The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지
DOI QR코드

DOI QR Code

Review for Clinical Studies of Oriental Medicine on the Prevention of Ovarian Hyperstimulation Syndrome

난소과자극증후군의 예방에 관한 한의 임상 연구 고찰

  • Ku, Su-Jeong (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
  • 구수정 (경희대학교 대학원 임상한의학과) ;
  • 황덕상 (경희대학교 한의과대학 부인과교실) ;
  • 이진무 (경희대학교 한의과대학 부인과교실) ;
  • 이창훈 (경희대학교 한의과대학 부인과교실) ;
  • 장준복 (경희대학교 한의과대학 부인과교실)
  • Received : 2020.01.05
  • Accepted : 2020.02.28
  • Published : 2020.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This review is aimed at assessing the efficacy and effectiveness of oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome (OHSS) through literature research and overview. Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) on oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome. Studies were searched from Journal of Korean Obstetrics and Gynecology, Korean studies Information Service System, Korean Medical Database, China National Knowledge Infrastructure, Cochrane library, PubMed and EmBase up to 7th November, 2019. Results: Ten RCTs were finally selected. Eight studies intervened with oral Chinese herb medicine, one is intervened with Chinese medicine enema and the other with acupuncture. Eight studies concluded that intervention with oriental medicine significantly decreased OHSS incidence. Five studies showed significantly higher pregnancy rate in the intervention groups. Two studies reported higher ovulation rate and other two studies showed more maturated eggs than the control groups. Four studies showed opposite results in serum Estradiol level. Vascular Endothelial Growth Factor level was significantly lower in the intervention groups in two studies. Conclusions: From ten studies, oriental medicine reduced OHSS incidence rate and showed preventable effectiveness. Further strictly designed studies and acupuncture intervened studies are needed to establish evidences.

Keywords

References

  1. Mourad S, Brown J, Farquhar C. Interventions for the prevention of OHSS in ART cycles: an overview of Cochrane reviews. Cochrane Database of Systematic Reviews. 2017;Issue 1:1-55. https://doi.org/10.1002/14651858.cd009593.pub2
  2. Seok HH, et al. Clinical manifestations and risk factors of severe ovarian hyperstimulation syndrome by IVF-ET. J Korean Obstet Gynecol. 2008;51(6):634-40.
  3. Kim HO, Kang IS. Prediction and Prevention of Ovarian Hyperstimulation Syndrome. Korean J of Reprodcutive Med. 2010;37(4):293-305.
  4. Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertility and Sterility. 2016;106(7):1634-47. https://doi.org/10.1016/j.fertnstert.2016.08.048
  5. Society of Korean Medicine Obstetrics & Gynecology. Oriental Obstetrics & Gynecology. Seoul:Yisungdang. 2012:469, 539.
  6. Healthcare Bigdata Hub. Statistics by KDC[Cited November 29, 2019]. Available from http://opendata.hira.or.kr/op/opc/olap4thDsInfo.do.
  7. Kim JA, Kim DC. A Case Report of Ovarian Hyperstimulation Syndrome with Edema of Left Leg by In Vitro Fertilization. J Korean Obstet Gynecol. 2014;27(4):141-9. https://doi.org/10.15204/jkobgy.2014.27.4.141
  8. Koh JE, Lyou MS. 4 positive progress reports about herb treatment's infertility patients with ovarian cysts and the menstrual irregularity due to Ovarian Hyperstimulation Syndrome. J Korean Obstet Gynecol. 2018;31(2):103-12. https://doi.org/10.15204/JKOBGY.2018.31.2.103
  9. Yuan Y, Qu XW, Wang HF. Effect and mechanism of the prevention and treatment of OHSS(Kidney-Deficiency) by Bushen huoxue formula after IVF (IVF取卵后应用补肾活血方防治肾气虚型卵巢过度刺激综合征的临床结局与机制研究). Information on Traditional Chinese Medicine. 2019;36(2):26-30.
  10. Chen XL, et al. Efficacy of Chenpi Duzhong decoction on preventing ovarian hyperstimulation syndrome (陈皮杜仲水在预防卵巢过度刺激综合征中的临床应用). Clinical J of Chinese Medicine. 2018;36(10):66-8.
  11. Chen XY, et al. Effect of Yiqixue Buganshen Recipe on the level of serum VEGF in high-risk patients with ovarian hyperstimulation syndrome(益气血补肝肾中药对卵巢过度刺激综合征患者血管内皮生长因子的影响). J of Practical Medicine. 2017;33(16):2788-91.
  12. Zhu J, Chen ZM. Theory of syndrome differentiation in the treatment of oulatory infertility(中医辨证治疗排卵性不孕). Jilin J of Chinese Medicine. 2017;37(7):703-5.
  13. Zhou B, Wang B. Clinical study on prevention and treatment of ovarian hyperstimulation syndrome by promoting ovulation(促排卵汤防治卵巢过度刺激综合征临床研究). Shandong J of Traditional Chinese Medicine. 2008;27(11):746-7.
  14. Lu HX. Analysis of therapeutic effect on ovarian hyperstimulation syndrome decreased by herbal enema decorporation (中药灌肠防止卵巢过度刺激综合征疗效分析). J of Practical Traditional Chinese Medicine. 2015;31(2):88-9.
  15. Lu YB, et al. Effect of Wenyang Jianpi Chinese Medicine on preventing ovarian hyper-stimulation syndrome during in vitro fertilization-embryo transfer(温阳健脾中药干预体外受精-胚胎移植周期卵巢过度刺激综合征的临床研究). J of Zhejiang Chinese Medical University. 2013;37(10):1171-6.
  16. Ge MX, et al. Clinical Research of Kidney-tonifying, Spleen-strengthening and Damp-eliminating Chinese Herbal Medicine in preventing and treating ovarian hyperstimulation syndrome in in-vitro fertilization and embryo transfer cycle(补肾健脾利湿中药在体外受精-胚胎移植周期中防治卵巢过度刺激综合征的临床研究). J of Guangzhou University of Traditional Chinese Medicine. 2012;29(3):257-60.
  17. Wei AW. Three-step method of promotion of blood circulation in the prevention of ovarian hyperstmiulation syndrome and the impact on the result of pregnancy(活血三步法对卵巢过度刺激征的防治及对妊娠结局的影响). Liaoning J of Traditional Chinese Medicine. 2009;36(1):76-7.
  18. Hong YL, et al. Influence of electroacupuncture -assisted intervention on ovarian hyperstimulation syndrome during in vitro fertilization-embryo transplantation (体外受精-胚胎移植过程中电针辅助干预对卵巢过度刺激综合征发生的影响). J of Beijing University of Traditional Chinese Medicine. 2014;37(9):644-8. https://doi.org/10.3969/j.issn.1006-2157.2014.09.017
  19. Al-Shawaf T, Grudzinskas JG. Prevention and treatment of ovarian hyperstimulation syndrome. Best Practice and Research : Clinical Obstetrics and Gynaecology. 2003;17(2):249-61. https://doi.org/10.1016/S1521-6934(02)00127-X
  20. Wang ZY, Zhang YZ. Advances in prevention and treatment of ovarian hyperstimulation syndrome(卵巢过度刺激综合征的预防及治疗研究进展). Heral of Medicine. 2016;35(1):62-6.
  21. Golan A, Weissman A. Symposium : Update on prediction and management of OHSS. A modern classification of OHSS. Reproductive BioMedicine Online. 2009;19(1):28-32. https://doi.org/10.1016/S1472-6483(10)60042-9
  22. Zivi E, Simon A, Laufer N. Ovarian Hyperstimulation Syndrome : Definition, Incidence, and Classification. Seminars in Reproductive Medicine. 2010;28(6):441-7. https://doi.org/10.1055/s-0030-1265669
  23. Du J, et al. Clinical study on treatment of ovarian hyperstimulation syndrome with Jianpi Lishui method(健脾利水 法治疗卵巢过度刺激综合征临床研究). Asia-Pacific Traditional Medicine. 2016;12(12):108-9.
  24. Sun YZ, et al. Clinical Observation on Treatment of Ovarian Hyperstimulation Syndrome with Traditional Chinese Medicine(中西医结合治疗卵巢过度刺激综合征临床观察). J of Practical Traditional Chinese Medicine. 2007;23(10):660-1.
  25. Xin MW. Lianfang's experience in preventing ovarian hyperstimulation syndrome(连方预防卵巢过度刺激综合征的经验). J of Shandong Univ. of traditional Chinese medicine. 2007;31(6):476-7. https://doi.org/10.3969/j.issn.1007-659X.2007.06.014
  26. Li XH, Li HH. Clinical Observation on Treatment of Ovarian Hyperstimulation Syndrome with Traditional Chinese Medicine(中西医结合治疗卵巢过度刺激综合征临床观察). J of Emergency in Traditional Chinese Medicine. 2015;24(6):1088-90. https://doi.org/10.3969/j.issn.1004-745X.2015.06.053
  27. Zhang Q, Zhang YZ, Zhang L. Application progress of traditional Chinese medicine enema in different diseases(中药灌肠法在不同疾病中的应用进展). Asia-Pacific traditional medicine. 2012;8(5):206-7.
  28. Yang T. Mechanism of acupuncture on decreasing the OHSS incidence in IVF-ET treatment(针刺疗法降低IVFET中OHSS发生的机制研究). Department of Clinical Medicine, Graduate School, LanZhou University. 2013.
  29. Chen L, et al. Electroacupuncture decreases the progression of ovarian hyperstimulation syndrome in a rat model. Reproductive BioMedicine Online. 2016;32(5):538-44. https://doi.org/10.1016/j.rbmo.2016.02.006
  30. Geva E, Jaffe RB. Role of vascular endothelial growth factor in ovarian physiology and pathology. Fertility and Sterility. 2000;74(3):429-38. https://doi.org/10.1016/S0015-0282(00)00670-1