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Perspectives on Spinal Dysraphism : Past, Present, and Future

  • Pang, Dachling (Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children, NHS Trust)
  • Received : 2020.01.25
  • Accepted : 2020.04.28
  • Published : 2020.05.01

Abstract

This article recounts the author's personal views and recollections of the history, conception of embryogenetic theories, application of intraoperative electrophysiology, and development of prospective treatment recommendations of several important spinal dysraphic malformations, including limited dorsal myeloschisis, dermal sinus tract, retained medullary cord, terminal myelocystocoele, and complex spinal cord lipomas.

Keywords

References

  1. Dady A, Havis E, Escriou V, Catala M, Duband JL : Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects. J Neurosci 34 : 13208-13221, 2014 https://doi.org/10.1523/JNEUROSCI.1850-14.2014
  2. Eibach S, Moes G, Hou YJ, Zovickian J, Pang D : Unjoined primary and secondary neural tubes: junctional neural tube defect, a new form of spinal dysraphism caused by disturbance of junctional neurulation. Child Nerv Sys 33 : 1633-1647, 2017 https://doi.org/10.1007/s00381-016-3288-7
  3. Eibach S, Moes G, Zovickian J, Pang D : Limited dorsal myeloschisis and associated dermoid elements. Child Nerv Sys 33 : 55-67, 2017 https://doi.org/10.1007/s00381-016-3207-y
  4. Lee JY, Kim SP, Kim SW, Park SH, Choi JW, Phi JH, et al. : Pathoembryogenesis of terminal myelocystocele: terminal balloon in secondary neurulation of the chick embryo. Child Nerv Sys 29 : 1683-1688, 2013 https://doi.org/10.1007/s00381-013-2196-3
  5. Pang D : Split cord malformation: part II: clinical syndrome. Neurosurgery 31 : 481-500, 1992 https://doi.org/10.1227/00006123-199209000-00011
  6. Pang D : Surgical management of complex spinal cord lipomas: how, why, and when to operate. A Review. J Neurosurg Pediatr 23 : 537-556, 2019 https://doi.org/10.3171/2019.2.PEDS18390
  7. Pang D, Dias MS, Ahab-Barmada M : Split cord malformation: part I: a unified theory of embryogenesis for double spinal cord malformations. Neurosurgery 31 : 451-480, 1992 https://doi.org/10.1227/00006123-199209000-00010
  8. Pang D, Hou YJ, Wong ST : Classification of spinal dysraphic malformations according to embryogenesis: gastrulation defects and split cord malformation in DiRocco C, Pang D, Rutka J (eds) : Textbook of Paediatric Neurosurgery. Springer Publishers : Cham
  9. Pang D, Zovickian J, Lee JY, Moes GS, Wang KC : Terminal myelocystocele: surgical observations and theory of embryogenesis. Neurosurgery 70 : 1383-1405; discussion 1404-1405, 2012 https://doi.org/10.1227/NEU.0b013e31824c02c0
  10. Pang D, Zovickian JG, Moes GS : Retained medullary cord in humans: late arrest of secondary neurulation. Neurosurgery 68 : 1500-1519; discussion 1519, 2011 https://doi.org/10.1227/NEU.0b013e31820ee282
  11. Pang D, Zovickian J, Oviedo A : Long-term outcome of total and neartotal resection of spinal cord lipomas and radical reconstruction of the neural placode: part I-surgical technique. Neurosurgery 65 : 511-528; discussion 528-529, 2009 https://doi.org/10.1227/01.NEU.0000350879.02128.80
  12. Pang D, Zovickian J, Oviedo A : Long-term outcome of total and neartotal resection of spinal cord lipomas and radical reconstruction of the neural placode, part II: outcome analysis and preoperative profiling. Neurosurgery 66 : 253-273; discussion 272-273, 2010 https://doi.org/10.1227/01.NEU.0000363598.81101.7B
  13. Pang D, Zovickian J, Oviedo A, Moes GS : Limited dorsal myeloschisis: a distinctive clinicopathological entity. Neurosurgery 67 : 1555-1579; discussion 1579-1580, 2010 https://doi.org/10.1227/NEU.0b013e3181f93e5a
  14. Pang D, Zovickian J, Wong ST, Hou YJ, Moes GS : Limited dorsal myeloschisis: a not-so-rare form of primary neurulation defect. Childs Nerv Syst 29 : 1459-1484, 2013 https://doi.org/10.1007/s00381-013-2189-2
  15. Pang D, Zovickian J, Wong ST, Hou YJ, Moes GS : Surgical treatment of complex spinal cord lipomas. Childs Nerv Syst 29 : 1485-1513, 2013 https://doi.org/10.1007/s00381-013-2187-4
  16. Wong ST, Kan A, Pang D : Limited dorsal spinal nondisjunctional disorders: Limited dorsal myeloschisis, Congenital spinal dermal sinus tract, and mixed lesions in DiRocco C, Pang D, Rutka J (eds) : Textbook of Paediatric Neurosurgery. Springer Publishers : Cham
  17. Yang HJ, Wang KC, Chi JG, Lee MS, Lee YJ, Kim SK, et al. : Neural differentiation of caudal cell mass (secondary neurulation) in chick embryos: Hamburger and Hamilton stages 16-45. Brain Res Dev Brain Res 142 : 31-36, 2003 https://doi.org/10.1016/S0165-3806(03)00009-9