DOI QR코드

DOI QR Code

Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea

  • Kim, Woojin (Department of Biomedicine Health Science, College of Medicine, Catholic University of Korea) ;
  • Chang, Yoon Kyung (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Kim, Tong-Soo (Department of Parasitology and Tropical Medicine and Inha Research Institute for Medical Sciences, Inha University School of Medicine) ;
  • Hong, Sung-Jong (Department of Medical Environmental Biology, Chung-Ang University College of Medicine) ;
  • Ahn, Hye-Jin (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Nam, Ho-Woo (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Kim, Dongjae (Department of Biomedicine Health Science, College of Medicine, Catholic University of Korea)
  • 투고 : 2020.09.20
  • 심사 : 2020.09.29
  • 발행 : 2020.10.31

초록

The purpose of this study is to find out the clusters with high toxoplasmosis risk to discuss the geographical pattern in 2 islands of Gyodong-myeon and Samsan-myeon in Ganghwa-gun, Korea. Seroepidemiological data of toxoplasmosis surveyed using rapid diagnostic tests for the residents in 2 islands from 2010 to 2013 were analyzed to detect clusters of the infection. The cluster was investigated using the SatScan program which is based on Kulldorff's scan statistic. The clusters were found with P-values in each region analyzed in the program, and the risk and patient incidence of specific areas can be examined by the values such as relative risk and log likelyhood ratio. Jiseok-ri was found to be a cluster in Gyodong-myeon and Ha-ri was the cluster in Samsan-myeon. This findings can be used to monitor and prevent toxoplasmosis infections occurring in vulnerable areas.

키워드

참고문헌

  1. Black MW, Boothroyd JC. Lytic cycle of Toxoplasma gondii. Microbiol Mol Biol Rev 2000; 64: 607-623. https://doi.org/10.1128/MMBR.64.3.607-623.2000
  2. Furtado JM, Smith JR, Belfort R Jr, Gattey D, Winthrop KL. Toxoplasmosis: a global threat. J Glob Infect Dis 2011; 3: 281-284. https://doi.org/10.4103/0974-777X.83536
  3. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol 2000; 30: 1217-1258. https://doi.org/10.1016/S0020-7519(00)00124-7
  4. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 2008; 47: 554-566. https://doi.org/10.1086/590149
  5. Song KJ, Shin JC, Shin HJ, Nam HW. Seroprevalence of toxoplasmosis in Korean pregnant women. Korean J Parasitol 2005; 43: 69-71. https://doi.org/10.3347/kjp.2005.43.2.69
  6. Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. Int J Parasitol 2009; 39: 895-901. https://doi.org/10.1016/j.ijpara.2009.02.004
  7. Choi WY, Nam HW, Kwak NH, Huh W, Kim YR, Kang MW, Cho SY, Dubey JP. Foodborne outbreaks of human toxoplasmosis. J Infect Dis 1997; 175: 1280-1282. https://doi.org/10.1086/593702
  8. Kim MH, Choi YK, Park YK, Nam HW. A toxoplasmic uveitis case of a 60-year-old male in Korea. Korean J Parasitol 2000; 38: 29-31. https://doi.org/10.3347/kjp.2000.38.1.29
  9. Park YH, Han JH, Nam HW. Clinical features of ocular toxoplasmosis in Korean patients. Korean J Parasitol 2011; 49: 167-171. https://doi.org/10.3347/kjp.2011.49.2.167
  10. Ahn HJ, Cho PY, Ahn SK, Kim TS, Chong CK, Hong SJ, Cha SH, Nam HW. Seroprevalence of toxoplasmosis in the residents of Cheorwon-gun, Gangwon-do, Korea. Korean J Parasitol 2012; 50: 225-227. https://doi.org/10.3347/kjp.2012.50.3.225
  11. Kim YH, Lee J, Ahn S, Kim TS. High seroprevalence of toxoplasmosis detected by RDT among the residents of Seokmo-do (Island) in Ganghwa-Gun, Incheon City, Korea. Korean J Parasitol. 2017; 55: 9-13. https://doi.org/10.3347/kjp.2017.55.1.9
  12. Kim YH, Lee J, Ahn S, Kim TS. Seroprevalence of toxoplasmosis with ELISA and Rapid Diagnostic Test among residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up. Korean J Parasitol. 2017; 55: 247-254. https://doi.org/10.3347/kjp.2017.55.3.247
  13. Hong SJ, Chong CK, Lee K, Kim TS, Hong YP, Ahn HJ, Kim HY, Ko AR, Kim YJ, Nam HW. Maintained seroprevalence of toxoplasmosis among the residents of Jeju island, Korea. Korean J Parasitol 2011; 49: 309-311. https://doi.org/10.3347/kjp.2011.49.3.309
  14. Song KJ, Yang Z, Chong CK, Kim JS, Lee KC, Kim TS, Nam HW. A rapid diagnostic test for toxoplasmosis using recombinant antigenic N-terminal half of SAG1 linked with intrinsically unstructured domain of gra2 protein. Korean J Parasitol 2013; 51: 503-510. https://doi.org/10.3347/kjp.2013.51.5.503
  15. Kulldorff M. A spatial scan statistic. Communications in Statistics-Theory and Methods. 1997; 26:1481-1496. https://doi.org/10.1080/03610929708831995
  16. Kulldorff M. SaTScan TM: User Guide for version 9.6 [Internet]. Available from: https://www.satscan.org/cgi-bin/satscan/register. pl/SaTScan_Users_Guide.pdf?todo=process_userguide_download.
  17. Han JH, Lee MJ. Cancer cluster detection using scan statistic. Journal of the Korean Data & Information Science Society 2016; 27:1193-1201. https://doi.org/10.7465/jkdi.2016.27.5.1193
  18. Kulldorff M. An isotonic spatial scan statistic for geographical disease surveillance. Journal of the National Institute of Public Health 1999; 48: 94-101.
  19. Azage M, Kumie A, Worku A, Bagtzoglou AC. Childhood diarrhea exhibits spatiotemporal variation in northwest Ethiopia: a SaTScan spatial statistical analysis. PLoS One 2015;10: e0144690. https://doi.org/10.1371/journal.pone.0144690