Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity

  • Cai, Mudan (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Jung, Inho (Department of Life and Nanopharmaceutical Science, Kyung Hee University) ;
  • Kwon, Huiyoung (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Cho, Eunbi (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Jeon, Jieun (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Yun, Jeanho (Department of Biochemistry, College of Medicine, Dong-A University) ;
  • Lee, Young Choon (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Kim, Dong Hyun (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
  • Received : 2019.05.03
  • Accepted : 2019.11.07
  • Published : 2020.03.01
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Abstract

Hippocampal synaptic dysfunction is a hallmark of Alzheimer's disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy. In the present study, we investigated spinosin as a regulating agent of synaptic plasticity in AD. Spinosin attenuated amyloid β (Aβ)-induced long-term potentiation (LTP) impairment, and improved plasmin activity and protein level in the hippocampi of 5XFAD mice, a transgenic AD mouse model. Moreover, the effect of spinosin on hippocampal LTP in 5XFAD mice was prevented by 6-aminocaproic acid, a plasmin inhibitor. These results suggest that spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity.

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References

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