  • Published : 2020.05.29
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Abstract

Objectives: The purpose of this study is to review and evaluate the effectiveness of oriental medicine per oral for recurrent vulvovaginal candidiasis (RVVC). Methods: We searched articles from Korean journal databases including Journal of Korean Obstetrics and Gynecology, Korean studies Information Service Studies, and Chinese National Knowledge Infrastructure, Cochrane Library, PubMed. Searched keywords were "재발성 칸디다성 외음질염", "recurrent vulvovaginal candidiasis", "㚆发性外阴阴道假丝酵母菌病", "中藥". Results: 10 randomized controlled trials with 700 patients were identified and reviewed. 8 studies compared combination of oriental medicine and anti-fungal agent with anti-fungal agent, and 6 of them reported that treatment group (TG) showed statistically higher total effective rate or cure rate and lower recurrence rate. One study compared oriental medicine and anti-fungal agent and TG showed statistically higher total effective rate and lower recurrence rate after 1 month. One study compared combination of oriental medicine and lacto bacillus capsule with lacto bacillus capsule, and TG showed statistically higher total effective rate and lower positive fungul test rate after 6 months. No severe adverse response was reported. Conclusions: Our review found that oriental medicine per oral is effective for alleviating symptoms, lowering recurrence rate and positive fungal test in RVVC patients. We recommend standardized randomized controlled trial guideline should be made to obtain stronger evidence and well designed trials with larger sample sizes are needed.

Keywords

References

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