Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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An analysis of Clinical Studies on Galgeun-tang

갈근탕의 임상연구 논문 분석

  • Song, Si-Young (Department of Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Kang, Yu-Seon (Department of Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Byeon, Sung-hee (Department of Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Lee, Soong-In (Department of Herbal Formula Science, College of Korean Medicine, Dongshin University)
  • 송시영 (동신대학교 한의과대학 방제학교실) ;
  • 강유선 (동신대학교 한의과대학 방제학교실) ;
  • 변성희 (동신대학교 한의과대학 방제학교실) ;
  • 이숭인 (동신대학교 한의과대학 방제학교실)
  • Received : 2019.10.17
  • Accepted : 2019.11.18
  • Published : 2020.02.28
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Abstract

Objective : This study's purpose was to review the clinical studies of Galgeun-tang. Method : We searched papers about Galgeun-tang using KISS, RISS, OASIS, PUBMED and J-stage. The key words we used were "Galgeuntang", "Kakkonto", "Ge gen tang", and "Pueraria Decoction". Papers not matched with inclusion criteria were excluded. Results : Until today, there have been 223 studies on Galgeun-tang. Of these, 25 studies were classified as clinical research papers. There were 4 cases of fever, 5 cases of inflammation on respiratory system, 3 cases of head, neck and shoulder disorder, 2 cases of diarrhea, 6 cases of pharmacokinetics and interaction, 5 cases of side effect. Conclusion : It can be seen that Galgeun-tang has established the basis for application to the purpose of treating fever (common cold, influenza), inflammation on respiratory system (nasal obstruction, maxillary sinus retention cyst, mucoid pseudomonas aeruginosa chronic lower respiratory tract infection), head, neck and shoulder disorder (temporomandibular disorders, shoulder stiffness, tetanus), and diarrhea. On the other hand, considering 4 cases of side effect on drug eruption, caution should be exercised when observing the progress of the patient taking Galgeun-tang.

Keywords

References

  1. Lee SI, Cho HR. The comparisons of Shanghanlun. Bucheon : Korean medical association of clinical Sanghan geumgwe. 2015 : 22,24.
  2. Moon JJ, Ahn GS, Kim SH, Park WS, Song MD, Park JH, Kim DH, Kim SW, Choi DY, Shin YI, Ji GY, Shin SW, Ha GT, Lee SG, Kim JB, Lee GG, Kim YM. Shanghanlunjeonghae. Seoul : Publicaton HanEuiMunHwaSa. 2010 : 112.
  3. Kook YB, Kim SC, Park SD, Park SG, Seo BI, Seo YB, Shin SS, Lee SI, Lee JC, Lee CG, Joo YS, Choi HY. Formula study. Seoul : Younglimsa. 2006 : 1-620.
  4. Hwang PS. Bangyakhappyeon. Seoul : Namsandang. 1992 : 1-373.
  5. Yoon YG. Explanation of oriental medicine formula and prescription. Seoul : Uiseongdang. 2007 : 229-33.
  6. Heo J. Dongeuibogam. Seoul : Namsandang. 1992 : 567.
  7. Ministry of health and welfare. Partial amendment of salary list and price ceiling table of traditional Korean medicine formula. 2019 July 29. retrieved 2019 August 12. Available from : URL : http : //www.mohw.go.kr/react/jb/sjb0406vw.jsp?PAR_MENU_ID=03&MENU_ID=030406&page=1&CONT_SEQ=350343
  8. Healthcare bigdata hub. Claim status by prescription name of traditional Korean medicine formula (Health insurance). 2019 July 17. retrieved 2019 August 12. Available from : URL : http : //kosis.kr/statHtml/statHtml.do?orgId=354&tblId=DT_354004N_027&vw_cd=MT_OTITLE&list_id=&seqNo=&lang_mode=ko&language=kor&obj_var_id=&itm_id=&conn_path=K2
  9. Kim DY. Japanese doctors actively use herbal medicines. - Oriental medicine market increased 1.5 times in last 10 years. 2018 August 24. retrieved 2019 August 14. Available from : URL : http : //www.akomnews.com/bbs/board.php?bo_table=news&wr_id=27477
  10. Liang HF, Yang YH, Chen PC, Kuo HC, Chang CH, Wang YH, Wu KM. Prescription patterns of traditional Chinese medicine amongst Taiwanese children : a population- based cohort study. BMC complementary and alternative medicine. 2018 ; 18(1) : 191. https://doi.org/10.1186/s12906-018-2261-2
  11. Ye SA, Kim HJ, KO SG, Song YG. Influence of Galgeun-tang on gene expression in diet-induced obese mice. Journal of oriental rehabilitation medicine. 2016 ; 26(2) : 1-12.
  12. Qi SH, Kim HJ, Ko SG, Song YG. Antiobesity effects of Galgeun-tang in high fat diet induced obese mice model. Journal of oriental rehabilitation medicine. 2016 ; 26(2) : 13-28.
  13. Lee HW. Compound screening and analysis for standardization of quality of Galgung tang extract granule. Kyunghee graduate school ; Master's thesis. 2017 : 1-25.
  14. Shin GM. Screening of anti-aging substances from Galgeun-tang and Galgeun. Wonkwang graduate school : doctoral dissertation. 2007 : 1-96.
  15. Park SY. (The) Repaired effect of the crude extracts from Galgeuntang on NIH3T3 fibroblasts against cadmium-induced cytotoxicity. Wonkwang graduate school : Master's thesis. 2006 : 1-44.
  16. Cho DY. Effect of Gal-geun-tang on antigen-specific immunce response. Wonkwang graduate school : doctoral dissertation. 2005 : 1-40.
  17. Kwak GS. Effect of commercial Gal geun tang on antioxidative abilities. Kyungnam graduate school : master's thesis. 2003 : 1-35.
  18. Kwon CH. Influences of Galgeun-tang administration on stress responses in rats. Youngnam graduate school : Doctoral dissertation. 1975 : 1-26.
  19. Nho JH, Jang JH, Lee MJ, Yang BD, Woo KW, Lee HJ, Kim AH, Sim MO, Cho HW, Jung HK. Safety evaluation test of Galgeuntang applied to guidelines for the testing of chemicals. Journal of korean society of medical crop science. 2019 ; 27(3) : 173-85. https://doi.org/10.7783/KJMCS.2019.27.3.173
  20. Oh SY, Seo SH, Lee JH, Lee JS, Ma JY. Protective effect of Galgeun-tang against TEX>$CCl_4$ induced hepatotoxicity. Journal of physiology & pathology in korean medicine. 2011 ; 25(4) : 663-8.
  21. Kang E, Ryu H, Kim Y, Kim K. A case report of patient with type 2 diabetes mellitus treated with Galgeun-tang. J Int Korean Med. 2017 ; 38(5) : 541-7. https://doi.org/10.22246/jikm.2017.38.5.541
  22. Han EJ, Kim YB. A case of maxillary sinus retention cysts with symptoms of rhinosinusitis. The journal of oriental medical opthalmology & otolaryngology & dermatology. 2003 ; 16(1) : 191-7.
  23. Lee JK, Kim JH, Shin HK. Systematic studies on Galgeun-tang for establishment of evidence based medicine. Herbal formula science. 2011 ; 19(1) : 103-11. https://doi.org/10.14374/HFS.2011.19.1.103
  24. Nozaki Y. Study of the signs and symptoms at the early feverish stage in children. Japanese oriental medical journal. 1985 ; 36(1) : 35-42.
  25. Okabayashi S, Goto M, Kawamura T, Watanabe H, Kimura A, Uruma R, Takahashi Y, Taneichi S, Musashi M, Miyaki K. Non-superiority of Kakkonto, a Japanese herbal medicine, to a representative multiple cold medicine with respect to anti-aggravation effects on the common cold : a randomized controlled trial. Intern Med. 2014 ; 53 : 949-56. https://doi.org/10.2169/internalmedicine.53.1783
  26. Okita M, Yayoshi Y, Ohara K, Negishi A, Akimoto H, Inoue N, Numajiri S, Ohshima S, Honma S, Oshima S, Kobayashi D. Comparison of the benefit feeling rate based on the sho of OTC Kakkonto, cold remedy and cold remedy with Kakkonto combination product. Biol Pharm Bull. 2017 ; 40 : 1730-38. https://doi.org/10.1248/bpb.b17-00340
  27. Tanaka H. The prophylaxis Kakkonto prevents the onset of the infulenza virus among pregnant women after contacting infected influenza families. Kampo Med. 2018 ; 69(3) : 291-94. https://doi.org/10.3937/kampomed.69.291
  28. Ishioka T, Aoi R. Anti-inflammatory action of Kakkontou. Jpn Clin Pharmacol Ther. 1991 ; 22(1) : 273-74. https://doi.org/10.3999/jscpt.22.273
  29. Kurokouchi A. Beneficial effect of Kakkon-to on nasal obstruction due to neurolepticus. Kampo Med. 1992 ; 43(2) : 319-24. https://doi.org/10.3937/kampomed.43.319
  30. Irifune K. Effect of Alinamin F and Kakkontou on mucoid Pseudomonas aeruginosa chronic lower respiratory tract infection. Nihon kokyuki gakkai Zasshi. 2009 ; 47(3) : 218-21.
  31. Matsumoto K. Application of Chinese medicine heat-clearing formula and exterior-releasing formula on various allergic diseases. Japanese journal of ryodoraku autonomic neurology. 1987 ; 32(8) : 157-61.
  32. Sano K, Araki M, Ogawa A. Minoda Y. Terasaki H, Murakami H, Ninomiya H, Hironaka R, Ito Y, Kitamura A, Inokuchi T. Clinical evaluation of the traditional herbal treatment with Kakkon-to for the temporomandibular disorders. Japanese journal of oral and maxillofacial surgery. 1987 ; 33(8) : 1684-90. https://doi.org/10.5794/jjoms.33.1684
  33. Yakubo S, Komaki K, Yagi H, Kanmatsuse K. The effects of Kakkon-to on shoulder stiffness and neck body surface temperature by thermotracer. Kampo medicine. 1997 ; 47(5) : 795-802. https://doi.org/10.3937/kampomed.47.795
  34. Nakae H, Saito Y, Okuyama M, Igarashi T. A case of tetanus treated with Kampo medicines such as Kakkonto and Shakuyakukanzoto. Acute Med Surg. 2016 ; 4(2) : 217-20. https://doi.org/10.1002/ams2.254
  35. Miyasaka T. Kampo-treatment for infantile diarrhoea 1st report. Journal of the japan society for oriental medicine. 1962 ; 13(1) : 42-8.
  36. Miyasaka T. Casuistics of the infantile diarrhoea by Kampo-treatment 3rd report. Journal of the japan society for oriental medicine. 1964 ; 15(1) : 28-31.
  37. Chan KH, Pan RN, Hsu MC, Hsu KF. Urinary elimination of ephedrines following administration of the traditional Chinese medicine preparation Kakkon-to. J Anal Toxicol. 2008 ; 32(9) : 763-7. https://doi.org/10.1093/jat/32.9.763
  38. Inotsume N, Fukushima S, Hayakawa T, Kishimoto S, Yanaguimoto H, Toda T, Goto N, Imai S. Pharmacokinetics of ephedrine and pseudoephedrine after oral administration of Kakkonto to healthy male volunteers. Rinsho yakuri/Japanese journal of clinical pharmacology and therapeutics. 2009 ; 40(3) : 79-83. https://doi.org/10.3999/jscpt.40.79
  39. Ishii T, Mineshita S, Tsuchida M, Sanaka M, Shimakura K, Takano K, Park Y, Wang L, Honda Y. The effect of Kakkonto on the dynamics of acetaminophen in the combination on human. Jpn J Clin Pharmacol Ther. 1992 ; 23(1) : 105-6. https://doi.org/10.3999/jscpt.23.105
  40. Shimakura K, Mineshita S, Sanaka M, Yamamoto T, Wang L, Honda Y. Effects of Kakkonto on the kinetics of phenacetin in human serum and saliva. Jpn J Clin Pharmacol Ther. 1994 ; 25(1) : 229-30. https://doi.org/10.3999/jscpt.25.229
  41. Qi J, Toyoshima A, Mineshita S. The interaction between acetaminophen and Kakkonto. Jpn J Clin Pharmacol Ther. 1996 ; 27(1) : 251-2. https://doi.org/10.3999/jscpt.27.251
  42. Qi J, Toyoshima A, Honda Y, Mineshita S. Pharmacokinetic study on acetaminophen: interaction with a Chinese medicine. J Med Dent Sci. 1997 ; 44(1) : 31-5.
  43. Matsumoto K, Mikoshiba H, Saida T. Nonpigmenting solitary fixed drug eruption caused by a Chinese traditional herbal medicine, ma huang, mainly containing pseudoephedrine and ephedrine. J Am Acad Dermatol. 2003 ; 48(4) : 628-30. https://doi.org/10.1067/mjd.2003.192
  44. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2000 ; 343 : 1833-8. https://doi.org/10.1056/NEJM200012213432502
  45. Akita H, Sowa J, Makiura M, Akamatsu H, Matsunaga K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto. Contact Dermatitis. 2003 ; 48(6) : 348-9. https://doi.org/10.1034/j.1600-0536.2003.00151.x
  46. Fujimoto N, Tajima S. Extensive fixed drug eruption due to the Japanese herbal drug kakkon-to. Br J Dermatol. 2003 ; 149(6) : 1303-5. https://doi.org/10.1111/j.1365-2133.2003.05676.x
  47. Nishiyama A, Ishida T, Yoshioka H, Tachibana H, Hashimoto T. Drug-induced Pneumonitis due to Kakkonto taken to prevent the common cold. The Journal of the Japan Society for Respiratory Endoscopy. 2016 ; 38(2) : 140-3.
  48. Takashi I. Examination of frequency and nature of side effects caused by Over-thecounter Kampo formulations based on the data published by the Japanese ministry of health, labour and welfare. Kampo Med. 2016 ; 67(2) : 184-90. https://doi.org/10.3937/kampomed.67.184
  49. Lee JD. The most commonly used 101 prescription. Seoul : Jungdam. 2004 : 1-1051.
  50. Otsuka K. Explanation in symptomatical practice of Kampo medicine. Wonju : Publication Euibang. 2013 : 6-7,50-1,448,541, 545-8,561,599-600,698-700,732,736-42,750 ,778-84,821,852-7,937-8.
  51. Feung S. Six meridians and formula of Shanghanlun. Daegu : Omniherb. 2012 : 145-7.
  52. Whalen K. Lippincott's illustrated review : Pharmacology 6th Edition. Seoul : Shinil Books. 2015 : 90.
  53. Jung GM. Oriental pediatrics. Seoul : Publication Hanglim. 1996 : 1-741.
  54. Kim KB, Kim DK, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yoo SA, Lee SY, Lee JY, Jang KT, Jeong MJ, Chae JW, Chun JH, Han YJ, Han JK. Traditional Korean medicine for Pediatrics. Seoul : Uiseongdang. 2015 : 1-570.
  55. Ko CN. Hong SW. Yoon YH. Herbal medicine prescription guide for Otolaryngology. Paju : Publication Gunja. 2017 : 34,42,74,141,158,217,243.
  56. Abe K, Takagi K. Comparison of treatments on upper respiratory infection in children by Kampo medicines and modern medicines. Kampo Medicine. 1993 ; 43(4) : 509-15. https://doi.org/10.3937/kampomed.43.509
  57. Miura O, Kono Y, Itakura H, Tanaka K, Hashiguchi M. Profiles of a cold by oriental medicine approach, Statistical analysis of 147 cases symptom. Kampo Med. 2011 ; 62(2) : 120-32. https://doi.org/10.3937/kampomed.62.120
  58. Lee SG. New traditional korean medicine for clinical otorhinolaryngology. Seoul : Jungdam. 2007 : 57
  59. The society of Korean medicine rehabilitation. Korean medicine rehabilitation. Seoul : Publication Gunja. 2015 : 1-456.
  60. Wikipedia. Phenacetin. 2019 July 2. retrieved 2019 August 12. Available form : URL : https://en.wikipedia.org/wiki/Phenacetin