Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Hippocampal and Ventricular Volumes of Idiopathic Normal-pressure Hydrocephalus and the Cerebrospinal Fluid Tap Test

특발정상압수두증에서 해마 및 외측 뇌실의 부피와 뇌척수액배액검사

  • Kang, Kyunghun (Department of Neurology, School of Medicine, Kyungpook National University) ;
  • Han, Jaehwan (Department of Medical and Biological Engineering, Graduate School, Kyungpook National University) ;
  • Yoon, Uicheul (Department of Biomedical Engineering, Daegu Catholic University)
  • 강경훈 (경북대학교 의과대학 신경과학교실) ;
  • 한재환 (경북대학교 대학원 의용생체공학과) ;
  • 윤의철 (대구가톨릭대학교 의공학과)
  • Received : 2019.09.11
  • Accepted : 2019.10.11
  • Published : 2019.10.31
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Abstract

We investigated differences in ventricular and hippocampal volumes between CSF tap test (CSFTT) responders and non-responders in idiopathic normal-pressure hydrocephalus (INPH) patients and compared these parameters in INPH patients with that of age- and gender-matched healthy controls. We also evaluated relationships between ventricular and hippocampal volumes and clinical profiles in INPH patients. We enrolled 48 patients with INPH and 29 healthy controls. Ventricular and hippocampal volumes were measured on MRI, including 3-dimensional volumetric images. INPH patients, when compared to healthy controls, had significantly larger ventricular and smaller hippocampal volumes. No difference in ventricular and hippocampal volumes was found between CSFTT responders and non-responders in INPH patients. And hippocampal volumes showed significant negative correlations with Clinical Dementia Rating Scale scores, INPH grading scale cognitive scores, Timed Up and Go Test scores, and Unified Parkinson's Disease Rating Scale motor scores in INPH patients. Volumetric assessment of ventricular and hippocampal regions may have no predictive value in differentiating between CSFTT responders and non-responders in INPH patients. Our findings may help us understand the potential pathophysiology of unique symptoms associated with INPH.

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References

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