Neonatal Medicine

  • 제27권4호
  • /
  • Pages.159-166
  • /
  • 2020
  • /
  • 2287-9412(pISSN)
  • /
  • 2287-9803(eISSN)
대한신생아학회 (The Korean Society of Neonatology)
권호 표지
DOI QR코드

DOI QR Code

Neurodevelopmental Outcomes of Moderate-to-Late Preterm Infants

  • Nam, Yun Sung (Department of Pediatrics, Korea University College of Medicine) ;
  • Heo, Ju Sun (Department of Pediatrics, Korea University College of Medicine) ;
  • Byeon, Jung Hye (Department of Pediatrics, Korea University College of Medicine) ;
  • Lee, Eun Hee (Department of Pediatrics, Korea University College of Medicine)
  • 투고 : 2020.05.17
  • 심사 : 2020.09.01
  • 발행 : 2020.11.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Preterm infants are known to be at a risk of neurodevelopmental delay; however, limited data are available on the outcomes of moderate-to-late preterm (MLPT) infants (born at 32 to 36 weeks' gestation). The Korean Developmental Screening Test (K-DST) for infants and children is a recently designed screening test for Korean infants and children. The current study aimed to evaluate the neurodevelopmental outcomes of MLPT infants and investigate the risk factors associated with neurodevelopmental delay. Methods: A total of 119 MLPT infants admitted to a neonatal intensive care unit (NICU) of a tertiary hospital in Korea were enrolled. The infants were assessed during two follow-up periods (first: 16 to 24 months of corrected age; second: 24 to 41 months of corrected age). The perinatal factors in the NICU that were associated with delayed development were analyzed. Results: In all sections of the K-DST, the proportion of infants with developmental delay was higher in the second period (5.6% to 9.3%) than in the first period (0.9% to 5.4%). A total of 10% to 17% of the infants presented with persistent delay throughout the two periods based on five sections of the K-DST. Male sex, oxygen therapy duration, and younger maternal age were the risk factors affecting at least one section during the second period. Conclusion: MLPT infants showed greater developmental delay than the general infant population. Considering that early intervention is important for good long-term outcomes, close observation of male MLPT infants and MLPT infants who received oxygen therapy is warranted.

키워드

참고문헌

  1. Raju TN, Higgins RD, Stark AR, Leveno KJ. Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development. Pediatrics 2006;118:1207-14. https://doi.org/10.1542/peds.2006-0018
  2. March of Dimes Birth Defects Foundation; World Health Organization; Partnership for Maternal, Newborn & Child Health; Save the Children. Born too soon: the global action report on preterm birth. Geneva: World Health Organization, 2012.
  3. Cheong JL, Doyle LW, Burnett AC, Lee KJ, Walsh JM, Potter CR, et al. Association between moderate and late preterm birth and neurodevelopment and social-emotional development at age 2 years. JAMA Pediatr 2017;171:e164805. https://doi.org/10.1001/jamapediatrics.2016.4805
  4. Johnson S, Matthews R, Draper ES, Field DJ, Manktelow BN, Marlow N, et al. Early emergence of delayed social competence in infants born late and moderately preterm. J Dev Behav Pediatr 2015;36:690-9. https://doi.org/10.1097/dbp.0000000000000222
  5. Tomashek KM, Shapiro-Mendoza CK, Davidoff MJ, Petrini JR. Differences in mortality between late-preterm and term singleton infants in the United States, 1995-2002. J Pediatr 2007;151:450-6. https://doi.org/10.1016/j.jpeds.2007.05.002
  6. Ohgi S, Fukuda M, Akiyama T, Gima H. Effect of an early intervention programme on low birthweight infants with cerebral injuries. J Paediatr Child Health 2004;40:689-95. https://doi.org/10.1111/j.1440-1754.2004.00512.x
  7. Resnick MB, Armstrong S, Carter RL. Developmental intervention program for high-risk premature infants: effects on development and parent-infant interactions. J Dev Behav Pediatr 1988;9:73-8.
  8. Korea Centers for Disease Control and Prevention. Korean-development screening test for infants and children. Cheongju: Korea Centers for Disease Control and Prevention, 2014.
  9. Yim CH, Kim GH, Eun BL. Usefulness of the Korean Developmental Screening Test for infants and children for the evaluation of developmental delay in Korean infants and children: a single-center study. Korean J Pediatr 2017;60:312-9. https://doi.org/10.3345/kjp.2017.60.10.312
  10. Pascal A, Govaert P, Oostra A, Naulaers G, Ortibus E, Van den Broeck C. Neurodevelopmental outcome in very preterm and very-low-birthweight infants born over the past decade: a meta-analytic review. Dev Med Child Neurol 2018;60:342-55. https://doi.org/10.1111/dmcn.13675
  11. World Health Organization. ICD-10: international statistical classification of diseases and related health problems: tenth revision. 2nd ed. Geneva: WHO, 2004.
  12. Sung IK, Vohr B, Oh W. Growth and neurodevelopmental outcome of very low birth weight infants with intrauterine growth retardation: comparison with control subjects matched by birth weight and gestational age. J Pediatr 1993;123:618-24. https://doi.org/10.1016/S0022-3476(05)80965-5
  13. Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. Pediatrics 2005;116: 635-43. https://doi.org/10.1542/peds.2004-2247
  14. Jin JH, Yoon SW, Song J, Kim SW, Chung HJ. Long-term cognitive, executive, and behavioral outcomes of moderate and late preterm at school age. Clin Exp Pediatr 2020;63:219-25. https://doi.org/10.3345/kjp.2019.00647
  15. Suh CR, Sohn SY, Kim GH, Jung SK, Eun BL. Single-center experience of the Korean-Developmental Screening Test for infants and children. Korean J Pediatr 2016;59:483-49. https://doi.org/10.3345/kjp.2016.59.12.483
  16. Chan E, Leong P, Malouf R, Quigley MA. Long-term cognitive and school outcomes of late-preterm and early-term births: a systematic review. Child Care Health Dev 2016;42:297-312. https://doi.org/10.1111/cch.12320
  17. Chyi LJ, Lee HC, Hintz SR, Gould JB, Sutcliffe TL. School outcomes of late preterm infants: special needs and challenges for infants born at 32 to 36 weeks gestation. J Pediatr 2008;153:25-31. https://doi.org/10.1016/j.jpeds.2008.01.027
  18. Johnson S, Evans TA, Draper ES, Field DJ, Manktelow BN, Marlow N, et al. Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study. Arch Dis Child Fetal Neonatal Ed 2015;100:F301-8. https://doi.org/10.1136/archdischild-2014-307684
  19. Petrini JR, Dias T, McCormick MC, Massolo ML, Green NS, Escobar GJ. Increased risk of adverse neurological development for late preterm infants. J Pediatr 2009;154:169-76. https://doi.org/10.1016/j.jpeds.2008.08.020
  20. Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, et al. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics 2009;124:112-21. https://doi.org/10.1542/peds.2008-2742
  21. Hirvonen M, Ojala R, Korhonen P, Haataja P, Eriksson K, Gissler M, et al. Visual and hearing impairments after preterm birth. Pediatrics 2018;142:e20173888. https://doi.org/10.1542/peds.2017-3888
  22. Leversen KT, Sommerfelt K, Ronnestad A, Kaaresen PI, Farstad T, Skranes J, et al. Prediction of neurodevelopmental and sensory outcome at 5 years in Norwegian children born extremely preterm. Pediatrics 2011;127:e630-8. https://doi.org/10.1542/peds.2010-1001
  23. Serenius F, Kallen K, Blennow M, Ewald U, Fellman V, Holmstrom G, et al. Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden. JAMA 2013;309:1810-20. https://doi.org/10.1001/jama.2013.3786
  24. Guihard-Costa AM, Larroche JC. Differential growth between the fetal brain and its infratentorial part. Early Hum Dev 1990;23:27-40. https://doi.org/10.1016/0378-3782(90)90126-4
  25. Kapellou O, Counsell SJ, Kennea N, Dyet L, Saeed N, Stark J, et al. Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. PLoS Med 2006;3:e265. https://doi.org/10.1371/journal.pmed.0030265
  26. Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr 2006;95:1239-48. https://doi.org/10.1080/08035250600599727
  27. Reiss AL, Kesler SR, Vohr B, Duncan CC, Katz KH, Pajot S, et al. Sex differences in cerebral volumes of 8-year-olds born preterm. J Pediatr 2004;145:242-9. https://doi.org/10.1016/j.jpeds.2004.04.031
  28. Anderson PJ, Doyle LW. Neurodevelopmental outcome of bronchopulmonary dysplasia. Semin Perinatol 2006;30:227-32. https://doi.org/10.1053/j.semperi.2006.05.010
  29. Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, et al. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 2005;116:1353-60. https://doi.org/10.1542/peds.2005-0249
  30. Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics 2005;115:1645-51. https://doi.org/10.1542/peds.2004-2215
  31. Natarajan G, Pappas A, Shankaran S, Kendrick DE, Das A, Higgins RD, et al. Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition. Early Hum Dev 2012;88:509-15. https://doi.org/10.1016/j.earlhumdev.2011.12.013
  32. Trittmann JK, Nelin LD, Klebanoff MA. Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates. Eur J Pediatr 2013;172:1173-80. https://doi.org/10.1007/s00431-013-2016-5
  33. Vohr BR, Tyson JE, Wright LL, Perritt RL, Li L, Poole WK, et al. Maternal age, multiple birth, and extremely low birth weight infants. J Pediatr 2009;154:498-503. https://doi.org/10.1016/j.jpeds.2008.10.044
  34. DiLabio J, Zwicker JG, Sherlock R, Daspal S, Shah PS, Shah V, et al. Maternal age and long-term neurodevelopmental outcomes of preterm infants<29 weeks gestational age. J Perinatol 2020 Jul 21 [Epub]. https://doi.org/10.1038/s41372-020-0735-9.

피인용 문헌

  1. An Early Collaborative Intervention Focusing on Parent-Infant Interaction in the Neonatal Period. A Descriptive Study of the Developmental Framework vol.18, pp.12, 2021, https://doi.org/10.3390/ijerph18126656