혜화의학회지 (Journal of Haehwa Medicine)

  • 제28권2호
  • /
  • Pages.1-11
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  • 2019
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  • 2586-3002(pISSN)
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  • 2586-3347(eISSN)
대전대학교 한의학연구소 (Research Institute of Korean Medicine)
권호 표지

복어독의 종양 관련 기존연구 논문에 대한 분석

Analysis for cancer-related studies using Puffer fish poison

  • 조용래 (대전대학교 동서생명과학연구원) ;
  • 이성배 (대전대학교 동서생명과학연구원) ;
  • 박세영 (대전대학교 한의학과) ;
  • 손창규 (대전대학교 동서생명과학연구원)
  • Cho, Yong Rae (Institute Traditional Medicine and Bioscience, Daejeon University) ;
  • Lee, Sung Bae (Institute Traditional Medicine and Bioscience, Daejeon University) ;
  • Park, Samuel Young (College of Korean medicine, Daejeon University) ;
  • Son, Chang Gue (Institute Traditional Medicine and Bioscience, Daejeon University)
  • 투고 : 2018.09.02
  • 심사 : 2019.04.12
  • 발행 : 2019.09.21
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⟨ 이전 논문 다음 논문 ⟩

초록

Objective: The aim of this study is to analyze the previously published research articles related to puffer fish toxin focusing on tumor. Method: Literatures were searched in PubMed database, published since 2000, using the keyword; Puffer fish, Fugu and tetrodotoxin (TTX) with cancer or tumor. Research papers were classified by year, country, study model, used material, kind of tumor and study subject. Finally, a total of 41 studies were analyzed in this study. Results: From 2000 to 2018, the most abundant papers were published in 2009 (6 studies) and almost half of the papers were studied in United Kingdom (20 studies). The 39 studies used TTX purified from puffer fish while 2 studies used crude extract of skin and gonad of puffer fish. The most used target cell line was prostate cancer (15 studies), and the next was breast cancer (14 studies). The study methods were classified into 4 clinical studies, 2 animal studies and 35 cell-based studies. Conclusions: Our results show that the overview of cancer-related studies using puffer fish poison. This information would be helpful for the puffer fish-derived drug researches in the future.

키워드

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