DOI QR코드

DOI QR Code

Curcuma longa: A treasure of medicinal properties

  • Received : 2019.11.02
  • Accepted : 2020.03.05
  • Published : 2020.05.29

Abstract

Nature is full of precious treasure to cure us from various disorders. One of them is Curcuma longa belonging to Zingiberaceae family, present with outstanding therapeutic value and used since time immemorial. Part used from the plant is rhizome native to India (south east continent) which is the world's largest producer, consumer and exporter of turmeric. The active principle called curcumin or diferuloylmethane is a yellow pigment that exhibits numerous activities and wide spectrum of biological actions which include anti-inflammatory, hepatoprotective, anti-cancerous, anti-fungal, neuroprotective activities and many more. This paper focuses on the comparative evaluation of medicinal properties of Curcuma longa as mentioned in Unani classical literature with its modern scientific researches.

Keywords

References

  1. Alam G, Singh MP and Singh A. Wound healing potential of some medicinal plants. Journal of Pharmaceutical Sciences Review and Research. 2011; 1:9:136-145.
  2. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: An "old-age" disease with an "ageold" solution. Cancer Lett. 2008:267:133-164. https://doi.org/10.1016/j.canlet.2008.03.025
  3. Anonymous. Indian Medicinal Plants. (Chennai: Orirnt Longmen limited), 2004, pp 259.
  4. Anonymous. The Useful Plants of India. (Calcutta: CSIR), 1986, pp 151-152.
  5. Aronson JK. Meyler's Side effect of Medicinal Herb. (Elsevier Science), 2009; 233-234.
  6. Asolkar LV, Kakkar KK and Chakkre OJ. Second Supplement to Glossary of Indian Medicinal Plants with Active Prociples (New Delhi: CSIR), 1992, pp. 246-247.
  7. Bentley R and Trimen H. Medicinal Plants. (New Delhi: Asiatic Publishing House), vol. 4, 2009, 269.
  8. CCRUM. Medicinal Plants in Folklores of Southern India. (New Delhi: CCRUM), 2001, pp 76.
  9. CCRUM. Unani Medicinal Plants of Siddhart nagarForest Divivsion UP. (Uttar Pardesh: CCRUM), 2009, pp 68.
  10. Cerny D, Lekic N, Vanova K, Muchova L, Horinek A, Kmonickova E, Zidek Z, Kamenikova L, Farghali H. Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/ CO antioxidant system. Fitoterapia. 2011; 5:82:786-791. https://doi.org/10.1016/j.fitote.2011.04.003
  11. Chainani WN. Safety and anti-inflammatory activity of curcum: a component of tumeric (Curcuma longa). J. Altern. Complement Med. 2003;1:9:161-168. https://doi.org/10.1089/107555303321223035
  12. Cheng TS, Chen WC, Lin YY, Tsai CH, Liao CI, Shyu HY, Ko CJ, Tzeng SF, Huang CY, Yang PC, Hsiao PW and Lee MS. Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis. Cancer Prev. Res. 2013;5:6:495-505. https://doi.org/10.1158/1940-6207.CAPR-12-0293-T
  13. Chopra RN, Nayar SL and Chopra IC. Glossary of Indain Plants. (New Delhi: CSIR), 1956, pp 84-85.
  14. Das K. Turmeric (Curcuma longa) oils. In: Preedy, V.R. (Ed.), Essential Oils in Food Preservation, Fla-vor and Safety. (San Diego: Academic Press), 2016, pp 835-841.
  15. Devassy J, Nwachukwu I and Jones P. Curcumin and cancer: Barriers to obtaining a health claim. Nutr. Rev. 2015;3:73:155-165. https://doi.org/10.1093/nutrit/nuu064
  16. Evans WC. Trease and Evans' Pharmacognosy. (A Divisionof Reed Elsevier India Pvt. Limited), 2002, pp 280.
  17. Fan H, Tian W and Ma X. Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid syn-thase. Target Oncol. 2014; 3:9:279-286. https://doi.org/10.1007/s11523-013-0286-5
  18. Gayathri D, Sathish S and Sakthi R. Wound Healing Activity of Curcuma longa with Oleum olivae. Journal of Academia and Industrial Research (JAIR). 2015; 10:3.
  19. Ghani Najmul. Khazeenat-ul-Advia. (Lahore: Daimond Publisher), 1912; 3(3):1049-1051.
  20. Government of India. The Ayurvedic Pharmacopoeia of India (Delhi: Ministry of Helath & Welfare), 2001; 1(1):45-46.
  21. Issuriya A, Kumarnsit E, Wattanapiromsakul C, Vongvatcharanon U. Histological studies of neuroprotective effects of Curcuma longa Linn. on neuronal loss induced by dexamethasone treatment in the rat hippocampus. Acta Histochem. 2014; 8(116):1443-1453. https://doi.org/10.1016/j.acthis.2014.09.009
  22. Kabiruddin Mohd. Makhzanul-ul -Mufridat. (New Delhi: Idara Kitab-u-Shifa), 2007, pp 314-315.
  23. Kanjana S, Piya K and Kanitta J, Jiraungkoorskul W. Antithrombotic activity of turmeric (Curcuma longa): A review. Agricultural research communication centre. 2016; 50: 101-106.
  24. Khan MA. Muheet Azam trans. (Delhi: CCRUM), 2013; 2:757-758.
  25. Kim HJ, Yoo HW, Kim JC, Park CS, Choi MS, Kim MJ, Choi HS, Jung SM, Kim YS, Yoon SW, Ahn JK. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. Journal of ethonopharmacology, 2009; 124(2);189-96 https://doi.org/10.1016/j.jep.2009.04.046
  26. Kim K, Kim KH, Kim HY, Cho HK, Sakamoto N, Cheong JH. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Lett. 2010; 4:584:707-712. https://doi.org/10.1016/j.febslet.2009.12.019
  27. Kim M K, Choi GJ and Lee HS. Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse. J Agric. Food Chem. 2003; 51(6):1578-1581. https://doi.org/10.1021/jf0210369
  28. Kim Y, You Y, Yoon HG, Lee YH, Kim K, Lee J, Kim MS, Kim JC, Jun W. Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chem. 2014; 151:14-153.
  29. Kim YJ, You YH and Jun WJ. Hepatoprotective activity of fermented Curcuma longa L.on galactosamine-intoxicated rats. Korean Soc. Food Sci. Nut. 2012; 41:790-795. https://doi.org/10.3746/jkfn.2012.41.6.790
  30. Kritikar KR, Basu BD, Blatter E, Caius JF and Mhaskar KS. Indian Medicnal Plants. (Dehradun: Internatinal Book Distriibutor), 1996.
  31. Kumar A, Dogra S and Prakash A. Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav. Brain Res. 2009; 2:205:384-390. https://doi.org/10.1016/j.bbr.2009.07.012
  32. Kumar N and Kumar S. Ethnopharmacological properties of Curcuma longa: a review. International Journal of Pharmaceutical Sciences and Research. 2013; 1:4:103-112.
  33. Lal J. Turmeric curcumin and our life:a review. Bull.Env.Pharmacol Life Science. 2012; 1:11-17.
  34. Lawhavinit OA, Kongkathip N and Kongkathip B. Antimicrobial activity of curcuminoids from Cur-cuma longa L. on pathogenic bacteria of shrimp and chicken Kasetsart. J. Nat. Sci. 2010; 3:44:364-371.
  35. Lee HS. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Biores. Technol. 2006; 97:1372-1376. https://doi.org/10.1016/j.biortech.2005.07.006
  36. Lekshmi PC, Arimboor R, Nisha VM, Menon AN, Raghu KG. In vitro anti-diabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme. J. Food Sci. Technol. 2014; 2:52:3910-3917.
  37. Liu D and Chen Z. The effect of curcumin on breast cancer cells. J. Breast Cancer. 2013; 2:16:133-137. https://doi.org/10.4048/jbc.2013.16.2.133
  38. Lu WD, Qin Y, Yang C, Li L, Fu ZX. Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo. Clinic. 2013; 5:68:694-701. https://doi.org/10.6061/clinics/2013(05)18
  39. Manhas A, Khanna V, Prakash P, Goyal D, Malasoni R, Naqvi A, Dwivedi AK, Dikshit M, Jagavelu K. Curcuma oil reduces endothelial cell-mediated inflammation in postmyocardial ischemia reperfusion in rats. J. Cardiovasc. Pharmacol. 2014; 3:64:228-236. https://doi.org/10.1097/FJC.0000000000000110
  40. Mayanglambam A, Dangelmaier CA, Thomas D, Damodar Reddy C, Daniel JL, Kunapuli SP. Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCa2. Platelets. 2010; 21:211-220. https://doi.org/10.3109/09537100903528269
  41. Meesarapee B, Thampithak A, Jaisin Y, Sanvarinda P, Suksamrarn A, Tuchinda P, Morales NP, Sanvarinda Y. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytother. Res. 2014; 28(4): 611-616. https://doi.org/10.1002/ptr.5036
  42. Mirzabeigia P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadia MR. The effect of curcumin on some of traditional and nontraditional cardiovascular risk factors: A pilot randomized, double-blind, placebo-controlled trial. J. Pharm. Res. 2015; 14(2):479-486.
  43. Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Zandi K. A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed. Res. Int. 2014; Niamsa N and Sittiwet C. Antimicrobial activity of Curcuma longa aqueous extract. J. Pharmacol. Toxicol. 2009; 4: 4:173-177. https://doi.org/10.3923/jpt.2009.173.177
  44. Omosa LK, Midiwo JO and Kuete V. Curcuma longa Medicinal Spices and Vegetables from Africa. (Elsevier). 2017, pp 425-435.
  45. Parrotta JA. Healing Plants of Peninsular India (New York: CABI), 2001, pp 726-727.
  46. Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol.Adv. 2014; 32:1053-1064. https://doi.org/10.1016/j.biotechadv.2014.04.004
  47. Rai PK, Jaiswal D, Mehta S, Rai DK, Sharma B, Watal G. Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats. Indian J. Clin. Biochem. 2010; 25(2):175-181. https://doi.org/10.1007/s12291-010-0032-z
  48. Ravindran J, Subbaraju GV, Ramani MV, Sung B, Aggarwal BB. Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, antiproliferative and anti-inflammatory activities in vitro. Biochem. Pharmacol. 2010; 79(11):1658-1666. https://doi.org/10.1016/j.bcp.2010.01.033
  49. Salama SM, Abdulla MA, AlRashdi AS, Ismail S, Alkiyumi SS, Golbabapour S. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern. Med. 2013; 13:56. https://doi.org/10.1186/1472-6882-13-56
  50. Sambhav J, Rohit R, Raj UA, Garima M. Curcuma longa in the management of inflammatory diseases: a review. Int. Ayur. Med. J. 2014; 2(2):33-40.
  51. Shehzad A, Lee J, Huh TL, Lee YS. Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53. Mol. Cells. 2013; 6:35.
  52. Shivalingu BR, Vivek HK, Nafeesa Z, Priya BS, Swamy SN. Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species. J. Ethnopharmacol. 2015; 172:261-264. https://doi.org/10.1016/j.jep.2015.06.018
  53. Sun J, Zhao Y and Hu J Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice PLoS ONE .2013; 6: 8.
  54. Sun XD, Liu XE and Huang DS. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Mol. Med. Rep. 2012; 6:1267-1270. https://doi.org/10.3892/mmr.2012.1103
  55. Taty Anna K, Elvy Suhana MR, Das S, Faizah O, Hamzaini AH. Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study. Clin.Ter. 2011; 162(3): 201-207.
  56. Thomas F. PDR for Herbal Medicines (Medical Economics Company), 2000, pp 846-847.
  57. Ungphaiboon S, Tanomjit S, Pechnoi S, Supreedee S, Pranee R, Itharat A. Study on antioxidant and antimicrobial activities of turmeric clear liquid soap for wound treatment of HIV patients. Songklanakarin J. Sci. Technol. 2005; 27(2):269-578.
  58. Vishwanath PK and Christy SB. Immunomodulatory effects of curcumin in allergy. Mol. Nutr. Food Res. 2008; 52:1031-1039. https://doi.org/10.1002/mnfr.200700293
  59. WHO. The Use of Traditional Medicine in Primary Health Care. (Delhi: ATIBS), 2004:28-29.
  60. Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer. 2011; 12:10. https://doi.org/10.1186/1476-4598-12-10
  61. Wuthi-udomlert M, Grisanapan W, Luanratana O, Caichompoo W. Antifungal activity of Curcuma longa grown in Thailand. Southeast Asian J. Trop. Med. Public Health. 2000; 1:31:178-182.
  62. Yano S , Terai M, Shimizu KL, Futagami Y, Horie S, Tsuchiya S, Ikecami F, Sekine T, Takamoto K, Saito K, Ueno K, Watanabe K. Antiallergic activity of Curcuma longa (II). Features of inhibitory actions on histamine release from mast cells. Nat. Medicines. 2000; 54:325-329.
  63. Zeng C, Zhong P, Zhao Y, Kanchana K, Zhang Y, Khan ZA, Chakrabarti S, Wu L, Wang J, Liang G. Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kappaB both in vitro and in vivo. J. Mol. Cell Cardiol. 2015; 79:1-12. https://doi.org/10.1016/j.yjmcc.2014.10.002
  64. Zheng A, Li H, Wang X, Feng Z, Xu J, Cao K, Zhou B, Wu J, Liu J. Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction. Current Cancer Drug Targets. 2014; 14: 156-166. https://doi.org/10.2174/1568009613666131126115444