Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Risk Factors for Associated with Latent Tuberculosis Infection among Former Mine Workers

광업 이직근로자에서 잠복결핵감염 위험요인 분석

  • Hwang, Joo Hwan (Department of Pathogenic Laboratory Research, Institute of Occupation and Environment, the Korea Workers' Compensation and Welfare Service) ;
  • Shin, Jae Hoon (Department of Pathogenic Laboratory Research, Institute of Occupation and Environment, the Korea Workers' Compensation and Welfare Service) ;
  • Baek, JinEe (Department of Pathogenic Laboratory Research, Institute of Occupation and Environment, the Korea Workers' Compensation and Welfare Service) ;
  • Choi, Byung-Soon (Department of Research for Occupational Health, Institute of Occupation and Environment, the Korea Workers' Compensation and Welfare Service)
  • 황주환 (근로복지공단 직업환경연구원 발병기전연구부) ;
  • 신재훈 (근로복지공단 직업환경연구원 발병기전연구부) ;
  • 백진이 (근로복지공단 직업환경연구원 발병기전연구부) ;
  • 최병순 (근로복지공단 직업환경연구원 업무관련성평가부)
  • Received : 2019.07.24
  • Accepted : 2019.09.14
  • Published : 2019.09.30
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Abstract

Objectives: To identify the positive rate of and the risk factors associated with latent tuberculosis infection(LTBI) in mine workers, the objectives of the present study evaluated those among former mine workers. Methods: Between January 2015 and May 2017, former male mine workers who had been subjects for epidemiology research for work-related chronic obstructive pulmonary disease(COPD) and had received QuantiFERON-$TB^{(R)}$ Gold In-Tube(QFT-GIT) from the Institute of Occupation and Environment(IOE) under Korea Workers' Compensation and Welfare Service(KCOMWEL) were selected as the study subjects. To identify significant variables for increased risk of LTBI, logistic regression analysis was performed. Results: A total of 736 male former mine workers were selected as study subjects. The positive rate of LTBI among subjects was 69.2%(509/736). The current smoking[odds ratio(OR), 2.3; 95% confidence interval(CI), 1.1-4.9], COPD(OR, 1.4; 95% CI, 0.9-2.3), department loading(OR, 1.8; 95% CI, 0.9-3.4) and mining(OR, 1.5; 95% CI, 0.9-2.5), and working duration of over 20(OR, 1.6; 95% CI, 0.9-3.1) and over 30 years(OR, 2.2; 95% CI, 0.9-4.9) were associated with increased risk of LTBI. The interferon-gamma(IFN-${\gamma}$) level after stimulation with Mycobacterium tuberculosis(MTB)-specific antigens showed a significantly negative correlation with age(r=-0.126). Conclusions: The present study determined that the high positive rate of LTBI among mine workers was associated with not only the host factors but also the occupational exposure to mine dust.

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References

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