대한의생명과학회지 (Biomedical Science Letters)

  • 제26권1호
  • /
  • Pages.22-27
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  • 2020
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Association of the Genetic Polymorphisms for CD247 Gene and Tuberculosis Case

  • Ju, Yeongdon (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Sung-Soo (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University) ;
  • Lee, Kyung Eun (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Park, Sangjung (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University) ;
  • Jin, Hyunwoo (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
  • 투고 : 2020.03.02
  • 심사 : 2020.03.24
  • 발행 : 2020.03.31
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초록

Tuberculosis is airborne disease caused by Mycobacterium tuberculosis (MTB). Host genetic factors of these tuberculosis play an important role in determining individual difference in susceptibility or resistance to infectious diseases including tuberculosis. CD247 is named CD3zeta chain or CD3ζ. CD247 gene is a protein-coding gene involved in phagocytosis and signal transduction of the T cell receptor (TCR). Also, downregulation of the CD3ζ chain has been associated to chronic inflammation. The aim of this study was to research association of the genetic polymorphisms for CD247 gene and tuberculosis. We analyzed association of CD247 and Mycobacterium tuberculosis using 149 imputed single nucleotide polymorphisms (SNPs) with Korean population. And the results of this study show that seven SNPs of CD247 were identified to associate with tuberculosis. The most significant SNP was rs858545 (OR=1.22, CI: 1.05~1.42, P=0.009481). This study suggests that polymorphisms of CD247 may affect the T cell receptor signaling pathway, which may associate the infection of tuberculosis.

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참고문헌

  1. Algood HM, Chan J, Flynn JL. Chemokines and tuberculosis. Cytokine Growth Factor Rev. 2003. 14: 467-477. https://doi.org/10.1016/S1359-6101(03)00054-6
  2. Boom WH, Canaday DH, Fulton SA, Gehring AJ, Rojas Re, Torres M. Human immunity to M. tuberculosis: T cell subsets and antigen processing. Tuberculosis. 2003. 83: 98-106. https://doi.org/10.1016/S1472-9792(02)00054-9
  3. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK, Oh B, Kim HL. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009. 41: 527-534. https://doi.org/10.1038/ng.357
  4. Du G, Chen CY, Shen Y, Qiu L, Huang D, Wang R, Chen ZW. TCR repertoire, clonal dominance, and pulmonary trafficking of mycobacterium-specific $CD4^+$ and $CD8^+$ T effector cells in immunity against tuberculosis. J Immunol. 2010. 185: 3940-3947. https://doi.org/10.4049/jimmunol.1001222
  5. Ersek B, Molnar V, Balogh A, Matko J, Cope AP, Buzas EI, Falus A, Nagy G. $CD3{\zeta}$-Chain Expression of Human T Lymphocytes Is Regulated by TNF via Src-like Adaptor Protein-Dependent Proteasomal Degradation. J Immunol. 2012. 189: 1602-1610. https://doi.org/10.4049/jimmunol.1102365
  6. Fogel N. Tuberculosis: a disease without boundaries. Tuberculosis. 2015. 95: 527-531. https://doi.org/10.1016/j.tube.2015.05.017
  7. Guy CS, Vignali DA. Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev. 2009. 232: 7-21. https://doi.org/10.1111/j.1600-065X.2009.00843.x
  8. Harishankar M, Selvaraj P, Bethunaickan R. Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility. Front Med. 2018. 5: 213. https://doi.org/10.3389/fmed.2018.00213
  9. HIRA. Health Insurance Review & Assessment Service. http://gisopendata.hira.or.kr/map.do.
  10. Jin HS, Park S. Association of the CD226 Genetic Polymorphisms with Risk of Tuberculosis. Biomedical Science Letters. 2017. 23: 89-95. https://doi.org/10.15616/BSL.2017.23.2.89
  11. Min J, Kim JS, Kim HW, Shin AY, Koo HK, Lee SS, Kim YK, Shin KC, Chang JH, Chun G, Lee J, Park MS, Park JS. Clinical profiles of early and tuberculosis-related mortality in South Korea between 2015 and 2017: a cross-sectional study. BMC Infect Dis. 2019. 19: 735. https://doi.org/10.1186/s12879-019-4365-9
  12. Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, Mabwe S, Makhethe L, Erasmus M, Toefy A, Mulenga H, Hanekom WA, Self SG, Bekker LG, Ryall R, Gurunathan S, DiazGranados CA, Andersen P, Kromann I, Evans T, Ellis RD, Landry B, Hokey DA, Hopkins R, Ginsberg AM, Scriba TJ, Hatherill M. Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination. N Engl J Med. 2018. 379: 138-149. https://doi.org/10.1056/NEJMoa1714021
  13. Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006. 354: 1913-1921. https://doi.org/10.1056/NEJMoa053750
  14. Seitzer U, Kayser K, Hohn H, Wacker HH, Ploetz S, Flad HD, Gerdes J, Maeurer MJ. Reduced T-cell receptor $CD3{\zeta}$-chain protein and sustained $CD3{\varepsilon}$ expression at the site of mycobacterial infection. Immunology. 2001. 104: 269-277. https://doi.org/10.1046/j.1365-2567.2001.01323.x
  15. Zhang C, Liu J, Zhong JF, Zhang X. Engineering CAR-T cells. Biomark Res. 2017. 5: 22. https://doi.org/10.1186/s40364-017-0102-y