한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제33권6호
  • /
  • Pages.614-623
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  • 2020
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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제비집 시알산 유래 영양전달체(Nutrient Delivery System)의 인지기능 및 운동기능 개선 효과

Improvements in Cognitive and Motor Function by a Nutrient Delivery System Containing Sialic Acid from Edible Bird's Nest

  • 김동명 ((주)케이제이엠바이오 바이오연구소 총괄연구소) ;
  • 정주영 ((주)케이제이엠바이오 바이오연구소) ;
  • 이형곤 ((주)케이제이엠바이오 바이오연구소) ;
  • 권용성 ((주)케이제이엠바이오 바이오연구소) ;
  • 백진홍 ((주)김정문알로에 생명과학연구소) ;
  • 한인석 (유타대학교 화학공학과)
  • 투고 : 2020.09.03
  • 심사 : 2020.11.07
  • 발행 : 2020.12.31
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⟨ 이전 논문 다음 논문 ⟩

초록

The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird's nest (EBN), which improves brain function in patients with Alzheimer's disease and Parkinson's disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer's disease. Also, the effect of a sialic acid NDS on Parkinson's disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer's disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson's disease by preventing neurotoxicity induced by MPTP.

키워드

과제정보

본 논문의 연구는 2018년도 한국산업기술진흥원의 재원으로 기술개발 지원사업(과제번호: N0001395)과 2020년도 중소벤처기업부의 재원으로 기획 지원사업(과제번호: S2953529)을 받아 수행되었습니다.

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