The Korean Journal of Health Service Management (보건의료산업학회지)

Korea Society of Health Service Management (보건의료산업학회)
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Anti-microbial Activity of Platycodon Grandiflorum Extracts Against Oral Microbes

도라지 추출물의 구강미생물에 대한 항균효과

  • Jung, So-Young (Department of Public, Environment&Public Health Studies, Yeung-nam University) ;
  • Lee, Cheon-Hee (Department of Dental Hygiene, Andong Science College) ;
  • Ahn, Sun-Ha (Department of Dental Hygiene, Kyungbuk College)
  • 정소영 (영남대학교 환경보건대학원 보건학과) ;
  • 이천희 (안동과학대학교 치위생과) ;
  • 안선하 (경북전문대학교 치위생과)
  • Received : 2019.02.24
  • Accepted : 2019.06.27
  • Published : 2019.06.30
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Abstract

Objectives: The objective of this study was to assess the antimicrobial effect of Platycodon grandiflorum extracts against oral microorganisms. Methods: The anti-microbial activity and minimal inhibitory concentration were measured the agar dilution method. Results: Platycodon grandiflorum extracts grew in the free agar plates all of the oral microorganisms. In the bark-free Platycodon grandiflorum extracts all the oral microorganisms grew in the free agar plates. Growth was inhibited at a concentration of 0.5 mg/ml. Oral microorganisms showed an absence of growth at a concentration of 1 mg/ml. Conclusions: It was confirmed that the extracts of Platycodon grandiflorum having a higher saponin content than the bark - free Platycodon grandiflorum extract showed excellent antimicrobial effect.

Objectives: 도라지 추출액을 이용하여 구강미생물에 대한 Platycodon grandiflorum 추출물의 항균 효과를 실험하고자 한다. Methods: 항균 활성 및 최소 저해 농도는 한천 희석법을 사용하여 측정하였다. 추출물 (Platycodon grandiflorum 추출물과 껍질이 없는 Platycodon grandiflorum 추출물)을 준비하고 0.0625 mg/ml, 0.125 mg/ml, 0.25 mg/ml, 0.5 mg/ml, 1 mg/ml의 농도로 한천 플레이트를 만들었다. Results: 치아우식균보다 치은염을 유발시키는 A. naeslundii, A. odontolyticus, A. viscosus 세 균주에서 더 우수한 항균효과를 나타내었으며, 껍질이 없는 도라지 추출물 보다 사포닌 함량이 더 많은 껍질이 있는 도라지 추출물에서 우수한 항균효과를 나타낸 것을 확인하였다. Conclusions: 도라지 추출물 결과에서 보듯이 천연 추출물이 구강질환을 유발시키는 치아우식균 및 잇몸질환균에 대해 항균효과가 있을 수 있음을 시사한다.

Keywords

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