DOI QR코드

DOI QR Code

A Case Report of a Patient with Olivopontocerebellar Atrophy Improved with Chengsimyeonja-tang

청심연자탕으로 호전된 올리브교소뇌위축증 환자 치험 1례

  • Park, Jieun (Department of Sasang Constitutional Medicine, Pusan National University Korean Medicine Hospital) ;
  • Lee, Seul (Department of Sasang Constitutional Medicine, Pusan National University Korean Medicine Hospital) ;
  • Lee, Jeongyun (Department of Sasang Constitutional Medicine, Pusan National University Korean Medicine Hospital)
  • 박지은 (부산대학교한방병원 사상체질과) ;
  • 이슬 (부산대학교한방병원 사상체질과) ;
  • 이정윤 (부산대학교한방병원 사상체질과)
  • Received : 2020.12.02
  • Accepted : 2020.12.15
  • Published : 2020.12.31

Abstract

Objectives This study aimed to report significant improvement of dizziness, gait disturbance and dysarthria after treatment with Sasang constitutional medicine treatment on a Taeeumin patient with olivopontocerebellar atrophy. Methods A 53-year-old female diagnosed olivopontocerebellar atrophy about one year ago suffered from dizziness, gait disturbance and dysarthria. The patient was identified as Taeeumin Joyeol pattern and treated with Cheongsimyeonja-tang and Taegeuk acupuncture. The patient's main symptoms were observed using Global Assessment Scale (GAS) during the treatment period. In addition, the Unified Multiple System Atrophy Rating Scale (UMSARS) was used to assess the overall function of patient. Results We observed a significant improvement in symptoms of dizziness, gait disturbance and dysarthria using GAS, and UMSARS score decreased in Part I and II. Conclusions This case showed that Sasang constitutional medicine treatment can be effective treatment for Taeeumin patient with olivopontocerebellar atrophy. We consider that consistent treatment can contribute to improve the patient's quality of life.

Keywords

References

  1. Yoshio Y. A sakura Internal Medicine.11th ed. Seoul: Wooriuihakseojeok. 2020;322-5.
  2. Gilman S, Low PA, Quinn N, Albanese A, Ben-shlomo Y, Flower CJ, et al. Second consensus statement on the diagnosis of multiple system atrophy. J of the Neurological Sciences. 2008;71:670-676.3.
  3. Jung MH, Son JH, Cho KH, Mun SK, Kwon SW, Jung WS. A Case Study of Multiple System Atrophy Patient with Diplopia Using Korean Medical Treatment. J of Int Korean Medicine 2017;38(2):246-51. (Korean) DOI: https://doi.org/10.22246/jikm.2017.38.2.246
  4. Lee MS, Bae NY. A Case Study of a Taeeumin Patient with Olivopontocerebellar Atrophy Improved with Jowisengcheong-tang. J of Sasang Constitutional Medicine 2013;25(3):243-53. (Korean) DOI: https://doi.org/10.7730/JSCM.2013.25.3.243
  5. Baik YS, Jo EY, Choi HJ, Jung SH. A clinical case study on multiple system atrophy-C. J of Int Korean Med 2008;spr:119-26. (Korean)
  6. Go GY, Jang MH, Kim KY, Ahn TW. A Case Study about Soyangin Cerebellar Atrophy Patient suffering from dizziness improved by Hyeungbangjihwangtang. J of Sasang Constitutional Medicine 2013;25(3):233-42. (Korean) DOI: https://doi.org/10.7730/JSCM.2013.25.3.233
  7. Im JW, Lee JE, Yei YC, Kim YS, Cho KH, Moon SK, et al. A case report of mutiple system atrophy patient treated by Korean medicine. J of Int Korean Med 2013;spr:206-10. (Korean)
  8. Woo SJ, Baek KM, Jang WS. A case report of mutiple system atrophy in a cerebellar ataxia patient suffering from gait disturbance treated with korean medicine. J of Int Korean Medicine 2016;37(5):806-14. (Korean) DOI: https://doi.org/10.22246/jikm.2016.37.5.806
  9. Kim MJ, Won SY, Kin HY, Ryu JY, Jung ES, Yoo HR, et al. A Review of Clinical Studies for Treatment of Multiple System Atrophy Using the CNKI Database. The Journal of Internal Korean Medicine 2020;41(4):612-623. (Korean) DOI: https://doi.org/10.22246/jikm.2020.41.4.612
  10. D J burns, E Jaros. Multiple system atrophy: cellular and molecular pathology. J Clin Pathol: Mol Pathol 2001;54:419-426.
  11. Ozawa T, Paviour D, Quinn NP, Josephs KA, Sangha H, Kilford L, et al. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 2004;127:2657-71. https://doi.org/10.1093/brain/awh303
  12. Schrag A, Wenning GK, Quinn N, Ben Shlomo Y. Survival in multiple system atrophy. Mov Disord 2008;23:294-96. https://doi.org/10.1002/mds.21839
  13. Geser F, Wenning GK, Seppi K, Stampfer M, Scherfler C, Sawires M, et al. Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG). Mov Disord 2006;21:179-86. https://doi.org/10.1002/mds.20678
  14. May S, Gilman S, Sowell BB, Thomas RG, Stern MB, Colcher A, et al. Potential outcome measures and trial design issues for multiple system atrophy. Mov Disord 2007;22:2371-77. https://doi.org/10.1002/mds.21734
  15. Yabe I, Soma H, Takei A, Fujiki N, Yanagihara T, Sasaki H. MSA-C is the predominant clinical phenotype of MSA in Japan: analysis of 142 patients with probable MSA. J Neurol Sci 2006;249:115-21. https://doi.org/10.1016/j.jns.2006.05.064
  16. Savoiardo M, Strada L, Girotti F. Zimmerman RA, Grisoli M, Testa D, et al. Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology 1990;174:693-696. https://doi.org/10.1148/radiology.174.3.2305051
  17. Wenning GK, Stefanova N. Recent developments in multiple system atrophy. J Neurol 2009;256:1791-808. https://doi.org/10.1007/s00415-009-5173-8
  18. Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN. Riluzole treatment, survival and diag-study. Brain 2009;132:156-71. https://doi.org/10.1093/brain/awn291
  19. Shin SW, Lee EJ, Koh BH, Lee JH. The study on the development of diagnosis algorithm of Taeeumin symptomology. J Sasang Constitut Med. 2012;24(4):28-39. (Korean) DOI: https://doi.org/10.7730/JSCM.2012.24.4.28
  20. Cho HS. Principle and Prescription of Sansang Constitutional Medicine. Seoul: Jipmoondang; 2003, 435-447.