Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
권호 표지
DOI QR코드

DOI QR Code

Soft tissue sarcoma in neurofibromatosis type 1: A rare case of malignant peripheral nerve sheath tumor of the skin

  • Chung, Young Hun (Department of Plastic Surgery, Kyung Hee University Graduate School) ;
  • Jang, Jin Woo (Department of Plastic Surgery, Kyung Hee University Medical Center) ;
  • Cho, Jae Young (Department of Plastic Surgery, Kyung Hee University Medical Center)
  • Received : 2019.10.16
  • Accepted : 2019.11.06
  • Published : 2020.01.15
Download PDF
⟨ Previous Next ⟩

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma originating from the sheaths of peripheral nerves. Approximately 50% of MPNSTs occur in patients with neurofibromatosis (NF). These tumors often present as deep soft tissue lesions, arising from the nerve plexuses of the extremities or from the nerves extending from the trunk. They rarely occur in the skin, especially in patients with NF. Herein, we report our experience with an MPNST of the skin in a patient with NF.

Keywords

References

  1. Evans DG, Baser ME, McGaughran J, et al. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 2002;39:311-4. https://doi.org/10.1136/jmg.39.5.311
  2. Ferner RE, Gutmann DH. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res 2002;62:1573-7.
  3. Kim DH, Lee SS, Lee SH, et al. A case of malignant peripheral nerve sheath tumor of the neck associated with neurofibromatosis type I. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:657-60. https://doi.org/10.3342/kjorl-hns.2010.53.10.657
  4. Luzar B, Falconieri G. Cutaneous malignant peripheral nerve sheath tumor. Surg Pathol Clin 2017;10:337-43. https://doi.org/10.1016/j.path.2017.01.008
  5. Farid M, Demicco EG, Garcia R, et al. Malignant peripheral nerve sheath tumors. Oncologist 2014;19:193-201. https://doi.org/10.1634/theoncologist.2013-0328
  6. George E, Swanson PE, Wick MR. Malignant peripheral nerve sheath tumors of the skin. Am J Dermatopathol 1989; 11:213-21. https://doi.org/10.1097/00000372-198906000-00004
  7. Thomas C, Somani N, Owen LG, et al. Cutaneous malignant peripheral nerve sheath tumors. J Cutan Pathol 2009; 36:896-900. https://doi.org/10.1111/j.1600-0560.2008.01151.x
  8. Park CH, Kim HS, Lee JH, et al. A case of malignant peripheral nerve sheath tumor in nasal cavity. Korean J Otorhinolaryngol-Head Neck Surg 2008;51:376-9.
  9. Jo VY, Fletcher CD. Epithelioid malignant peripheral nerve sheath tumor: clinicopathologic analysis of 63 cases. Am J Surg Pathol 2015;39:673-82. https://doi.org/10.1097/PAS.0000000000000379
  10. Luzar B, Shanesmith R, Ramakrishnan R, et al. Cutaneous epithelioid malignant peripheral nerve sheath tumour: a clinicopathological analysis of 11 cases. Histopathology 2016;68:286-96. https://doi.org/10.1111/his.12756
  11. Inoue T, Kuwashiro M, Misago N, et al. Superficial malignant peripheral nerve sheath tumor arising from diffuse neurofibroma in a neurofibromatosis type 1 patient. J Dermatol 2014;41:631-3. https://doi.org/10.1111/1346-8138.12536
  12. Dietrich V, Schaller J, Kunze J. Cutaneous malignant peripheral nerve sheath tumor in neurofibromatosis type 1. Hautarzt 2009;60:830-3. https://doi.org/10.1007/s00105-008-1700-2
  13. Lee HS, Lee CH, Jin SM, et al. A case of malignant peripheral nerve sheath tumor in parapharyngeal space. Korean J Otorhinolaryngol-Head Neck Surg 2012;55:181-4. https://doi.org/10.3342/kjorl-hns.2012.55.3.181
  14. Hannah CE, Moye MS, Liu V, et al. Cutaneous metastases of malignant peripheral nerve sheath tumor: ineffectiveness of intralesional methotrexate. JAAD Case Rep 2018;4:716-8. https://doi.org/10.1016/j.jdcr.2018.04.011
  15. Thway K, Fisher C. Malignant peripheral nerve sheath tumor: pathology and genetics. Ann Diagn Pathol 2014;18: 109-16. https://doi.org/10.1016/j.anndiagpath.2013.10.007