Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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Interaction of Detonation Nanodiamonds with Hispidin

  • Rhee, Changkyu (Nuclear Materials Research Division, Korea Atomic Energy Research Institute (KAERI)) ;
  • Kim, Whungwhoe (Nuclear Materials Research Division, Korea Atomic Energy Research Institute (KAERI)) ;
  • Burov, Andrey E. (Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS") ;
  • Puzyr, Alexey P. (Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS") ;
  • Bondar, Vladimir S. (Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS")
  • Received : 2020.11.19
  • Accepted : 2020.12.07
  • Published : 2020.12.28
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Abstract

Hispidin is a secondary metabolite found in numerous medicinal mushrooms that has attracted significant attention, owing to its distinct biological effects, including antioxidant, anti-inflammatory, antitumor, and cytoprotective properties. Experiments are being carried out to study the interaction of detonation nanodiamonds (DNDs) with synthetic and natural hispidin sourced from extracts of Pholiota sp. fungus. The bioluminescence method is used to determine the adsorption/desorption properties of DNDs toward hispidin. It is found that hispidin forms strong conjugates with DNDs, and the use of various eluents does not result in a significant release of the adsorbed hispidin molecules. DND-bovine serum albumin (BSA) complex, where DNDs serve as a carrier for the protein and the latter acts as a hispidin sorbent, has been developed and applied in hispidin adsorption/desorption tests. The results support the use of the DNDs as a carrier for hispidin in medical applications. They also advocate the application of the DND-BSA complex for isolating the substance from fungal extracts.

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