한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제37권6호
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  • Pages.311-316
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  • 2020
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Evaluation of Serum NT-proBNP and Cardiac Troponin I Concentrations in Dogs with Heartworm Disease

  • Lee, Tae-Rim (College of Veterinary Medicine, Chungnam National University) ;
  • Hwang, Sun-Hwee (College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung Won (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun Ho (College of Veterinary Medicine, Chungnam National University)
  • 투고 : 2020.07.01
  • 심사 : 2020.10.31
  • 발행 : 2020.12.31
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초록

Biomarkers used in dogs with heartworm disease include N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI), which are associated with damage to the myocardium. Pulmonary hypertension is one of the clinical signs of canine heartworm disease. The purpose of this study is to investigate the change in the concentration of each biomarker, severity of pulmonary hypertension and the correlation between biomarkers according to the severity of clinical signs. Five healthy dogs and 10 heartworm-infected dogs were recruited for the study. The heartworm-infected group was classified based on the history, clinical signs, and blood assay, thoracic radiography, and echocardiography after confirming the infection according to the results of the commercial ELISA kit (SNAP test, IDEXX Laboratories, Maine, USA). NT-proBNP was higher in the severely infected group than the control group (p < 0.05); cTnI was also higher in the severely infected group than the control group (p < 0.05). The pressure gradient of pulmonary hypertension was higher in the severe group than the mild group (p < 0.05). The severity of pulmonary hypertension was correlated with NT-proBNP (r = 0.818, p < 0.01), cTnI (r = 0.894, p < 0.01). When the correlation of the two serum values for each group was examined, a correlation was not found in the mild group (r = 0.707, p = 0.182), but a correlation was found in the severe group (r = 0.9, p < 0.05). NT-proBNP and cTnI were significantly increased and correlated with severe clinical signs. Pulmonary hypertension was significant higher in the severe group than in the mild group (p < 0.05). Evaluation of blood biomarker concentration and severity of pulmonary hypertension and referring to each correlation between these indicators may be helpful to assess the severity of the heartworm disease.

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참고문헌

  1. American heartworm society, Guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immititis) infection in dogs, 2020 Available at http://www.heartwormsociety.org.
  2. Atkins C. Canine and feline heartworm disease. Ettinger SJ, Feldman EC, Cote E. Textbook of veterinary internal medicine, 8th ed. St. Louis: Elsevier. 2018: 716-1333.
  3. Bowman DD, Atkins CE. Heartworm biology, treatment, and control. Vet Clin North Am Small Anim Pract 2009; 39: 1127-1158. https://doi.org/10.1016/j.cvsm.2009.06.003
  4. Carreton E, Corbera JA, Morchon R, Simon F, Juste MC, Mendez JC, Montoya-Alonso JA. Dirofilaria immitis infection in dogs: Cardiopulmonary biomarker levels. Vet Parasitol 2011; 176: 313-316. https://doi.org/10.1016/j.vetpar.2011.01.015
  5. Carreton E, Morchon R, Montoya-Alonso JA. Cardiopulmonary and inflammatory biomarkers in heartworm disease. Parasit Vectors 2017; 10(suppl2): 151-163. https://doi.org/10.1186/s13071-017-2091-y
  6. Carreton E, Morchon R, Simon F, Juste MC, Mendez JC, Montoya-Alonso JA. Cardiopulmonary and inflammatory biomarkers in the assessment of the severity of caine dirofilariosis. Vet Parasitol 2014; 206: 43-47. https://doi.org/10.1016/j.vetpar.2014.08.019
  7. Di Sacco B, Vezzoni A. Clinical classification of heartworm disease for the purpose of adding objectivity to the assessment of therapeutic efficacy of adulticidal drugs in the field. In: Soll MD, ed. Proceedings of the heartworm symposium '92. Batavia, IL American Heartworm Society. 1995: 209-214.
  8. Ettinger SJ, Farace G, Forney SD, Frye M, Beardow A. Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. J Am Vet Med Assoc 2012; 240: 171-180. https://doi.org/10.2460/javma.240.2.171
  9. Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 2013; 62(25 Suppl): D92-D99. https://doi.org/10.1016/j.jacc.2013.10.024
  10. Kitagawa H, Sasaki Y, Ishihara K, Hirano Y. Contribution of live heartworms harboring in pulmonary arteries to pulmonary hypertension in dogs with dirofilariasis. Nihon Juigaku Zasshi 1990; 52: 1211-1217. https://doi.org/10.1292/jvms1939.52.1211
  11. Lee KH, Park JS, Seo KW, Song KH. Evaluation of ST2 and NT-proBNP as cardiac biomarkers in dogs with heartworm disease. Korean J Vet Serv. 2018; 41, 79-83. https://doi.org/10.7853/KJVS.2018.41.2.79
  12. McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L. Heartworm disease in animals and humans. Adv Parasitol 2008; 66: 193-285. https://doi.org/10.1016/S0065-308X(08)00204-2
  13. Nelson RW, Couto CG. Pulmonary hypertension and Heartworm disease. In: Small Animal Internal Medicine, 6th ed. St. Louis: Elsevier. 2019: 190-210.
  14. Oyama MA, Boswood A, Connolly DJ, Ettinger SJ, Fox PR, Gordon SG, Rush JE, Sisson DD, Stepien RL, Wess G, Zannad F. Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease. J Am Vet Med Assoc 2013; 243: 71-82. https://doi.org/10.2460/javma.243.1.71
  15. Schober KE, Baade H. Doppler echocardiographic prediction of pulmonary hypertension in West Highland white terriers with chronic pulmonary disease. J Vet Intern Med 2006; 20: 912-920. https://doi.org/10.1892/0891-6640(2006)20[912:DEPOPH]2.0.CO;2
  16. Seeger W, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs S, Martinez FJ, Semigran MJ, Simonneau G, Wells AU, Vachiery JL. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol 2013; 62(25 Suppl): D109-D116. https://doi.org/10.1016/j.jacc.2013.10.036
  17. Serrano-Parreño B, Carreton E, Caro-Vadillo A, FalconCordon Y, Falcon-Cordon S, Montoya-Alonso JA. Evaluation of pulmonary hypertension and clinincal status in dogs with heartworm by RPAD. Parasit Vectors 2017; 10: 1-6. https://doi.org/10.1186/s13071-016-1943-1
  18. Song KH, Park JE, Lee DH, Lee SH, Shin HJ. Serological update and molecular characterization of Diroflaria immitits in dogs, South Korea. Res Vet Sci 2010; 88: 467-469. https://doi.org/10.1016/j.rvsc.2009.10.007
  19. Sribhen C, Kasemsant N, Kaewmokul S, Sribhen K. Blood chemistry profile and cardiac troponin T concentration in Thai stray dogs infected with heartworms. Kasetsart J (Nat Sci) 1999; 33: 251-257.
  20. Wells SM, Sleeper MM. Cardiac troponins. J Vet Emerg Crit Care 2008; 18: 235-245. https://doi.org/10.1111/j.1476-4431.2008.00307.x