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Terminal Myelocystocele : Pathoembryogenesis and Clinical Features

  • Lee, Ji Yeoun (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital) ;
  • Kim, Kyung Hyun (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital) ;
  • Wang, Kyu-Chang (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital)
  • 투고 : 2020.03.04
  • 심사 : 2020.03.31
  • 발행 : 2020.05.01

초록

There has been confusion in the classification of terminal myelocystocele (TMCC) due to its diverse morphology and vague pathoembryogenesis. TMCC could be summarized as having the essential features of an elongated caudal spinal cord extruding out of the dorsal extraspinal space that fuses with the subcutaneous fat, which is in the shape of a trumpet-shaped cerebrospinal fluid-filled cyst. The extraspinal portion of the extruded spinal cord is nonfunctional. The morphological features suggest that TMCC is formed during secondary neurulation, specifically the failure of the degeneration of the secondary neural tube near the time of the terminal balloon. This review discusses the definition, as well as the clinical and surgical features, of TMCC with special emphasis on its pathoembryogenesis.

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참고문헌

  1. Barkovich AJ, Kuzniecky RI, Dobyns WB : Radiologic classification of malformations of cortical development. Curr Opin Neurol 14 : 145-149, 2001 https://doi.org/10.1097/00019052-200104000-00002
  2. Byrd SE, Harvey C, McLone DG, Darling CF : Imaging of terminal myelocystoceles. J Natl Med Assoc 88 : 510-516, 1996
  3. Choi S, McComb JG : Long-term outcome of terminal myelocystocele patients. Pediatr Neurosurg 32 : 86-91, 2000 https://doi.org/10.1159/000028905
  4. Lee JY, Phi JH, Kim SK, Cho BK, Wang KC : Urgent surgery is needed when cyst enlarges in terminal myelocystoceles. Childs Nerv Syst 27 : 2149-2153, 2011 https://doi.org/10.1007/s00381-011-1532-8
  5. McLone DG, Naidich TP : Terminal myelocystocele. Neurosurgery 16 : 36-43, 1985 https://doi.org/10.1227/00006123-198501000-00008
  6. Pang D, Zovickian J, Lee JY, Moes GS, Wang KC : Terminal myelocystocele: surgical observations and theory of embryogenesis. Neurosurgery 70 : 1383-1404; discussion 1404-1405, 2012 https://doi.org/10.1227/NEU.0b013e31824c02c0
  7. Tandon V, Garg K, Mahapatra AK : Terminal myelocystocele: a series of 30 cases and review of the literature. Pediatr Neurosurg 48 : 229-235, 2012 https://doi.org/10.1159/000349915
  8. Yang HJ, Lee DH, Lee YJ, Chi JG, Lee JY, Phi JH, et al. : Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens. Childs Nerv Syst 30 : 73-82, 2014 https://doi.org/10.1007/s00381-013-2192-7
  9. Yang HJ, Wang KC, Chi JG, Lee MS, Lee YJ, Kim SK, et al. : Neural differentiation of caudal cell mass (secondary neurulation) in chick embryos: Hamburger and Hamilton Stages 16-45. Brain Res Dev Brain Res 142 : 31-36, 2003 https://doi.org/10.1016/S0165-3806(03)00009-9