Mycobiology

The Korean Society of Mycology (한국균학회)
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Cumulative Effects of Constituents from the Mushroom Calvatia nipponica on the Contractility of Penile Corpus Cavernosum Smooth Muscle

  • Lee, Seulah (School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Min-Ji (College of Pharmacy, Kyungsung University) ;
  • Lee, Bum Soo (School of Pharmacy, Sungkyunkwan University) ;
  • Ryoo, Rhim (Special Forest Products Division, Forest Bioresources Department, National Institute of Forest Science) ;
  • Kim, Hye Kyung (College of Pharmacy, Kyungsung University) ;
  • Kim, Ki Hyun (School of Pharmacy, Sungkyunkwan University)
  • Received : 2020.01.08
  • Accepted : 2020.02.13
  • Published : 2020.04.30
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Abstract

Calvatia nipponica, a puffball mushroom (Agaricaceae), is thought to be an aphrodisiac, as this mushroom is traditionally known to improve sexual function in males. As part of the systematic study to determine the bioactive secondary metabolites from C. nipponica responsible for aphrodisiac effects, chemical analysis of methanol (MeOH) extracts of the fruiting bodies of C. nipponica resulted in the isolation of two major compounds: N,N-dimethyl-anthranilic acid (1) and (7Z,10Z)-7,10-octadecadienoic acid methyl ester (2). Compounds 1 and 2 were evaluated for cumulative dose-dependent relaxation responses to precontracted penile corpus smooth muscle (PCCSM). Results show that compounds 1 and 2 exhibited a maximum relaxation effect of 20.33 ± 2.18% and 24.63 ± 3.60%, respectively. These findings indicate that compounds 1 and 2, major components of C. nipponica, could potentially be used to treat erectile dysfunction, functioning as natural aphrodisiacs.

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References

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