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Primary Chest Wall Sarcoma: Surgical Outcomes and Prognostic Factors

  • Park, Ilkun (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Sumin (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Hong Kwan (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Yong Soo (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Jhingook (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Zo, Jae Ill (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, Young Mog (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Cho, Jong Ho (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2018.12.26
  • Accepted : 2019.05.06
  • Published : 2019.10.05

Abstract

Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection. Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence-free survival (RFS). Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence. Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

Keywords

References

  1. Wouters MW, van Geel AN, Nieuwenhuis L, et al. Outcome after surgical resections of recurrent chest wall sarcomas. J Clin Oncol 2008;26:5113-8. https://doi.org/10.1200/JCO.2008.17.4631
  2. Walsh GL, Davis BM, Swisher SG, et al. A single-institutional, multidisciplinary approach to primary sarcomas involving the chest wall requiring full-thickness resections. J Thorac Cardiovasc Surg 2001;121:48-60. https://doi.org/10.1067/mtc.2001.111381
  3. Sabanathan S, Shah R, Mearns AJ. Surgical treatment of primary malignant chest wall tumours. Eur J Cardiothorac Surg 1997;11:1011-6. https://doi.org/10.1016/S1010-7940(97)00090-0
  4. Perry RR, Venzon D, Roth JA, Pass HI. Survival after surgical resection for high-grade chest wall sarcomas. Ann Thorac Surg 1990;49:363-8. https://doi.org/10.1016/0003-4975(90)90239-3
  5. Bagheri R, Haghi SZ, Kalantari MR, et al. Primary malignant chest wall tumors: analysis of 40 patients. J Cardiothorac Surg 2014;9:106. https://doi.org/10.1186/1749-8090-9-106
  6. King RM, Pairolero PC, Trastek VF, Piehler JM, Payne WS, Bernatz PE. Primary chest wall tumors: factors affecting survival. Ann Thorac Surg 1986;41:597-601. https://doi.org/10.1016/S0003-4975(10)63067-6
  7. Jonsson P, Gyllstedt E, Hambraeus G, Lillogil R, Rydholm A. Chest wall sarcoma: outcome in 22 patients after resection requiring thoracic cage reconstruction. Sarcoma 1998;2:143-7. https://doi.org/10.1080/13577149877894
  8. Athanassiadi K, Kalavrouziotis G, Rondogianni D, Loutsidis A, Hatzimichalis A, Bellenis I. Primary chest wall tumors: early and long-term results of surgical treatment. Eur J Cardiothorac Surg 2001;19:589-93. https://doi.org/10.1016/S1010-7940(01)00655-8
  9. Gross JL, Younes RN, Haddad FJ, Deheinzelin D, Pinto CA, Costa ML. Soft-tissue sarcomas of the chest wall: prognostic factors. Chest 2005;127:902-8. https://doi.org/10.1378/chest.127.3.902
  10. Sohn ST, Chon SH, Shinn SH, et al. Review of primary chest wall tumors. Korean J Thorac Cardiovasc Surg 1998;31:988-94.
  11. Mah JS, Choi BW, Yu HS. Primary tumors of the chest wall. Korean J Thorac Cardiovasc Surg 1974;7:61-5.
  12. Kim SM, Park SD, Jeong JH, Cho SR, Lee SH. Clinical experience of chest wall tumors: a review of twenty one cases. Korean J Thorac Cardiovasc Surg 1987;20:723-9.
  13. Lee MG, Oh TY, Chang WH. Clinical evaluation of chest wall tumors: review of 33 cases. Korean J Thorac Cardiovasc Surg 1995;28:778-83.
  14. Park KH, Kim KB, Sung SW, Kim JH. Surgical management of chest wall tumors. Korean J Thorac Cardiovasc Surg 1991;24:547-54.
  15. Paik HC, Kang JH, Choi SS, Chung KY. Clinical review of primary chest wall tumors. Korean J Thorac Cardiovasc Surg 2003;36:175-81.
  16. Kim CG, Kuh JH, Kim KS. Clinical study of primary chest wall tumors. Korean J Thorac Cardiovasc Surg 1998;31:155-61.