The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Comparative Efficacy Study of Pyeongwi-san(Pingwei-san) of Digestive Tract Disease Model in Rat

소화기 질환 동물모델에서 평위산(平胃散)의 염증 완화 효과

  • Jung, Seyoung (Department of Pathology, College of Korean Medicine, Sangji University) ;
  • Jung, Sung Eun (National Development Institute of Korean Medicine) ;
  • Kim, Ji Hye (National Development Institute of Korean Medicine) ;
  • Ham, Seong Ho (National Development Institute of Korean Medicine) ;
  • Yang, Woong Mo (Department of Convergence Korean Medical Science. College of Korean Medicine, Kyung Hee University) ;
  • Kwon, Bo-In (Department of Pathology, College of Korean Medicine, Sangji University)
  • 정세영 (상지대학교 한의과대학 병리학교실) ;
  • 정성은 (한국한의약진흥원) ;
  • 김지혜 (한국한의약진흥원) ;
  • 함성호 (한국한의약진흥원) ;
  • 양웅모 (경희대학교 한의과대학 융합한의학교실) ;
  • 권보인 (상지대학교 한의과대학 병리학교실)
  • Received : 2019.10.14
  • Accepted : 2020.03.25
  • Published : 2020.03.30
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Abstract

Objectives : Pyeongwi-san is widely used in Korean medicine for acute indigestion or gastrodynia. As a therapeutic agent for digestive diseases of modern people, in order to confirm the mechanism of Pyeongwi-san on digestive tract disease and the difference of therapeutic efficacy between its formulation, a comparative efficacy test was conducted on digestive tract disease animal model. Methods : For LPS enteritis animal model, male SD rats were intraorally treated with different formulation types of Pyeongwi-san, and then intraperitoneally administered LPS one hour later to induce enteritis. After 5 hours, blood was collected and TNFα, IL-1β, IL-6 and PGE2 were confirmed by ELISA. For acute gastritis animal model, male SD rats were intraorally treated with different formulation types of Pyeongwi-san according to the prescribed concentration, and then intraorally administered 60% ethanol and 150 mM HCl one hour later to induce acute gastritis. After 5 hours, blood was collected and TNFα,IL-6 were confirmed by ELISA. Results : In the LPS-administered enteritis animal model, Pyeongwi-san decreased TNFα, IL-1β, PGE2 and especially IL-6. Pyeongwi-san also decreased IL-6 in acute gastritis animal model. In addition, there was no significant difference in efficacy between the two formulations when compared with inflammatory markers. Conclusions : The efficacy of Pyeongwi-san was confirmed in the inflammatory markers related to digestive inflammatory diseases, and the efficay between two formulations of Pyeongwi-san was relatively similar. Further studies are needed to investigate the new applicability of Pyeongwi-san on different inflammatory diseases that have similar inflammation markers identified in this experiment.

Keywords

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