DOI QR코드

DOI QR Code

파킨슨병의 신경영상 기법을 이용한 침치료 임상 연구 논문에 대한 고찰

Review of Studies on Clinical Trials of Acupuncture Treatment for Parkinson's Disease Using Neuroimaging Methods

  • 이동혁 (한국과학기술원 의과학대학원)
  • Lee, Dong Hyuk (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)
  • 투고 : 2020.03.01
  • 심사 : 2020.03.27
  • 발행 : 2020.04.20

초록

Objectives: The purpose of this study was to investigate the current state of clinical trials for acupuncture treatment of Parkinson's disease (PD) using neuroimaging methods. Methods: We searched for clinical trial studies of acupuncture treatment for Parkinson's disease that used neuroimaging methods in the MEDLINE (PubMed) database. The identified studies were then selected manually based on inclusion criteria. We subsequently analyzed the characteristics of the selected articles and reviewed the neural substrates of acupuncture treatment in PD. Results: Eight studies were included. The most frequently applied modality for PD was functional MRI. The most frequently selected acupoint for PD was GV34. Several studies showed that acupuncture treatment could improve the symptoms of PD. Through the analysis, we demonstrated that the neuroimaging method could capture the neural substrates associated with PD and that acupuncture treatment may affect the activation of brain areas that are impaired in PD in a different way than sham acupuncture. Conclusions: Applying a neuroimaging method could be helpful in clinical trials of acupuncture treatment for PD, and more efforts should be made in this area.

키워드

참고문헌

  1. Alves G, Forsaa EB, Pedersen KF, Dreetz Gjerstad M, Larsen JP. Epidemiology of Parkinson's disease. J Neurol 2008 Sep;255(5):18-32. https://doi.org/10.1007/s00415-008-5004-3
  2. 국민건강보험 건강보험 통계. https://nhiss.nhis.or.kr
  3. Dickson DW. Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2012 Aug 1;2(8):a009258 https://doi.org/10.1101/cshperspect.a009258
  4. Brammer M. The role of neuroimaging in diagnosis and personalized medicine-current position and likely future directions. Dialogues Clin Neurosci 2009;11(4):389-96. https://doi.org/10.31887/DCNS.2009.11.4/mbrammer
  5. Bega D, Zadikoff C. Complementary & alternative management of Parkinson's disease: an evidencebased review of eastern influenced practices. J Mov Disord 2014 Oct;7(2):57-66. https://doi.org/10.14802/jmd.14009
  6. Chae YB, Lee HJ, Kim H, Kim CH, Chang DI, Kim KM, et al. Parsing brain activity associated with acupuncture treatment in Parkinson's diseases. Mov Disord 2009 Sep 15;24(12):1794-802. https://doi.org/10.1002/mds.22673
  7. Yeo SJ, Lim SBN, Choe IH, Choi YG, Chung KC, Jahng GH, et al. Acupuncture stimulation on GB34 activates neural responses associated with Parkinson's disease. CNS Neurosci Ther 2012 Sep;18(9):781-90. https://doi.org/10.1111/j.1755-5949.2012.00363.x
  8. Yeo S, Choe IH, van den Noort M, Bosch P, Jahng GH, Rosen B, et al. Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease. BMC Complement Altern Med 2014 Sep 15;14:336. https://doi.org/10.1186/1472-6882-14-336
  9. Yeo S, van den Noort M, Bosch P, Lim S. A study of the effects of 8-week acupuncture treatment on patients with Parkinson's disease. Medicine (Baltimore) 2018 Dec;97(50):e13434. https://doi.org/10.1097/md.0000000000013434
  10. Li Z, Chen J, Cheng J, Huang S, Hu Y, Wu Y, et al. Acupuncture Modulates the Cerebello-Thalamo-Cortical Circuit and Cognitive Brain Regions in Patients of Parkinson's Disease with Tremor. Front Aging Neurosci 2018;10:206. https://doi.org/10.3389/fnagi.2018.00206
  11. Yu SW, Lin SH, Tsai CC, Chaudhuri KR, Huang YC, Chen YS, et al. Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease. Front Neurol 2019;10:1114. https://doi.org/10.3389/fneur.2019.01114
  12. Huang Y, Jiang X, Zhuo Y, Tang A, Wik G. Complementary acupuncture treatment increases cerebral metabolism in patients with Parkinson's disease. Int J Neurosci 2009;119(8):1190-7. https://doi.org/10.1080/00207450802336774
  13. Huang Y, Jiang X, Zhuo Y, Wik G. Complementary acupuncture in Parkinson's disease: a spect study. Int J Neurosci 2010 Feb;120(2):150-4. https://doi.org/10.3109/00207450903316527
  14. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord 2015 Oct;30(12):1591-601. https://doi.org/10.1002/mds.26424
  15. Niethammer M, Feigin A, Eidelberg D. Functional neuroimaging in Parkinson's disease. Cold Spring Harb Perspect Med 2012;2(5):a009274. https://doi.org/10.1101/cshperspect.a009274
  16. Johnson KA, Fox NC, Sperling RA, Klunk WE. Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med 2012;2(4):a006213. https://doi.org/10.1101/cshperspect.a006213
  17. Wise T, Cleare AJ, Herane A, Young AH, Arnone D. Diagnostic and therapeutic utility of neuroimaging in depression: an overview. Neuropsychiatr Dis Treat 2014;10:1509-22.
  18. Shenton ME, Whitford TJ, Kubicki M. Structural neuroimaging in schizophrenia: from methods to insights to treatments. Dialogues Clin Neurosci 2010;12(3):317-32. https://doi.org/10.31887/DCNS.2010.12.3/mshenton
  19. Ko JH, Lee H, Kim SN, Park HJ. Does Acupuncture Protect Dopamine Neurons in Parkinson's Disease Rodent Model?: A Systematic Review and Meta-Analysis. Front Aging Neurosci 2019 May 8;11:102. https://doi.org/10.3389/fnagi.2019.00102
  20. Kim SN, Doo AR, Park JY, Bae H, Chae Y, Shim I, et al. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PLoS One 2011;6(11):e27566. https://doi.org/10.1371/journal.pone.0027566
  21. Yeo S, Song J, Lim S. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Adv Exp Med Biol 2020;1232:401-8. https://doi.org/10.1007/978-3-030-34461-0_51
  22. Jeon HJ, Yoo TW, Kim DS, Kwon SO, Kim ST. Neuroprotective Mechanism of Acupuncture at GB34 for Dopaminergic Neurons in the Striatum of a Parkinson's Disease Mouse Model. Korean J Acupunct 2015;32:108-15. https://doi.org/10.14406/acu.2015.017