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Current status and prospects of chitosan for industrial applications

키토산 관련 산업의 현황과 전망

  • 정병옥 (속초물산 붉은대게연구소)
  • Received : 2020.02.03
  • Accepted : 2020.02.17
  • Published : 2020.03.31

Abstract

For the development of the chitosan industry in Korea, the catch of red snow crabs caught on the east coast is rapidly decreasing. Therefore, it is urgent to develop raw materials that can replace the red snow crab as the top priority to solve the supply and demand problems, as well as wastewater treatment costs account for a large proportion of the cost of chitosan. In order to solve the problems, continuous research on biological extraction methods such as enzymatic extraction and microbial fermentation will increase production efficiency and lower unit cost as well as chemical extraction methods. Further efficient manufacturing method can be established. Establishing of novel techniques is indispensable for production of high-purity chitosan and the ability to regulate and separate the molecular weight, as well as joint research with industry, academia and research institute for the research and development of high-functional chitosan derivatives.

게나 새우 갑각류의 껍질로부터 추출되는 키토산은 천연고분자로서 다양한 응용분야로 폐수처리용 응집제와 중금속흡착제, 기능성 식품 및 식품첨가제, 토양개량 및 생육촉진제, 생체재료분야의 의약 및 의료용, 섬유, 화장품, 제지 등 수많은 분야에서 연구 및 상용화가 진행되고 있다. 키토산 제조의 원료인 붉은 대게 어획량이 급격히 감소하여 원료의 부족 현상을 겪고 있어, 키토산 제조에 대체 원료의 발굴이 시급히 요구되고 있는 시점에 이르고 있다. 새우와 곤충류의 껍질을 활용하기 위하여는 새우 껍질은 동남아시아 등에서 수입, 곤충류의 껍질은 국내 사육 농가의 증가로 충분한 양의 확보가 예상되어 키토산 제조의 원료로 대체하는 방법도 고려해 볼 수 있을 것이다. 키토산은 생산단계에서 강산과 강염기를 사용해서 화학반응을 시키므로 해서 많은 양의 폐수가 발생하여 환경오염은 물론 폐수처리 비용이 키토산의 원가에 큰 비중을 차지하고 있어, 키토산의 제조방법의 혁신적인 개선되지 않고서는 키토산 산업의 발전에 영향을 미칠 것으로 생각되며, 화학적 추출방법이 아닌 생물학적 추출방법(효소적 추출, 미생물 발효)에 대한 꾸준한 연구와 기술개발로 화학적 추출방법 못지 안는 생산효율을 높이고 단가를 낮출 수 있을 것으로 생각된다. 고순도 키토산의 생산과 분자량을 조절, 분리할 수 있는 기술, 고기능성 키토산 유도체의 연구개발을 위한 산·학·연의 공동연구가 절실히 요구되며 관련 기업들의 성장을 위한 제품의 혁신과 역량확대가 필연적인 과제라 할 수 있다.

Keywords

References

  1. Allran CR, Hadwiger LA. The fungicidal effect of chitosan on fungi of varying cell wall composition. Exp. Mycol. 3: 285 (1979) https://doi.org/10.1016/S0147-5975(79)80054-7
  2. Carol LL, Matthew PH. An investigation into the use of chitosan for the removal of soluble silver from industrial wastewater. Environ. Sci. Technol. 33: 3622-3626 (1999) https://doi.org/10.1021/es980443r
  3. Cho SK, Kim SJ, Jung BO, Kim JJ, Choi KS, Lee YM. Effect of wastewater treatment of partially deacetylated chitosan. J. Korean Ind. & Eng. Chem. 5(5): 899-903 (1994)
  4. Freier T, Koh HS, Kazazian K., Shoichet MS. Controlling cell adhesion and degradation of chitosan films by N-acetylation. Biomat. 26: 5872-5879 (2005) https://doi.org/10.1016/j.biomaterials.2005.02.033
  5. Huang C, Chen S, Pan JR. Optimal condition for modification of chitosan: A biopolymer for coagulation of colloids particles. Wat. Res. 34(3): 1057-1062 (2000) https://doi.org/10.1016/S0043-1354(99)00211-0
  6. Hwang HY, Rhim JW, Nam SY. Funtional chitosan membranes for pervaporation, J. Chitin Chitosan 10(4): 179-191 (2005)
  7. Jin YI, Ji MS, Kim KY, Chae GS, Chae DH, Park RD. Effect of chitin application on the early growth of Tomato. J. Korean Soc. Appl. Biol. Chem. 47: 361-365 (2004)
  8. Jo GH, Park RD, Jung WJ. Enzymatic production of chitin from crustacean shell waste. Chitin, Chitosan, Oligosaccharides and their derivatives, Boca Raton, CRC Press (2011)
  9. Jung BO, Kim CH, Choi KS, Lee YM, Kim JJ. Preparation of amphiphilic chitosan and their antimicrobial activities. J. Appl. Polym. Sci. 72: 1713-1719 (1999) https://doi.org/10.1002/(SICI)1097-4628(19990624)72:13<1713::AID-APP7>3.0.CO;2-T
  10. Jung WJ, Jo GH, Kuk JH, Kim YJ, Oh KT, Park RD. Production of chitin from red crab shell waste by successive fermentation with Lactobacillus paracasei KCTC-3074 and Serratia marcescens FS-3. Carbohydr. Polym. 68: 746-750 (2007) https://doi.org/10.1016/j.carbpol.2006.08.011
  11. Kim JT, Kang BC, Jee HK, Choi AJ, Kim CJ, Cho YJ, Kahn HKG, Nam KD. Effect of Chitosan-based feed additive on the growth and quality of cultured Japanese Flounder, Paralichthys olivaceus. J. Chitin Chitosan 10(3): 121-127 (2005)
  12. Kim SK, Jeon YJ. Chitin and chitosan as materials of functional cosmetics. J. Chitin Chitosan 2(4): 5-13 (1997)
  13. Lee KG, Lee YW, Kweon HY, Yeo JH, Park IK, Nam J, Seol KY. Structural characteristics of insect chitin/chitosan. Korean J. Seric. Sci. 40(2): 158-162 (1998)
  14. Lee B, Jung BO, Son T, Kim CH. A Study on the chitosan derivative having anionic carboxy groups and their flocculating characteristics. J. Chitin Chitosan 8(1): 24-27 (2003)
  15. Lee HS, Park HY, Choi YJ, Kim JJ, Jung BO, Chung SJ. Effect of chitosans on bread properties and shelf life. Appl. Chem. 4: 113-136 (2000)
  16. Lee JW, You J, Kim KH, Park YS. R&D Trend of chitin and chitosan in Japan, J. Chitin Chitosan 10(1): 8-11 (2005)
  17. Li Q, Dunn ET, Grandmaison EW, Goosen MFA. Applications and properties of chitosan. Journal of Bioactive and Compat. Polym. 7: 370-397 (1992) https://doi.org/10.1177/088391159200700406
  18. Muzzarelli R.A.A. Chitin, Pergamon Press, Oxford, U.K.(1977)
  19. Muzzarelli R.A.A. Carboxymethylated chitins and chitosans. Carbohydr. Polym. 8: 1-21 (1988) https://doi.org/10.1016/0144-8617(88)90032-X
  20. Park GS. Quality characteristics of Muffins added with chitoologosaccharide. J. Chitin Chitosan 20(4): 237-244 (2015) https://doi.org/10.17642/jcc.20.4.3
  21. Rao MS, Munoz J, Stevens WF. Critical factors in chitin production by fermentation of shrimp biowaste. Appl. Microbiol. Biotechnol. 54: 808-813 (2000) https://doi.org/10.1007/s002530000449
  22. Rhoades J, Roller S. Antimicrobial actions of degraded and native chitosan against spoilage organisms in laboratory media and foods. Appl. Environ. Microbiol. 66: 80-86 (2000) https://doi.org/10.1128/AEM.66.1.80-86.2000
  23. 고병열, 김상우, 박영서: 키토산. 한국과학기술정보원 (2002)
  24. 농축산식품부.농촌진흥청. 국내곤충 산업규모 및 육성목표 (2019)
  25. 식품의약품안전처. 내손안식품안전정보 (2019)
  26. 중소벤처기업부. 곤충 외피 추출 키토산을 이용한 동물 창상 치료용 3D-printer bio ink 개발 (2019)
  27. 플라스틱 타임즈. 게 가재 새우 껍데기로 바이오플라스틱 생산 (2016) http://plastictimes.co.kr/news/view.html?section=2&category=149&no=527
  28. 주간경향. 뉴스메이커 758호 (2018) http://weekly.khan.co.kr/khnm.html?mode=view&artid=16537&code=116
  29. 월간식품저널. 키토산 (2001) https://www.foodnews.co.kr/bbs/list.html?table=bbs_13&idxno=50&page=1&total=12&sc_area=T&sc_word=2001
  30. 해양수산부. 어업통계 2018
  31. Market Research Report. Chitosan market size, share & trend analysis report by application (Pharmaceutical & Biomedical, Water Treatment, Cosmetics, Food & Beverage) by region(APAC, North America, Eroupe, MEA) and segment forecasts. http://grandviewresearch.com/industry-analysis/global-chitosan-market. Jun. 2017.