Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Systemic Analysis of Antibacterial and Pharmacological Functions of Scutellariae Radix

시스템 약리학적 분석에 의한 황금의 항균효과

  • Kim, Hyo Jin (School of Korean Medicine, Pusan National University) ;
  • Bak, Se Rim (School of Korean Medicine, Pusan National University) ;
  • Ha, Hee Jung (School of Korean Medicine, Pusan National University) ;
  • Kim, Youn Sook (School of Medicine, Pusan National University) ;
  • Lee, Boo Kyun (School of Korean Medicine, Pusan National University) ;
  • An, Won Gun (School of Korean Medicine, Pusan National University)
  • 김효진 (부산대학교 한의학전문대학원) ;
  • 박세림 (부산대학교 한의학전문대학원) ;
  • 하희정 (부산대학교 한의학전문대학원) ;
  • 김윤숙 (부산대학교 의학전문대학원) ;
  • 이부균 (부산대학교 한의학전문대학원) ;
  • 안원근 (부산대학교 한의학전문대학원)
  • Received : 2020.05.06
  • Accepted : 2020.08.10
  • Published : 2020.08.25
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Abstract

This study was performed to find antibacterial substances contained in Scutellariae Radix (SR) using a systems pharmacological analysis method and to establish an effective strategy for the prevention and treatment of infectious diseases. Analysis of the main active ingredients of SR was performed using Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. 36 active compounds were screened by the parameter values of Drug-Likeness (DL), Oral Bioavailability (OB), and Caco-2 permeability (Caco-2), which were based on the drug absorption, distribution, metabolism, and excretion indicators. The UniProt database was used to obtain information on 159 genes associated with active compounds. The main active compounds with antibacterial effects were wogonin, β-sitosterol, baicalein, acacetin and oroxylin-A. Target proteins associated with the antibacterial action were chemokine ligand 2, interleukin-6, tumor necrosis factor, caspase-8,9 and mitogen-activated protein kinase 14. In the future, systems pharmacological analysis of traditional medicine will be able to make it easy to find the important mechanism of action of active substances present in natural medicines and to optimize the efficacy of medicinal effects for combinations of major ingredients to help treat certain diseases.

Keywords

References

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