Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Efficacy of Herbal Medicine as an Adjunctive Therapy of Chemotherapy for Cervical Cancer: A Systematic Review and Meta-analysis

  • Oh, Seung Yun (Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Kim, Mi Suk (Department of Third Medicine of Korean Medicine, Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Joo, Jong Cheon (Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Song, Yung Sun (Department of Third Medicine of Korean Medicine, Professional Graduate School of Korean Medicine, Wonkwang University)
  • Received : 2020.09.24
  • Accepted : 2020.10.15
  • Published : 2020.10.25
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Abstract

This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized controlled trials with HM combined with CT to treat cervical cancer were included. A total of 21 trials were included for analysis. Compared to the control group, HM combined with CT group significantly increased tumor response (complete and partial response) (risk ratio [RR] = 1.24, 95% CI: 1.15-1.33, p < 0.00001) and Karnofsky performance score (standardized mean difference [SMD] = 1.71, 95% CI: 1.41-2.01, p < 0.00001). Also, HM combined with CT group remarkably reduced CT toxicity. In Conclusion, our study suggests that HM might be a potential option for cervical cancer to enhance curative efficacy and reduce CT toxicity.

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References

  1. Arbyn M, Weiderpass E, Bruni L, de Sanjose S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191-e203. https://doi.org/10.1016/s2214-109x(19)30482-6
  2. Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends-An Update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16. https://doi.org/10.1158/1055-9965.EPI-15-0578
  3. Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169-82. https://doi.org/10.1016/S0140-6736(18)32470-X
  4. Vale C, Thierny JF, Stewart LA. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol. 2008;26(35):5802-12. https://doi.org/10.1200/JCO.2008.16.4368
  5. Hsiao YH, Lin CW, Wang PH, Hsin MC, Yang SF. The Potential of Chinese Herbal Medicines in the Treatment of Cervical Cancer. Integr Cancer Ther. 2019;18:1534735419861693.
  6. Chung VC, Wu X, Hui EP, Ziea ET, Ng BF, Ho RS, et al. Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses. Sci Rep. 2015;5:18111. https://doi.org/10.1038/srep18111
  7. Wang R, Sun Q, Wang F, Liu Y, Li X, Chen T, et al. Efficacy and Safety of Chinese Herbal Medicine on Ovarian Cancer After Reduction Surgery and Adjuvant Chemotherapy: A Systematic Review and Meta-Analysis. Front Oncol. 2019;9:730. https://doi.org/10.3389/fonc.2019.00730
  8. Yan XY, Yan ZS, Liu WC, Ding H, Qiao SZ, Chen G, et al. External application of traditional Chinese medicine in the treatment of bone cancer pain: a meta-analysis. Support Care Cancer. 2016;24(1):11-7. https://doi.org/10.1007/s00520-015-2737-2
  9. Higgins JPT, Altman DG. Chapter 8: assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions, version 5.0.1. West Sussex, England: John Wiley & Sons Ltd. 2008:214-72.
  10. Chang ZL, Sheng XB, Shi XL, Wei W. Effect of synergism and attenuation of Guizhi Fuling decoction in patients with advanced cervical cancer treated with chemotherapy. J Capit Univ Med Sci. 2018;39(4):596-601.
  11. Gong SX, You JL, Ren CX. Clinical effect of Fuzheng Yin 1 combined with TP chemotherapy in the treatment of cervical cancer. Acta Chin Med Pharm. 2018;46(01):98-100.
  12. Han L, Long LX, Tuo XY. Treating 36 cases of cervical carcinoma after laparoscopic operation by integrative medicine therapy. West J Tradit Chin Med. 2016;29(6):98-9.
  13. Jian XL, Jiang YL, Zeng PH. Clinical efficacy of modified Fuzheng Xiaozheng formula combined with chemotherapy in treatment of advanced cervical cancer: a report of 21 cases. Hunan J Tradit Chin Med. 2015;31(06):1-3.
  14. Li LD, Xu WF. Effect of Fuzheng Guben decoction combined with chemotherapy on immune function in cervical cancer patients. Beijing J Tradit Chin Med. 2017;36(04):362-4.
  15. Li CX, Li SH. Effect of cisplatin and docetaxel chemotherapy combined with Zhenqi Fuzheng Granule on cervical cancer. Drug Eval Res. 2019;42(3):501-4.
  16. Liu JZ. Analysis on the effectivenesss of integrative medicine treatment for advanced cervical cancer. Electron J Clin Med Lit. 2019;6(61):18-9.
  17. Nan F, Chen CH. Study on the clinical efficacy on 30 cases of cervical cancer treated with integrated Chinese and Western medicine. World J Integr Tradit West Med. 2015(11):1586-8. https://doi.org/10.13935/j.cnki.sjzx.151132
  18. Qin YY, Wei ZY, Han FX. Clinical efficacy and safety analysis of Fuzheng Guben decoction combined with chemotherapy for cervical cancer. J Guangzhou Univ Tradit Chin Med. 2016;33(03):321-4.
  19. Sun M, Zhao Y, Yang TR, Tang XT, Ren Y. Effect of Fuzheng Guben decoction on the levels of SCC-Ag and TSGF in patients with cervical cancer. Anti-tumor pharm. 2019;9(01):120-4, 138.
  20. Wang AL. Clinical efficacy and safety analysis of fuzhengguben soup combined with chemotherapy on cevical cancer. China J Mod Med. 2014;24(22):51-3.
  21. Wen LF, Ding J. Effect of modified Renshen Yangrong tang combined with chemotherapy on serum tumor markers and Th1/Th2-type cytokines expression in cervical cancer patients. Chin J Exp Tradit Med Formulae. 2019;25(05):68-72.
  22. Wu Y. Effect of Fuzheng Guben decoction combined with chemotherapy for cervical cancer. China Prac Med. 2017;12(24):107-8.
  23. Xu LZ, Qi CJ. Clinical efficacy of Fuzheng Guben decoction combined with chemotherapy for cervical cancer. Diet Health. 2018;5(9):92.
  24. Xu SL, Ming Y, Li K. Effectiveness of Fuzheng Guben decoction combined with chemotherapy for cervical cancer. Home Med. 2019(8):134.
  25. Yang M. Clinical effect of Fuzheng Guben decoction combined with chemotherapy for cervical cancer. J Pract Tradit Chin Med. 2015;31(11):1036-7.
  26. Yang HL. Effect of Jiawei Renshenyangrong decoction on immune function and quality of life of cervical cancer patients. Acta Chin Med. 2017;32(08):1377-80.
  27. Yang XY, Wang LH. Clinical analysis of Sanxian Baogong decoction combined with cisplatin and paclitaxel in treatment of advanced cervical cancer. Chin Arch Tradit Chin Med. 2018;36(08):1936-9.
  28. Zhang ZW, Ni ML. Effect of Sanxian Baogong decoction combined with paclitaxel and cisplatin in treatment of middle and advanced cervical cancer. J Pract Gynecol Endocrinol. 2015(3):73-5.
  29. Zhu P, Li J. Effects of Fuzheng Yiliu decoction combined with chemotherapy on the levels of T cell subsets, serum tumor markers expression and survival rate in patients with middle and advanced cervical cancer. Forum Tradit Chin Med. 2019;34(01):18-20.
  30. Zuo MF. Clinical efficacy of self-made Qinggan Lishi decoction in the treatment of patients with cervical cancer chemotherapy. Hebei Med. 2019;25(07):1226-31.
  31. Feng Z, Yang R, Wu L, Tang S, Wei B, Guo L, et al. Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway. Onco Targets Ther. 2019;12:7111-21. https://doi.org/10.2147/OTT.S219623
  32. Li Y, Gong L, Qi R, Sun Q, Xia X, He H, et al. Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression. Drug Des Devel Ther. 2017;11:2481-91. https://doi.org/10.2147/DDDT.S134518
  33. Liao KF, Chiu TL, Huang SY, Hsieh TF, Chang SF, Ruan JW, et al. Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition. Cell Physiol Biochem. 2018;48(6):2231-46. https://doi.org/10.1159/000492641
  34. Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, et al. Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo. Indian J Pharmacol. 2012;44(1):78-81. https://doi.org/10.4103/0253-7613.91872
  35. Zhao LH, Ma ZX, Zhu J, Yu XH, Weng DP. Characterization of polysaccharide from Astragalus radix as the macrophage stimulator. Cell Immunol. 2011;271(2):329-34. https://doi.org/10.1016/j.cellimm.2011.07.011
  36. Wu TH, Yeh KY, Wang CH, Wang H, Li TL, Chan YL, et al. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function. J Oncol. 2019;2019:9206951.
  37. Efferth T, Saeed MEM, Mirghani E, Alim A, Yassin Z, Saeed E, et al. Integration of phytochemicals and phytotherapy into cancer precision medicine. Oncotarget. 2017;8(30):50284-304. https://doi.org/10.18632/oncotarget.17466
  38. Xie L, Bourne PE. Developing multi-target therapeutics to fine-tune the evolutionary dynamics of the cancer ecosystem. Front Pharmacol. 2015;6:209. https://doi.org/10.3389/fphar.2015.00209

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